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    Brompheniramine Maleate

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

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    PharmaCompass
    $ API Ref.Price (USD/KG) : 200Xls

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    2D Structure
    Also known as: 980-71-2, Brompheniramine hydrogen maleate, Dimetane, Rolabromophen, Dimotane, Parabromdylamine maleate
    Molecular Formula
    C20H23BrN2O4
    Molecular Weight
    435.3  g/mol
    InChI Key
    SRGKFVAASLQVBO-BTJKTKAUSA-N
    FDA UNII
    IXA7C9ZN03
    Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
    2.1.2 InChI
    InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    SRGKFVAASLQVBO-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    IXA7C9ZN03
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Brompheniramine

    2. Brompheniramine Maleate (1:1)

    3. Chlorphed

    4. Dimetane

    5. Dimetane Ten

    6. Dimetane-ten

    7. Dimetapp Allergy

    8. Maleate, Brompheniramine

    9. Oraminic 2

    10. Oraminic-2

    11. P Bromdylamine

    12. P-bromdylamine

    13. Para Bromdylamine

    14. Para-bromdylamine

    2.3.2 Depositor-Supplied Synonyms

    1. 980-71-2

    2. Brompheniramine Hydrogen Maleate

    3. Dimetane

    4. Rolabromophen

    5. Dimotane

    6. Parabromdylamine Maleate

    7. Veltane

    8. Dimetane-ten

    9. Brompheniramine (maleate)

    10. Lodrane

    11. Brompheniramine Maleate [usp]

    12. (+/-)-brompheniramine Maleate

    13. Dimetapp Allergy

    14. Nsc-758652

    15. Ixa7c9zn03

    16. Mls000028423

    17. Chebi:3184

    18. (+/-)-brompheniramine Maleate Salt

    19. Drauxin

    20. Gammistin

    21. Nagemid

    22. Smr000058417

    23. Spentane

    24. Allent

    25. Ebalin

    26. 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate

    27. Brompheniramine Maleate (usp)

    28. Drixoral Syrup

    29. Mfcd00057367

    30. Dimetane Extentabs

    31. Bromopheniramine Maleate

    32. Sr-01000003057

    33. Einecs 213-562-9

    34. Unii-ixa7c9zn03

    35. Brompheniraminemaleate

    36. 2-[p-bromo-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine Maleate

    37. Dimetane (tn)

    38. Prestwick_913

    39. 3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

    40. Brompheniramine Fumarate

    41. 3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine;(z)-but-2-enedioic Acid

    42. Opera_id_399

    43. 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

    44. (y)-brompheniramine Maleate

    45. (?)-brompheniramine Maleate

    46. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (+-)-, (z)-2-butenedioate (1:1)

    47. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (z)-butenedioate (1:1)

    48. Schembl41913

    49. Mls001148196

    50. Spectrum1503985

    51. Bioompheniramine Hydrogen Maleate

    52. Chembl1200961

    53. Dtxsid2052657

    54. (a+/-)-brompheniramine Maleate

    55. Bcpp000315

    56. Hms1569o12

    57. Hms1922o16

    58. Hms2093o07

    59. Hms2096o12

    60. Hms2230i21

    61. Hms2234d14

    62. Hms3260j03

    63. Hms3713o12

    64. Hms3884j10

    65. Pharmakon1600-01503985

    66. Hy-b0480

    67. Tox21_500201

    68. Ccg-39068

    69. Nsc758652

    70. S2585

    71. (+-)-2-p-bromo-alpha-2-(dimethylamino)ethylbenzylpyridine Maleate (1:1)

    72. Akos015855858

    73. Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

    74. Ac-1311

    75. Bcp9000453

    76. Brompheniramine Maleate [mart.]

    77. Brompheniramine Maleate [vandf]

    78. Lp00201

    79. Nsc 758652

    80. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (+-)-, (z)-butenedioate (1:1)

