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1. 1,24(oh)2-22-ene-24-cyclopropyl D3
2. Calcipotriene
3. Daivonex
4. Dovonex
5. Heximar Win Care
6. Mc 903
7. Mc-903
8. Pri-2205
9. Psorcutan
10. Sorilux
1. Calcipotriene
2. Dovonex
3. Daivonex
4. Sorilux
5. 112965-21-6
6. Calciptriol
7. Psorcutan
8. Calcipotriol Hydrate
9. Mc 903
10. Calcitrene
11. Mc-903
12. Calcipotriene [usan]
13. Calcipotriol [inn]
14. Calcipotriol Anhydrous
15. Chebi:50749
16. Dovonex (tn)
17. 112828-00-9
18. Pri-2201
19. Calcipotriol (jan)
20. 143nq3779b
21. (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(e,2r,5s)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
22. Ncgc00167465-01
23. Calcipotriol [jan]
24. Dsstox_cid_26648
25. Dsstox_rid_81793
26. Dsstox_gsid_46648
27. Divonex
28. (22e)-(24s)-1alpha,24-dihydroxy-26,27-cyclo-22,23-didehydrovitamin D3 / (22e)-(24s)-1alpha,24-dihydroxy-26,27-cyclo-22,23-didehydrocholecalciferol / Calcipotriol
29. (5z,7e,22e)-(1s,3r,24s)-26,27-cyclo-9,10-seco-5,7,10(19),22-cholestatetraene-1,3,24-triol
30. Smr000466353
31. Cas-112965-21-6
32. Sr-01000762910
33. Ccris 7700
34. Unii-143nq3779b
35. Pri 2201
36. Calcipotriene (usp)
37. Bms-181161
38. Calcipotrienemc 903
39. Calcipotriene [mi]
40. Epitope Id:114242
41. Schembl2853
42. Calcipotriene [vandf]
43. Calcipotriol [mart.]
44. Mls000759467
45. Mls001424130
46. Calcipotriol [who-dd]
47. Calcipotriene [usp-rs]
48. Gtpl2778
49. Chembl1200666
50. Dtxsid0046648
51. Amy2864
52. 1s19
53. Hms2051n11
54. Hms2089j08
55. Hms3269p03
56. Hms3413d04
57. Hms3677d04
58. Hms3713k08
59. Mc903
60. Calcipotriene [orange Book]
61. Calcipotriol [ep Monograph]
62. Ex-a4430
63. Zinc3921872
64. Tox21_112469
65. Bdbm50369964
66. Calcipotriene [usp Monograph]
67. Lmst03020106
68. S3739
69. Akos015855239
70. Tox21_112469_1
71. Ccg-100949
72. Cs-0387
73. Db02300
74. Nc00199
75. Stf-115469
76. Ncgc00167465-02
77. (5z,7e,22e,24s)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol
78. As-56390
79. Cpd000466353
80. Hy-10001
81. D01125
82. U-0267
83. Ab00698343-05
84. 828c009
85. Q155683
86. Sr-01000762910-3
87. Sr-01000762910-4
88. (1?,3?,5z,7e,22e,24s)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
89. (1s,3r,5z,7e,14beta,17alpha,22e,24s)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol
90. (5z,7e,22e,24s)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1.alpha.,3.beta.,24-triol
91. (5z,7e,24s)-26,27-cyclo-9,10-secocholesta-5,7,10(19),22-tetraene-1alpha,3beta,24-triol
92. 9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1.alpha.,3.beta.,5z,7e,22e,24s)-
93. 9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1alpha,3beta,5z,7e,22e,24s)-
Molecular Weight | 412.6 g/mol |
---|---|
Molecular Formula | C27H40O3 |
XLogP3 | 4.3 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 5 |
Exact Mass | 412.29774513 g/mol |
Monoisotopic Mass | 412.29774513 g/mol |
Topological Polar Surface Area | 60.7 Ų |
Heavy Atom Count | 30 |
Formal Charge | 0 |
Complexity | 743 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 7 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 3 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
1 of 6 | |
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Drug Name | Calcipotriene |
PubMed Health | Calcipotriene (On the skin) |
Drug Classes | Antipsoriatic |
Drug Label | Dovonex (calcipotriene solution) Scalp Solution, 0.005% is a colorless topical solution containing calcipotriene monohydrate, a synthetic vitamin D3 derivative, for topical dermatologic use.Chemically, calcipotriene monohydrate is (5Z,7E,22E,24S)... |
Active Ingredient | Calcipotriene |
Dosage Form | Ointment; Cream; Solution |
Route | Topical |
Strength | 0.005% |
Market Status | Prescription |
Company | Glenmark Generics; Fougera Pharms; Tolmar; G And W Labs |
2 of 6 | |
---|---|
Drug Name | Dovonex |
PubMed Health | Calcipotriene (On the skin) |
Drug Classes | Antipsoriatic |
Drug Label | Dovonex (calcipotriene solution) Scalp Solution, 0.005% is a colorless topical solution containing calcipotriene monohydrate, a synthetic vitamin D3 derivative, for topical dermatologic use.Chemically, calcipotriene monohydrate is (5Z,7E,22E,24S)... |
