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    buclizine

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 129-74-8, Buclizine hydrochloride, Longifene, Buclizine hcl, Buclina, Softran
    Molecular Formula
    C28H35Cl3N2
    Molecular Weight
    505.9  g/mol
    InChI Key
    SDBHDSZKNVDKNU-UHFFFAOYSA-N
    FDA UNII
    V4OCE982YU
    Buclizine Hydrochloride is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine;dihydrochloride
    2.1.2 InChI
    InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H
    2.1.3 InChI Key
    SDBHDSZKNVDKNU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)(C)C1=CC=C(C=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    V4OCE982YU
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)piperazine

    2. Aphilan

    3. Bucladin-s

    4. Buclizine

    5. Buclizine Hydrochloride

    6. Softran

    2.3.2 Depositor-Supplied Synonyms

    1. 129-74-8

    2. Buclizine Hydrochloride

    3. Longifene

    4. Buclizine Hcl

    5. Buclina

    6. Softran

    7. 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine Dihydrochloride

    8. Buclizine, Dihydrochloride

    9. Bucladin-s

    10. Aphilan

    11. Buclodin

    12. Ucb 4445

    13. Aphilan R

    14. Bucladin

    15. Buclizine Hydrochloride [usan]

    16. Vibazine Hydrochloride

    17. Ucb-4445

    18. Vibazine

    19. Histabutyzine Hydrochloride

    20. Histabutyzine Dihydrochloride

    21. Buclizine (dihydrochloride)

    22. Eop5593fph

    23. V4oce982yu

    24. 58fqd093nu

    25. Buclizine Hydrochloride, (+)-

    26. Buclizine Hydrochloride, (-)-

    27. Chebi:61193

    28. 1-(p-chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediamine Dihydrochloride

    29. 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine Dihydrochloride

    30. 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine;dihydrochloride

    31. Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, Dihydrochloride

    32. Postafeno

    33. A 7668

    34. Bucladin S

    35. Nsc-25141

    36. 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)-(phenyl)methyl)piperazine Dihydrochloride

    37. Buclizine Hydrochloride (usan)

    38. 1-(p-tert-butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine Dihydrochloride

    39. Buclizine 2hcl

    40. 163837-35-2

    41. 163837-36-3

    42. Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, Dihydrochloride, (+)-

    43. Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, Dihydrochloride, (-)-

    44. Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, Hydrochloride (1:2)

    45. Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, Dihydrochloride

    46. Einecs 204-962-4

    47. Nsc 25141

    48. Unii-58fqd093nu

    49. Vibazine (tn)

    50. 1-(p-tert-butylbenzyl)-4-(p-chloro-.alpha.-phenylbenzyl)piperazine Dihydrochloride

    51. 1-p-chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine Dihydrochloride

    52. Unii-eop5593fph

    53. Unii-v4oce982yu

    54. Dsstox_cid_25091

    55. Dsstox_rid_80665

    56. Dsstox_gsid_45091

    57. Schembl123751

    58. Chembl2360580

    59. Dtxsid5045091

    60. Perlapine, >=98% (hplc)

    61. Hy-a0128a

    62. Bcp22428

    63. Tox21_110023

    64. Mfcd00242700

    65. S4140

    66. Buclizine Dihydrochloride [mi]

    67. 5-isopropyl-2-methoxyphenylboronicacid

    68. Akos016004771

    69. Bcp9000459

    70. Buclizine Hydrochloride [mart.]

    71. Buclizine Hydrochloride [vandf]

    72. Ks-1250

    73. Buclizine Hydrochloride [who-dd]

    74. Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-, Dihydrochloride

    75. Ncgc00013315-01

    76. Ac-32891

    77. Cas-129-74-8

    78. Bcp0726000050

    79. Buclizine Dihydrochloride, >=98% (hplc)

    80. Buclizine Hydrochloride [orange Book]

    81. Cs-0019690

    82. Ft-0663892

    83. D02089

    84. 129b748

    85. J-005711

    86. Q27130875

    87. (rs)-1-(4-t-butylbenzyl)-4-(4-chlorobenzhydryl) Piperazine Dihydrochloride

    88. 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazinedihydrochloride

    89. 1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine Dihydrochloride

    90. 1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazinediium Dichloride

    91. 7139-55-1

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 505.9 g/mol
    Molecular Formula C28H35Cl3N2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count6
    Exact Mass504.186582 g/mol
    Monoisotopic Mass504.186582 g/mol
    Topological Polar Surface Area6.5 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity514
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine Antagonists

    Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)