    81. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

    82. Brompheniramine Maleate [usp-rs]

    83. Brompheniramine Maleate [who-dd]

    84. Ncgc00093676-01

    85. Ncgc00093676-02

    86. Ncgc00093676-03

    87. Ncgc00093676-04

    88. Ncgc00093676-05

    89. Ncgc00260886-01

    90. As-14101

    91. Smr000653459

    92. Bcp0726000240

    93. Brompheniramine Maleate [ep Impurity]

    94. Brompheniramine Maleate [orange Book]

    95. Eu-0100201

    96. Sw197031-3

    97. Brompheniramine Maleate [ep Monograph]

    98. B 2390

    99. Brompheniramine Maleate [usp Monograph]

    100. D00663

    101. ( Inverted Question Mark)-brompheniramine Maleate

    102. Biphetap Component Brompheniramine Maleate

    103. Dimetapp Component Brompheniramine Maleate

    104. Bromanate Component Brompheniramine Maleate

    105. Bromatapp Component Brompheniramine Maleate

    106. Bromfed-dm Component Brompheniramine Maleate

    107. Brompheniramine Maleate Component Of Biphetap

    108. Brompheniramine Maleate Component Of Dimetapp

    109. Dimetane-dc Component Brompheniramine Maleate

    110. Dimetane-dx Component Brompheniramine Maleate

    111. Sr-01000003057-2

    112. Sr-01000003057-4

    113. Sr-01000003057-5

    114. Sr-01000003057-8

    115. W-100095

    116. Bromanate Dc Component Brompheniramine Maleate

    117. Bromanate Dm Component Brompheniramine Maleate

    118. Brompheniramine Maleate Component Of Bromanate

    119. Brompheniramine Maleate Component Of Bromatapp

    120. Brompheniramine Maleate Component Of Bromfed-dm

    121. Myphetane Dc Component Brompheniramine Maleate

    122. Q27105975

    123. Brompheniramine Maleate Component Of Bromanate Dc

    124. Brompheniramine Maleate Component Of Bromanate Dm

    125. Brompheniramine Maleate Component Of Dimetane-dc

    126. Brompheniramine Maleate Component Of Dimetane-dx

    127. Brompheniramine Maleate Component Of Myphetane Dc

    128. (+/-)-brompheniramine Maleate 100 Microg/ml In Methanol

    129. 2- P-bromo-a-2-(dimethylamino)ethylbenzylpyridine Maleate

    130. 2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine Maleate

    131. Brompheniramine Maleate 1.0 Mg/ml In Methanol (as Free Base)

    132. 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane Maleate

    133. 3-(p-bromophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine Maleate

    134. Gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamine Maleate

    135. (+/-)-brompheniramine Maleate 100 Microg/ml In Acetonitrile:methanol

    136. 3-(4-bromophenyl)-n,n-dimethyl-3-(2-pyridinyl)-1-propanamine Maleate

    137. Brompheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

    138. (+/-)-2-p-bromo-.alpha.-2-(dimethylamino)ethylbenzylpyridine Maleate (1:1)

    139. 3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine (2z)-but-2-enedioate

    140. Brompheniramine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material

    141. 2-pyridinepropanamine, .gamma.-(4-bromophenyl)-n,n-dimethyl-, (+/-)-, (z)-butenedioate (1:1)

    142. 2664-17-7

    143. Brompheniramine Maleate Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 435.3 g/mol
    Molecular Formula C20H23BrN2O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass434.08412 g/mol
    Monoisotopic Mass434.08412 g/mol
    Topological Polar Surface Area90.7 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity368
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameBrompheniramine maleate
    Active IngredientBrompheniramine maleate
    Dosage FormTablet
    Routeoral
    Strength4mg
    Market StatusPrescription
    CompanyPhoenix Labs Ny; Nylos

    2 of 4  
    Drug NameVeltane
    Active IngredientBrompheniramine maleate
    Dosage FormTablet
    Routeoral
    Strength4mg
    Market StatusPrescription
    CompanyLannett

    3 of 4  
    Drug NameBrompheniramine maleate
    Active IngredientBrompheniramine maleate
    Dosage FormTablet
    Routeoral
    Strength4mg
    Market StatusPrescription
    CompanyPhoenix Labs Ny; Nylos

    4 of 4  
    Drug NameVeltane
    Active IngredientBrompheniramine maleate
    Dosage FormTablet
    Routeoral
    Strength4mg
    Market StatusPrescription
    CompanyLannett

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)