1. 25 Hydroxycholecalciferol
2. 25 Hydroxycholecalciferol Monohydrate
3. 25 Hydroxyvitamin D 3
4. 25 Hydroxyvitamin D3
5. 25-hydroxycholecalciferol
6. 25-hydroxycholecalciferol Monohydrate
7. 25-hydroxyvitamin D 3
8. 25-hydroxyvitamin D3
9. Anhydrous, Calcifediol
10. Calcidiol
11. Calcifediol Anhydrous
12. Calcifediol, (3 Alpha,5z,7e)-isomer
13. Calcifediol, (3 Beta,5e,7e)-isomer
14. Calderol
15. Dedrogyl
16. Hidroferol
17. Monohydrate, 25-hydroxycholecalciferol
1. Calcidiol
2. 25-hydroxyvitamin D3
3. 19356-17-3
4. 25-hydroxycholecalciferol
5. Calcifediol Anhydrous
6. Hidroferol
7. 25-hydroxyvitamin D
8. Calderol
9. Didrogyl
10. Calcifediolum
11. Rayaldee
12. Ro 8-8892
13. 5,6-cis-25-hydroxyvitamin D3
14. Calcifediol [inn]
15. Cholecalciferol, 25-hydroxy-
16. Chebi:17933
17. (3s,5z,7e)-9,10-secocholesta-5,7,10-triene-3,25-diol
18. T0wxw8f54e
19. 3-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexanol
20. Ncgc00161326-04
21. Calcifidiol
22. Delakmin
23. 25-hydroxy Vitamin D3
24. (3beta,5z,7e)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol
25. (5z,7e)-(3s)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol
26. U-32070e
27. U 32070 E
28. 25-hydroxyvitamin D3 / 25-hydroxycholecalciferol / Calcidiol
29. 25-hydroxycholescalciferol
30. Calcifediolum [inn-latin]
31. Rovimix Hy-d
32. (1s,3z)-3-{2-[(1r,3as,4e,7ar)-1-[(2r)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1h-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
33. (3b,5z,7e)- 9,10-secocholesta-5,7,10(19)-triene-3,25-diol
34. Vitamin D, 25-hydroxy-
35. Hy-d
36. (1s,3z)-3-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
37. 36149-00-5
38. 25-(oh)vitamin D3
39. 5,6-trans-25-hydroxycholescalciferol
40. Unii-t0wxw8f54e
41. Ryaldee
42. Bml2-e02
43. (5z,7e)-(3s)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol
44. 25(oh)d3
45. Einecs 242-990-9
46. Mfcd00867077
47. U 32070e
48. Calcifediol [mi]
49. (5z,7e)-9,10-seco-5,7,10(19)-cholestatrien-3beta,25-diol
50. 5,6-trans-9,10-seco-5,7,10(19)-cholestatrien-3beta,25-diol
51. Spectrum5_001931
52. Dsstox_cid_2721
53. 25-hydroxy-cholecalciferol
54. Calcifediol,anhydrous
55. Schembl3296
56. Chembl1040
57. Dsstox_rid_76699
58. Dsstox_gsid_22721
59. Bspbio_001411
60. Calcifediol, Anhydrous
61. (3s,5z,7e)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol
62. Gtpl6921
63. Dtxsid0022721
64. Chebi:94743
65. Amy2863
66. Bcpp000306
67. Dm100
68. Hms1361g13
69. Hms1791g13
70. Hms1989g13
71. Hms2089l21
72. Hms3402g13
73. 64719-49-9
74. Act06833
75. Zinc4474414
76. Tox21_111987
77. (3s,5z,7e)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol
78. 9,10-secocholesta-5,7,10(19)-triene-3,25-diol, (3beta,5z,7e)-
79. Bdbm50521013
80. Calcifediol,anhydrous [vandf]
81. Lmst03020246
82. S1469
83. Akos015965097
84. Bcp9000472
85. Ccg-268657
86. Cs-0800
87. Db00146
88. Idi1_033881
89. Ncgc00161326-01
90. Ac-31367
91. Hy-32351
92. Cas-19356-17-3
93. 25-hydroxycholecalciferol, >=98% (hplc)
94. C01561
95. Ab01275461-01
96. Ab01275461_02
97. 356c173
98. A923587
99. Q139307
100. Sr-05000001468
101. Sr-05000001468-1
102. W-201718
103. 25-hydroxyvitamin D3 Monohydrate, >=99.0% (hplc)
