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    Benzetimide hydrochloride

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 5633-14-7, Benzetimide hcl, Dioxatrine, Benzetimide hydrochloride [usan], Benzetimide (hydrochloride), 2-[1-benzyl-4-piperidyl]-2-phenylglutarimide
    Molecular Formula
    C23H27ClN2O2
    Molecular Weight
    398.9  g/mol
    InChI Key
    XSOOSXRNMDUWEM-UHFFFAOYSA-N
    FDA UNII
    V6ERX20PHB
    A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione;hydrochloride
    2.1.2 InChI
    InChI=1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H
    2.1.3 InChI Key
    XSOOSXRNMDUWEM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    V6ERX20PHB
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Benzetimide

    2. Dexbenzetimid

    3. Dexbenzetimide

    4. Dexetimide

    5. Dextro Benzetimide

    6. Dextro-benzetimide

    7. R 16470

    8. R-16470

    9. R16470

    10. Spasmentral

    11. Tremblex

    2.3.2 Depositor-Supplied Synonyms

    1. 5633-14-7

    2. Benzetimide Hcl

    3. Dioxatrine

    4. Benzetimide Hydrochloride [usan]

    5. Benzetimide (hydrochloride)

    6. 2-[1-benzyl-4-piperidyl]-2-phenylglutarimide

    7. Mcn-jr-4929-11

    8. V6erx20phb

    9. Janssen R 492

    10. Janssen-r-492

    11. Janssen R 4929

    12. 2-(1-benzyl-4-piperidyl)-2-phenylglutarimide Monohydrochloride

    13. Spasmentral

    14. 5633-14-7 (hcl)

    15. 3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione,hydrochloride

    16. (3,4'-bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, Monohydrochloride

    17. Benzetimide Hydrochloride (usan)

    18. Mcn-jr4929

    19. Mcn-jr 4929

    20. Einecs 227-072-8

    21. Unii-v6erx20phb

    22. Dioxatrine (tn)

    23. R 4929

    24. Dl-2-(1-benzyl-4-piperidyl)-2-phenylglutarimide Hydrochloride

    25. Dl-1-benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidine Hydrochloride

    26. Mls001201802

    27. Schembl635393

    28. Chembl545131

    29. Hy-b1547a

    30. Dtxsid101036320

    31. Bcp11991

    32. Bcp28424

    33. Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, Hydrochloride

    34. Benzetimide Hydrochloride [mi]

    35. 3-phenyl-1'-(phenylmethyl)(3,4'-bipiperidine)-2,6-dione Monohydrochloride

    36. Akos025402010

    37. Cs-5308

    38. Ac-28141

    39. Smr000718634

    40. Ft-0696859

    41. R4929

    42. D03087

    43. Q27291593

    44. 1'-benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione Hydrochloride

    45. Benzetimide Hcl; R4929 Hcl; R 4929 Hcl; R-4929 Hcl

    46. 3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione;hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 398.9 g/mol
    Molecular Formula C23H27ClN2O2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass398.1761058 g/mol
    Monoisotopic Mass398.1761058 g/mol
    Topological Polar Surface Area49.4 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity529
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)