Please Wait
Applying Filters...
menu
    • menu
    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

    Virtual Booth

    Contact Supplier

    AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

    Virtual Booth

    Contact Supplier

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    benoxaprofen, ammonium salt

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 51234-28-7, Uniprofen, Oraflex, Coxigon, Opren, Inflamid
    Molecular Formula
    C16H12ClNO3
    Molecular Weight
    301.72  g/mol
    InChI Key
    MITFXPHMIHQXPI-UHFFFAOYSA-N
    FDA UNII
    17SZX404IM
    The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets from the market on August 5, 1982.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
    2.1.2 InChI
    InChI=1S/C16H12ClNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20)
    2.1.3 InChI Key
    MITFXPHMIHQXPI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)Cl)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    17SZX404IM
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Benoxaprofen, (+)-isomer

    2. Benoxaprofen, (+-)-isomer

    3. Benoxaprofen, (-)-isomer

    4. Benoxaprofen, Ammonium Salt

    5. Benoxaprofen, Monosodium Salt

    6. Lrcl 3794

    7. Oraflex

    2.3.2 Depositor-Supplied Synonyms

    1. 51234-28-7

    2. Uniprofen

    3. Oraflex

    4. Coxigon

    5. Opren

    6. Inflamid

    7. Dl-benoxaprofen

    8. Compound 90459

    9. Benoxaprofene

    10. Benoxaprofenum

    11. Benoxaprofeno

    12. 2-(2-(4-chlorophenyl)benzo[d]oxazol-5-yl)propanoic Acid

    13. Lilly 90459

    14. 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic Acid

    15. (+-)-benoxaprofen

    16. 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic Acid

    17. (1)-2-(4-chlorophenyl)benzoxazole-5-propionic Acid

    18. Nsc 299582

    19. Chebi:76114

    20. 5-benzoxazoleacetic Acid, 2-(4-chlorophenyl)-.alpha.-methyl-

    21. Nsc-299582

    22. 17szx404im

    23. 2-(p-chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic Acid

    24. Compd 90459

    25. Nsc299582

    26. 2-(2-(4-chlorophenyl)-1,3-benzoxazol-5-yl)propanoic Acid

    27. Benoxaprofene [inn-french]

    28. Benoxaprofenum [inn-latin]

    29. Benoxaprofeno [inn-spanish]

    30. 2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic Acid

    31. Benoxaprofen [usan:inn:ban]

    32. Lrcl 3794

    33. Oraflex (tn)

    34. 67434-14-4

    35. Einecs 257-069-7

    36. Benoxaprofen (usan/inn)

    37. Brn 1085080

    38. Unii-17szx404im

    39. (+-)-2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic Acid

    40. (rs)-benoxaprofen

    41. Einecs 266-692-3

    42. (+/-)-benoxaprofen

    43. Benoxaprofen [mi]

    44. Benoxaprofen [inn]

    45. Benoxaprofen [jan]

    46. Benoxaprofen [usan]

    47. Schembl24413

    48. Benoxaprofen [mart.]

    49. Compound-90459

    50. Benoxaprofen [who-dd]

    51. Chembl340978

    52. Dtxsid4022650

    53. (+-)-2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic Acid

    54. 5-benzoxazoleacetic Acid, 2-(4-chlorophenyl)-alpha-methyl, (+-)-

    55. Bdbm50088388

    56. Db04812

    57. Da-05331

    58. Hy-13568

    59. Cs-0007198

    60. Ft-0662523

    61. Ft-0662524

    62. C90147

    63. D03080

    64. A905882

    65. Q420082

    66. 2-(4-chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic Acid

    67. 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic Acid #

    68. (alphar)-2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic Acid

    69. (alphas)-2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic Acid

    70. (+/-)-2-(p-chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic Acid

    71. (.+/-.)-2-(p-chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic Acid

    72. 5-benzoxazoleacetic Acid, 2-(4-chlorophenyl)-.alpha.-methyl, (.+/-.)-

    73. 5-benzoxazoleacetic Acid, 2-(4-chlorophenyl)-.alpha.-methyl, (+/-)-

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 301.72 g/mol
    Molecular Formula C16H12ClNO3
    XLogP34.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass301.0505709 g/mol
    Monoisotopic Mass301.0505709 g/mol
    Topological Polar Surface Area63.3 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity384
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Lipoxygenase Inhibitors

    Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES. (See all compounds classified as Lipoxygenase Inhibitors.)

    Dermatologic Agents

    Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

    4.2 ATC Code

    M - Musculo-skeletal system

    M01 - Antiinflammatory and antirheumatic products

    M01A - Antiinflammatory and antirheumatic products, non-steroids

    M01AE - Propionic acid derivatives

    M01AE06 - Benoxaprofen