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    Buphenine hydrochloride

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 849-55-8, Buphenine hydrochloride, Nylidrin (hydrochloride), Nylidrin hcl, Arlibide, Arlidin
    Molecular Formula
    C19H26ClNO2
    Molecular Weight
    335.9  g/mol
    InChI Key
    CLJHABUMMDMAFA-UHFFFAOYSA-N
    FDA UNII
    EC69E3PW7E
    A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H25NO2.ClH/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17;/h3-7,10-15,19-22H,8-9H2,1-2H3;1H
    2.1.3 InChI Key
    CLJHABUMMDMAFA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(CCC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    EC69E3PW7E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Arlidin

    2. Bufenine

    3. Buphenin

    4. Buphenine

    5. Dilatol

    6. Hydrochloride, Nylidrin

    7. Nylidrin

    2.3.2 Depositor-Supplied Synonyms

    1. 849-55-8

    2. Buphenine Hydrochloride

    3. Nylidrin (hydrochloride)

    4. Nylidrin Hcl

    5. Arlibide

    6. Arlidin

    7. Buphedrin

    8. Dilatol

    9. Vasiten

    10. Buphenin Hydrochloride

    11. Nsc-142004

    12. Mls000069387

    13. Dilatyl

    14. Suprifen Psb Hydrochloride

    15. 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol;hydrochloride

    16. Smr000058488

    17. Nylidrin Hydrochloride (jan)

    18. Ec69e3pw7e

    19. Nylidrin Hydrochloride [jan]

    20. Sr-01000002981

    21. Buphenine Hcl

    22. P-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl Alcohol Hydrochloride

    23. P-hydroxy-.alpha.-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzyl Alcohol Hydrochloride

    24. Arlidin (tn)

    25. Nylidrine Hydrochloride

    26. Opera_id_1722

    27. Mls001076116

    28. Schembl364078

    29. Spectrum1500445

    30. Chembl1204337

    31. Chebi:31925

    32. Dtxsid20957360

    33. Hms1920d06

    34. Pharmakon1600-01500445

    35. Nylidrin Hydrochloride [mi]

    36. Amy23363

    37. Hy-b1404

    38. Tox21_500911

    39. Ccg-40183

    40. Mfcd00035085

    41. Nsc142004

    42. Nsc757252

    43. S5267

    44. Nylidrin Hydrochloride [vandf]

    45. Wln: Qr Dyqy1&my1&2r &gh

    46. Akos030242878

    47. Buphenine Hydrochloride [mart.]

    48. Cs-4980

    49. Lp00911

    50. Nsc-757252

    51. Buphenine Hydrochloride [who-dd]

    52. Ncgc00094222-01

    53. Ncgc00094222-02

    54. Ncgc00094222-03

    55. Ncgc00094222-04

    56. Ncgc00261596-01

    57. As-19644

    58. Eu-0100911

    59. Ft-0757340

    60. N-153

    61. D01543

    62. A923155

    63. Q9668243

    64. Sr-01000002981-2

    65. 4-(1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl)phenol Hydrochloride

    66. 1-p-hydroxyphenyl-2-[(1'-methyl-3'-phenylpropyl)amino]-1-propanol Hydrochloride

    67. 4-{1-hydroxy-2-[(4-phenyl-2-butanyl)amino]propyl}phenol Hydrochloride (1:1)

    68. 900-01-6

    69. Benzenemethanol, 4-hydroxy-.alpha.-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-, Hydrochloride

    2.4 Create Date
    2006-03-07
    3 Chemical and Physical Properties
    Molecular Weight 335.9 g/mol
    Molecular Formula C19H26ClNO2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count7
    Exact Mass335.1652068 g/mol
    Monoisotopic Mass335.1652068 g/mol
    Topological Polar Surface Area52.5 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity296
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count3
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Adrenergic beta-Agonists

    Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)

    Tocolytic Agents

    Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)