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2D Structure
Also known as: 2062-84-2, Anquil, Frenactil, Glianimon, Frenactyl, Concilium
Molecular Formula
C22H24FN3O2
Molecular Weight
381.4  g/mol
InChI Key
FEBOTPHFXYHVPL-UHFFFAOYSA-N
FDA UNII
97O6X78C53

A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567)
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-1H-benzimidazol-2-one
2.1.2 InChI
InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
2.1.3 InChI Key
FEBOTPHFXYHVPL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
2.2 Other Identifiers
2.2.1 UNII
97O6X78C53
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Anquil

2. Benperidol Neuraxpharm

3. Benperidol-neuraxpharm

4. Benperidolneuraxpharm

5. Frenactil

6. Glianimon

2.3.2 Depositor-Supplied Synonyms

1. 2062-84-2

2. Anquil

3. Frenactil

4. Glianimon

5. Frenactyl

6. Concilium

7. Mcn-jr-4584

8. Benzoperidol

9. Benzperidol

10. Glianimon Mite

11. R-4584

12. Benzeridol

13. R 4584

14. Cb 8089

15. 8089 C. B.

16. 2h-benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-

17. Nsc-170982

18. 2h-benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl)-1,3-dihydro-

19. 8089 C.b.

20. 1-(1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl)-2-benzimidazolinone

21. 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-1h-benzimidazol-2-one

22. Nsc170982

23. 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1h-benzo[d]imidazol-2(3h)-one

24. 97o6x78c53

25. Ncgc00016602-01

26. Cas-2062-84-2

27. 2-benzimidazolinone, 1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-

28. Dsstox_cid_25364

29. Dsstox_rid_80827

30. Dsstox_gsid_45364

31. 983-42-6

32. Anquil (van)

33. Benperidolo [dcit]

34. Benperidolo

35. Benperidolum

36. 1-{1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl}-2-benzimidazolinone

37. 2-benzimidazolinone, 1-(1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl)-

38. 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1h-benzimidazol-2-one

39. Benperidolum [inn-latin]

40. 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazol-2-one

41. 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one

42. 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-2h-benzimidazol-2-one

43. Benperidol [usan:inn:ban]

44. Mcn-jr 4584

45. Einecs 218-172-2

46. Nsc 170982

47. Brn 0900981

48. Benquil

49. 1-1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl-2-benzimidazolinone

50. 1-1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl-2-benzimidazolinone

51. Unii-97o6x78c53

52. 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one

53. Anquil Hydrochloride

54. Prestwick_778

55. Anquil (tn)

56. Frenactyl Hydrochloride

57. Benperidol [mi]

58. Benzperidol Hydrochloride

59. Benperidol [inn]

60. 4'-fluor-4-(4-(2-oxo-1-benzimidazolinyl)piperidino)butyrophenon

61. Benperidol (usan/inn)

62. Prestwick0_000484

63. Prestwick1_000484

64. Prestwick2_000484

65. Prestwick3_000484

66. Benperidol [usan]

67. Benperidol [mart.]

68. Benperidol [who-dd]

69. Bspbio_000347

70. 5-24-02-00375 (beilstein Handbook Reference)

71. Mls002153837

72. Schembl122650

73. Spbio_002268

74. Bpbio1_000383

75. Chembl297302

76. Gtpl9215

77. Dtxsid7045364

78. Bdbm81492

79. Chebi:93403

80. Benperidol [ep Monograph]

81. 2-benzimidazolinone, Hydrochloride

82. Hms1569b09

83. Hms2096b09

84. Hms2235h20

85. Hms3374b03

86. Hms3713b09

87. Zinc9232411

88. Tox21_110517

89. Bdbm50183266

90. Nsc_16363

91. Nsc169873

92. Pdsp1_000835

93. Pdsp2_000822

94. 3-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidyl]-1h-benzimidazol-2-one

95. Akos016339645

96. Tox21_110517_1

97. Ccg-220484

98. Db12867

99. Ks-1335

100. Nsc-169873

101. Ncgc00016602-02

102. Ncgc00016602-04

103. Ac-12200

104. Smr001233200

105. Cas_2062-84-2

106. Db-045313

107. Hy-121276

108. 2-benzimidazolinone, Hydrochloridemonohydrate

109. Cs-0081352

110. Ft-0634013

111. Wln: T56 Bmvnj D- Dt6ntj A3vr Df

112. D02627

113. 062b842

114. A814756

115. L000947

116. Q424412

117. Sr-01000841254

118. 2h-benzimidazol-2-one,3-dihydro-, Monohydrochloride

119. Sr-01000841254-2

120. Brd-k79425933-001-03-6

121. {1-1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl-2-benzimidazolinone}

122. 1-[1-[3-(p-fluorbenzoyl)propyl]-4-piperidyl]-2-benzimidazolinon

123. 2-benzimidazolinone, {1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-}

124. Gamma-[4-(2-oxo-1-benzimidazolinyl)-piperidino]-p-fluorobutyrophenone

125. 1-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidyl]-3h-benzoimidazol-2-one

126. 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1h-benzo[d] Imidazol-2(3h)-one

127. 2-benzimidazolinone, {1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-,} Hydrochloridemonohydrate

128. 2h-benzimidazol-2-one, {1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-}

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 381.4 g/mol
Molecular Formula C22H24FN3O2
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass381.18525518 g/mol
Monoisotopic Mass381.18525518 g/mol
Topological Polar Surface Area52.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity556
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


4.2 ATC Code

N05AD07

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N05 - Psycholeptics

N05A - Antipsychotics

N05AD - Butyrophenone derivatives

N05AD07 - Benperidol