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    Benzhexol hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Benzhexol hydrochloride, 52-49-3, Artane, Trihexyphenidyl hcl, Cyclodol, Parcopane
    Molecular Formula
    C20H32ClNO
    Molecular Weight
    337.9  g/mol
    InChI Key
    QDWJJTJNXAKQKD-UHFFFAOYSA-N
    FDA UNII
    AO61G82577
    One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
    2.1.3 InChI Key
    QDWJJTJNXAKQKD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    AO61G82577
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apo Trihex

    2. Apo-trihex

    3. Apotrihex

    4. Artane

    5. Benzhexol

    6. Cyclodol

    7. Hipokinon

    8. Parkinane

    9. Parkopan

    10. Trihexane

    11. Trihexidyl Hydrochloride

    12. Trihexyphenidyl

    13. Trihexyphenidyl Hydrochloride Elixir

    2.3.2 Depositor-Supplied Synonyms

    1. Benzhexol Hydrochloride

    2. 52-49-3

    3. Artane

    4. Trihexyphenidyl Hcl

    5. Cyclodol

    6. Parcopane

    7. Romparkin

    8. Tremin

    9. Benzhexol Hcl

    10. Artane Hydrochloride

    11. Triesifenidile

    12. Cyclodolum

    13. 58947-95-8

    14. Trihexyphenidyl (hydrochloride)

    15. Triphedinon

    16. Aparkane

    17. Sedrina

    18. Benzhexol, Hcl

    19. 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol Hydrochloride

    20. Dl-trihexyphenidyl Hydrochloride

    21. Nsc-757357

    22. Mls000069670

    23. Pacitane

    24. Trihexyphenidyl-d,l Hydrochloride

    25. Alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanol Hydrochloride

    26. Ao61g82577

    27. 52-49-3 (hcl)

    28. Ncgc00094393-02

    29. Triexifenidila

    30. Paralest

    31. Pargitan

    32. Parkopan

    33. Peragit

    34. Pipanol

    35. Smr000058515

    36. Tsiklodol

    37. 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol Hydrochloride

    38. 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride

    39. Dl-trihexyphenidylhydrochloride

    40. Benzhexol Chloride

    41. Dsstox_cid_25802

    42. Dsstox_rid_81140

    43. Dsstox_gsid_45802

    44. (+-)-alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanol Hydrochloride

    45. 1-piperidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride, (+-)-

    46. Cas-52-49-3

    47. Win 511

    48. Sr-01000000226

    49. Trihexyphenidyl Hydrochloride [jan]

    50. Einecs 200-142-5

    51. Unii-ao61g82577

    52. D,l-trihexyphenidyl, Hydrochloride

    53. Prestwick_133

    54. Artane (tn)

    55. Trihexyphenidyl Hydrochloride [usp:jan]

    56. 1-phenyl-1-cyclohexyl-3-piperidyl-1-propanol Hydrochloride

    57. 3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanol Hydrochloride

    58. 1-piperidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride

    59. Opera_id_1788

    60. Chembl1092

    61. Cyclodolum [who-ip]

    62. Schembl42410

    63. Mls001148658

    64. Mls002548898

    65. (+-)-benzhexol Hydrochloride

    66. Spectrum1500592

    67. Trihexyphenidyli Hydrochloridum

    68. Regid_for_cid_66007

    69. Chebi:9721

    70. Dtxsid8045802

    71. Niosh/tn2628000

    72. Hms1570m03

    73. Hms1921g17

    74. Pharmakon1600-01500592

    75. Bcp22935

    76. Hy-b1277

    77. Tox21_111274

    78. Tox21_501125

    79. Ccg-40279

    80. Mfcd00058212

    81. Nsc757357

    82. S4542

    83. Akos005267201

    84. Tox21_111274_1

    85. Ac-4520

    86. Bcp9000392

    87. Cs-4734

    88. Dl-trihexyphenidyl Hydrochloride, Solid

    89. Hs-0073

    90. Lp01125

    91. Nc00486

    92. Nsc 757357

    93. Benzhexol Hydrochloride [who-ip]

    94. Ncgc00016003-10

    95. Ncgc00094393-01

    96. Ncgc00094393-03

    97. Ncgc00094393-04

    98. Ncgc00094393-05

    99. Ncgc00261810-01

    100. Trihexyphenidyl Hydrochloride (jp17/usp)

    101. Trihexyphenidyl Hydrochloride [mi]

    102. Bcp0726000149

    103. Benzhexol Hcl;trihexyphenidyl Hydrochloride

    104. Eu-0101125

    105. Ft-0624385

    106. Ft-0652998

    107. T3303

    108. Tn26280000

    109. Trihexyphenidyl Hydrochloride [mart.]

    110. Trihexyphenidyl Hydrochloride [vandf]

    111. Trihexyphenidyl Hydrochloride [usp-rs]

    112. Trihexyphenidyl Hydrochloride [who-dd]

    113. Trihexyphenidyl Hydrochloride [who-ip]

    114. D00787

    115. D92689

    116. T 1516

    117. 052b493

    118. 058b212

    119. Trihexyphenidyl Hydrochloride [orange Book]

    120. Q-200685

    121. Sr-01000000226-2

    122. Sr-01000000226-7

    123. Trihexyphenidyl Hydrochloride [ep Monograph]

    124. Trihexyphenidyl Hydrochloride [usp Monograph]

    125. Q27274030

    126. Trihexyphenidyli Hydrochloridum [who-ip Latin]

    127. Z1551429739

    128. 1-cyclohexyl-1-phenyl-3-(1-piperidyl)-1-propanol Hydrochloride

    129. Trihexyphenidyl Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    130. Trihexyphenidyl Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    131. (+/-)-.alpha.-cyclohexyl-.alpha.-phenyl-1-piperidinepropanol Hydrochloride

    132. 1-piperidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, Hydrochloride, (+/-)-

    133. Trihexyphenidyl Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    134. Trihexyphenidyl Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 337.9 g/mol
    Molecular Formula C20H32ClNO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass337.2172423 g/mol
    Monoisotopic Mass337.2172423 g/mol
    Topological Polar Surface Area23.5 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity314
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameTrihexyphenidyl hydrochloride
    PubMed HealthTrihexyphenidyl Hydrochloride (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelTrihexyphenidyl HCl is a synthetic antispasmodic drug. It is designated chemically as -Cyclohexyl-phenyl-1-piperidinepropanol hydrochloride and its structural formula is as follows: C20H31NO HCl...
    Active IngredientTrihexyphenidyl hydrochloride
    Dosage FormElixir; Tablet
    RouteOral
    Strength2mg/5ml; 5mg; 2mg
    Market StatusPrescription
    CompanyVintage Pharms; Pharm Assoc; Natco Pharma; Watson Labs; Mikart

    2 of 2  
    Drug NameTrihexyphenidyl hydrochloride
    PubMed HealthTrihexyphenidyl Hydrochloride (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelTrihexyphenidyl HCl is a synthetic antispasmodic drug. It is designated chemically as -Cyclohexyl-phenyl-1-piperidinepropanol hydrochloride and its structural formula is as follows: C20H31NO HCl...
    Active IngredientTrihexyphenidyl hydrochloride
    Dosage FormElixir; Tablet
    RouteOral
    Strength2mg/5ml; 5mg; 2mg
    Market StatusPrescription
    CompanyVintage Pharms; Pharm Assoc; Natco Pharma; Watson Labs; Mikart

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)