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    Bleomycin Sulphate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

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    $ API Ref.Price (USD/KG) : 478,114Xls

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    2D Structure
    Also known as: Bleomycin sulfate, 9041-93-4, Blexane, Bleomycin sulphate, Bleomycin, sulfate (salt), Bleomycin, sulfate
    Molecular Formula
    C55H85N17O25S4
    Molecular Weight
    1512.6  g/mol
    InChI Key
    WUIABRMSWOKTOF-OCBSMOPSSA-N
    A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
    2.1.2 InChI
    InChI=1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1
    2.1.3 InChI Key
    WUIABRMSWOKTOF-OCBSMOPSSA-N
    2.1.4 Canonical SMILES
    CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
    2.1.5 Isomeric SMILES
    CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Bellon, Blomycine

    2. Blomycine Bellon

    3. Blanoxan

    4. Bleo Cell

    5. Bleo-cell

    6. Bleocell

    7. Bleolem

    8. Bleomicina

    9. Bleomycin

    10. Bleomycin A(2)

    11. Bleomycin A2

    12. Bleomycin B(2)

    13. Bleomycin B2

    14. Bleomycin Sulfate

    15. Bleomycins

    16. Bleomycinum Mack

    17. Mack, Bleomycinum

    18. Sulfate, Bleomycin

    2.2.2 Depositor-Supplied Synonyms

    1. Bleomycin Sulfate

    2. 9041-93-4

    3. Blexane

    4. Bleomycin Sulphate

    5. Bleomycin, Sulfate (salt)

    6. Bleomycin, Sulfate

    7. Bleomycin Sulfate [bleomycins]

    8. Ccris 2470

    9. Bleomycin Sulfate (salt)

    10. Einecs 232-925-2

    11. Unii-7dp3ntv15t

    12. Bleomycin Sulfate [usan:usp:jan]

    13. Bleomycin Sulfate Salt

    14. 7dp3ntv15t

    15. Schembl1648595

    16. Mfcd00070310

    17. Akos015896273

    18. Akos022190415

    19. Sr-01000941586

    20. Sr-01000941586-2

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 1512.6 g/mol
    Molecular Formula C55H85N17O25S4
    Hydrogen Bond Donor Count21
    Hydrogen Bond Acceptor Count35
    Rotatable Bond Count36
    Exact Mass1511.4785360 g/mol
    Monoisotopic Mass1511.4785360 g/mol
    Topological Polar Surface Area770 Ų
    Heavy Atom Count101
    Formal Charge0
    Complexity2660
    Isotope Atom Count0
    Defined Atom Stereocenter Count10
    Undefined Atom Stereocenter Count9
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameBleomycin sulfate
    Drug LabelBleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus. It is freely soluble in water.It is available as a lyophilized powder for intramuscular, intravenous or subcutaneous i...
    Active IngredientBleomycin sulfate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 15 units base/vial; eq 30 units base/vial
    Market StatusPrescription
    CompanyFresenius Kabi Usa; Hospira; Teva Pharms Usa; Eurohlth Intl

    2 of 2  
    Drug NameBleomycin sulfate
    Drug LabelBleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus. It is freely soluble in water.It is available as a lyophilized powder for intramuscular, intravenous or subcutaneous i...
    Active IngredientBleomycin sulfate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 15 units base/vial; eq 30 units base/vial
    Market StatusPrescription
    CompanyFresenius Kabi Usa; Hospira; Teva Pharms Usa; Eurohlth Intl

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antibiotics, Antineoplastic

    Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cytoprotective Agent [EPC]