Active Ingredient | Calcipotriene |
Dosage Form | Cream |
Route | Topical |
Strength | 0.005% |
Market Status | Prescription |
Company | Leo Pharma As |
3 of 6 | |
---|---|
Drug Name | Sorilux |
PubMed Health | Calcipotriene (On the skin) |
Drug Classes | Antipsoriatic |
Drug Label | SORILUX Foam contains the compound calcipotriene, a synthetic vitamin D3 analog.Chemically, calcipotriene is (5Z,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5,7,10(19), 22-tetraene-1,3,24-triol. The structural formula is represented below:Molecular... |
Active Ingredient | Calcipotriene |
Dosage Form | Aerosol, foam |
Route | Topical |
Strength | 0.005% |
Market Status | Prescription |
Company | Stiefel Labs |
4 of 6 | |
---|---|
Drug Name | Calcipotriene |
PubMed Health | Calcipotriene (On the skin) |
Drug Classes | Antipsoriatic |
Drug Label | Dovonex (calcipotriene solution) Scalp Solution, 0.005% is a colorless topical solution containing calcipotriene monohydrate, a synthetic vitamin D3 derivative, for topical dermatologic use.Chemically, calcipotriene monohydrate is (5Z,7E,22E,24S)... |
Active Ingredient | Calcipotriene |
Dosage Form | Ointment; Cream; Solution |
Route | Topical |
Strength | 0.005% |
Market Status | Prescription |
Company | Glenmark Generics; Fougera Pharms; Tolmar; G And W Labs |
5 of 6 | |
---|---|
Drug Name | Dovonex |
PubMed Health | Calcipotriene (On the skin) |
Drug Classes | Antipsoriatic |
Drug Label | Dovonex (calcipotriene solution) Scalp Solution, 0.005% is a colorless topical solution containing calcipotriene monohydrate, a synthetic vitamin D3 derivative, for topical dermatologic use.Chemically, calcipotriene monohydrate is (5Z,7E,22E,24S)... |
Active Ingredient | Calcipotriene |
Dosage Form | Cream |
Route | Topical |
Strength | 0.005% |
Market Status | Prescription |
Company | Leo Pharma As |
6 of 6 | |
---|---|
Drug Name | Sorilux |
PubMed Health | Calcipotriene (On the skin) |
Drug Classes | Antipsoriatic |
Drug Label | SORILUX Foam contains the compound calcipotriene, a synthetic vitamin D3 analog.Chemically, calcipotriene is (5Z,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5,7,10(19), 22-tetraene-1,3,24-triol. The structural formula is represented below:Molecular... |
Active Ingredient | Calcipotriene |
Dosage Form | Aerosol, foam |
Route | Topical |
Strength | 0.005% |
Market Status | Prescription |
Company | Stiefel Labs |
For the treatment of moderate plaque psoriasis in adults.
Treatment of psoriasis
Calcipotriene is a synthetic analog of vitamin D. In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin.
Dermatologic Agents
Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)
D05AX52
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
D - Dermatologicals
D05 - Antipsoriatics
D05A - Antipsoriatics for topical use
D05AX - Other antipsoriatics for topical use
D05AX02 - Calcipotriol
Absorption
Clinical studies with radiolabeled ointment indicate that approximately 6% (+3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques or 5% (+2.6%, SO) when applied to normal skin.
Route of Elimination
The active form of the vitamin, 1,25-dihydroxy vitamin D3 (calcitriol), is known to be recycled via the liver and excreted in the bile. There is evidence that maternal 1,25-dihydroxy vitamin D3 (calcitriol) may enter the fetal circulation, but it is not known whether it is excreted in human milk.
Hepatic. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone. The primary metabolites are much less potent than the parent compound.
The precise mechanism of calcipotriol in remitting psoriasis is not well-understood, however, it has been shown to have comparable affinity with calcitriol for the Vitamin D receptor while being less than 1% the activity in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis and are believed to undergo modulation of gene expression with binding of calcipotriol to the VDR. This modulation is thought to affect gene products related to cell differentiation and proliferation.