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    Bepridil

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    ANALYTICAL

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 68099-86-5, Bepridil hcl, Cerm 1978, 1-isobutoxy-2-pyrrolidino-3-(n-benzylanilino)propane hydrochloride, 2tn7ff3w4m, Mls000028456
    Molecular Formula
    C24H35ClN2O
    Molecular Weight
    403.0  g/mol
    InChI Key
    JXBBWYGMTNAYNM-UHFFFAOYSA-N
    FDA UNII
    2TN7FF3W4M
    A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline;hydrochloride
    2.1.2 InChI
    InChI=1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H
    2.1.3 InChI Key
    JXBBWYGMTNAYNM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    2TN7FF3W4M
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1978 Cerm

    2. 1978-cerm

    3. 1978cerm

    4. Bedapin

    5. Bepadin

    6. Bepridil

    7. Bepridil Monohydrochloride

    8. Bepridil Monohydrochloride, Alpha Isomer

    9. Bepridil Monohydrochloride, Alpha-isomer

    10. Bepridil Monohydrochloride, Monohydrate

    11. Bepridil, (+)-isomer

    12. Bepridil, (+-)-isomer

    13. Bepridil, (-)-isomer

    14. Bepridil, Alpha Isomer

    15. Bepridil, Alpha-isomer

    16. Cerm 1978

    17. Cerm-1978

    18. Cerm1978

    19. Cordium

    20. Monohydrochloride, Alpha-isomer Bepridil

    21. Monohydrochloride, Bepridil

    22. Unicordium

    23. Vascor

    2.3.2 Depositor-Supplied Synonyms

    1. 68099-86-5

    2. Bepridil Hcl

    3. Cerm 1978

    4. 1-isobutoxy-2-pyrrolidino-3-(n-benzylanilino)propane Hydrochloride

    5. 2tn7ff3w4m

    6. Mls000028456

    7. Bepridil Hydrochloride Anhydrous

    8. Bepridil (hydrochloride Hydrate)

    9. Smr000058419

    10. N-benzyl-n-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline;hydrochloride

    11. 1-pyrrolidineethanamine,b-[(2-methylpropoxy)methyl]-n-phenyl-n-(phenylmethyl)-,monohydrochloride

    12. N-benzyl-n-(3-isobutoxy-2-(pyrrolidin-1-yl)propyl)aniline Hydrochloride

    13. Chebi:52712

    14. (+/-)-bepridil Hydrochloride Hydrate;org 5730 Hydrochloride Hydrate; Dl-bepridil Hydrochloride Hydrate

    15. 1978cerm

    16. Sr-01000075304

    17. Einecs 268-472-2

    18. Unii-2tn7ff3w4m

    19. Bepridilhcl

    20. Prestwick_697

    21. Opera_id_594

    22. 1-pyrrolidineethanamine, Beta-((2-methylpropoxy)methyl)-n-phenyl-n-(phenylmethyl)-, Monohydrochloride

    23. Mls001076139

    24. Mls001333221

    25. Mls001333222

    26. Mls002222245

    27. Bepridil Hydrochloride, Powder

    28. Spectrum1503106

    29. Regid_for_cid_50088

    30. Chembl1257078

    31. Dtxsid00964274

    32. Hms1569i17

    33. Hms1922e17

    34. Pharmakon1600-01503106

    35. Bcp34263

    36. Ex-a3081

    37. Tox21_500222

    38. Nsc758390

    39. Akos024457981

    40. N-benzyl-n-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline Hydrochloride

    41. Ccg-213110

    42. Lp00222

    43. N-benzyl-beta-((2-methylpropoxy)methyl)-n-phenylpyrrolidine-1-ethylamine Monohydrochloride

    44. Ncgc00093691-01

    45. Ncgc00093691-02

    46. Ncgc00093691-03

    47. Ncgc00093691-04

    48. Ncgc00093691-05

    49. Ncgc00260907-01

    50. Ac-36317

    51. Bs-17336

    52. Db-055107

    53. Hy-103315

    54. Cs-0027604

    55. Eu-0100222

    56. Ft-0641159

    57. B 5016

    58. D70189

    59. 099b865

    60. 764b402

    61. Org 5730 Hydrochloride Hydrate;bepridil Hcl H2o

    62. Sr-01000075304-1

    63. Sr-01000075304-7

    64. Q27123566

    65. 1-(2-(n-benzylanilino)-1-(isobutoxymethyl)ethyl)-pyrrolidine Monohydrochloride

    66. 1-pyrrolidineethanamine, .beta.-[(2-methylpropoxy)methyl]-n-phenyl-n-(phenylmethyl)-, Hydrochloride, Hydrate (1:1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 403.0 g/mol
    Molecular Formula C24H35ClN2O
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count10
    Exact Mass402.2437914 g/mol
    Monoisotopic Mass402.2437914 g/mol
    Topological Polar Surface Area15.7 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity382
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)