104. 9,10-secocholesta-5,7,10(19)-triene-3b,25-diol
105. Brd-k77175907-001-01-5
106. B91135ec-8937-4d8b-a533-ccd82f33c1b0
107. Calcifediol, European Pharmacopoeia (ep) Reference Standard
108. (5e,7e)-9,10-secocholesta-5,7,10(19)-triene-3beta,25-diol
109. 25-hydroxyvitamin D3 Solution, 100 Mug/ml In Ethanol, 98% (cp)
110. 25-hydroxyvitamin D3 Solution, 5 Mug/ml In Ethanol, 98% (cp)
111. 25-hydroxyvitamin D3 Solution, 50 Mug/ml In Ethanol, 98% (cp)
112. Calcifediol, United States Pharmacopeia (usp) Reference Standard
113. (3s,5z,14beta,17alpha)-9,10-secocholesta-5,7,10-triene-3,25-diol
114. (5z,7e)-9,10-secocholesta-5,7,10(19)-triene-3b,25-diol Monohydrate
115. 9,10-secocholesta-5,7,10(19)-triene-1,25-diol, (3.beta,.5z,7e)-
116. (?r,1r,3as,4e,7ar)-4-[(2z)-2-[(5s)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-?,?,?,7a-tetramethyl-1h-indene-1-pentanol
117. (1s,3z)-3-[(2e)-2-[(1r,3as,7ar)-1-[(1r)-5-hydroxy-1,5-dimethyl-hexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol
118. (s,z)-3-((e)-2-((1r,3as,7ar)-1-((r)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1h-inden-4(2h)-ylidene)ethylidene)-4-methylenecyclohexanol
119. 1h-indene-1-pentanol, Octahydro-4-[(2z)-2-[(5s)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-.alpha.,.alpha.,.epsilon.,7a-tetramethyl-, (.epsilon.r,1r,3as,4e,7ar)-
120. 25-hydroxyvitamin D3 Solution, 100 Mug/ml In Ethanol, Ampule Of 1 Ml, Certified Reference Material
121. 25-hydroxyvitamin D3 Solution, 5 Mug/ml In Ethanol, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 400.6 g/mol |
|---|---|
| Molecular Formula | C27H44O2 |
| XLogP3 | 6.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 6 |
| Exact Mass | 400.334130642 g/mol |
| Monoisotopic Mass | 400.334130642 g/mol |
| Topological Polar Surface Area | 40.5 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 655 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
Treatment of secondary hyperparathyroidism (SHPT)
Calcidiol is the precursor of vitamin D3. Vitamin D3 is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.
Bone Density Conservation Agents
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)
Vitamins
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body. (See all compounds classified as Vitamins.)
A - Alimentary tract and metabolism
A11 - Vitamins
A11C - Vitamin a and d, incl. combinations of the two
A11CC - Vitamin d and analogues
A11CC06 - Calcifediol
H - Systemic hormonal preparations, excl. sex hormones and insulins
H05 - Calcium homeostasis
H05B - Anti-parathyroid agents
H05BX - Other anti-parathyroid agents
H05BX05 - Calcifediol
Absorption
Readily absorbed.
Calcidiol undergoes hydroxylation in the mitochondria of kidney tissue, and this reaction is activated by the renal 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to produce calcitriol (1,25- dihydroxycholecalciferol), the active form of vitamin D3.
288 hours
Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitriol, the active form of vitamin D3. Calcitriol binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.
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