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    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 57-37-4, Neuroleptone, Tranquilline, Amitakon, Nutinal, Parasan
    Molecular Formula
    C20H26ClNO3
    Molecular Weight
    363.9  g/mol
    InChI Key
    ZCEHOOLYWQBGQO-UHFFFAOYSA-N
    FDA UNII
    26R628272Q
    A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate;hydrochloride
    2.1.2 InChI
    InChI=1S/C20H25NO3.ClH/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,3-4,15-16H2,1-2H3;1H
    2.1.3 InChI Key
    ZCEHOOLYWQBGQO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    26R628272Q
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amizil

    2. Amizyl

    3. Benactyzine

    4. Lucidil

    2.3.2 Depositor-Supplied Synonyms

    1. 57-37-4

    2. Neuroleptone

    3. Tranquilline

    4. Amitakon

    5. Nutinal

    6. Parasan

    7. Suavitil

    8. Cedad

    9. Benaktin

    10. Destendo

    11. Ibiotyzil

    12. Leucidil

    13. Nervacton

    14. Nervatil

    15. Neuraktil

    16. Neurobenzil

    17. Valladan

    18. Valladon

    19. Aktozin

    20. Amisil

    21. Amisyl

    22. Amizil

    23. Amysyl

    24. Amyzyl

    25. Arkadin

    26. Cafron

    27. Cevanol

    28. Katron

    29. Lucidil

    30. Parazan

    31. Parpon

    32. Phobex

    33. Procalm

    34. Prokalm

    35. Stoikon

    36. Fobex

    37. 2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate Hydrochloride

    38. Amizil Hydrochloride

    39. Amizyl Hydrochloride

    40. Benactyzine Chloride

    41. Benactyzine Hcl

    42. Benactizine Hydrochloride

    43. Benactyzin

    44. Win 5606

    45. 2-diethylaminoethyl Benzilate Hydrochloride

    46. Ay 5406-1

    47. 2-diethylaminoethyl Diphenylglycolate Hydrochloride

    48. 57-37-4 (hcl)

    49. Mls000069801

    50. Benzilate Du Diethylamino-ethanol Chlorhydrate

    51. Diphenylglycollic Acid 2-(diethylamino)ethyl Ester Hydrochloride

    52. Nsc-16339

    53. 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid

    54. Morcain

    55. Smr000059142

    56. 26r628272q

    57. .beta.-diethylaminoethyl Benzilate Hydrochloride

    58. Benactyzin [czech]

    59. 2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate;hydrochloride

    60. Einecs 200-324-4

    61. Nsc 16339

    62. Ea 2092

    63. Amioyl

    64. Ai3-26379

    65. Beta-diethylaminoethyl Benzilate Hydrochloride

    66. Unii-26r628272q

    67. Ethanol, 2-(diethylamino)-, Benzilate Hydrochloride

    68. Benzilate Du Diethylamino-ethanol Chlorhydrate [french]

    69. Ay-5406

    70. Benzilic Acid Beta-diethylaminoethyl Ester Hydrochloride

    71. Alpha-hydroxy-alpha-phenylbenzeneacetic Acid 2-(diethylamino)ethyl Ester

    72. Opera_id_144

    73. 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech]

    74. 2-diethylaminoethylester Kyseliny Benzilove Hydrochlorid [czech]

    75. Benzeneacetic Acid, Alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl Ester, Hydrochloride

    76. Mls001148661

    77. Mls001424153

    78. Schembl4419579

    79. Ethanol, Benzilate Hydrochloride

    80. 2-diethylaminoethylester Kyseliny Benzilove Hydrochlorid

    81. Chembl1584883

    82. Dtxsid8052774

    83. Hy-b1542a

    84. Benzilic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

    85. 2-diethylaminoethyl 2-hydroxy-2,2-diphenylacetate Hydrochloride

    86. Nsc16339

    87. Mfcd00012624

    88. S3701

    89. Wln: Qxr&r&vo2n2&2 &gh

    90. Benactyzine Hydrochloride [mi]

    91. Akos015901413

    92. Ccg-101069

    93. Cs-8073

    94. Nc00319

    95. Benactyzine Hydrochloride [mart.]

    96. Benactyzine Hydrochloride [vandf]

    97. Ac-32563

    98. Benactyzine Hydrochloride [who-dd]

    99. Benzeneacetic Acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl Ester, Hydrochloride

    100. Ds-11395

    101. Benactyzine Hydrochloride, >=98% (hplc)

    102. Ay-5406-1

    103. Db-053044

    104. 2-(diethylamino)ethyl Benzilate Hydrochloride

    105. B0053

    106. Ft-0612170

    107. D88595

    108. Q27254124

    109. Benzilic Acid 2-(diethylamino)ethyl Ester Hydrochloride

    110. Benzilic Acid, 2-(diethylamino)ethyl Ester Hydrochloride

    111. Benzilic Acid .beta.-diethylaminoethyl Ester Hydrochloride

    112. Benzeneacetic Acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

    113. Benzeneacetic Acid, Alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 363.9 g/mol
    Molecular Formula C20H26ClNO3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count9
    Exact Mass363.1601214 g/mol
    Monoisotopic Mass363.1601214 g/mol
    Topological Polar Surface Area49.8 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity351
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidepressive Agents

    Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)