1. Calcium Citrates
2. Citrate, Calcium
3. Citrates, Calcium
1. 813-94-5
2. Tricalcium Dicitrate
3. Tricalcium Citrate
4. Acicontral
5. Calcitrate
6. Calcium Citrate, Tribasic
7. Calcium Citrate Anhydrous
8. Calcium 2-hydroxy-1,2,3-propanetricarboxylate (3:2)
9. Tricalcium Citrate Tetrahydrate
10. Ins No.333(iii)
11. Ins-333(iii)
12. 2-hydroxy-1,2,3-propanetricarboxylic Acid Calcium Salt (2:3)
13. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Calcium Salt (2:3)
14. 86117bwo7p
15. E-333(iii)
16. Tricalcium;2-hydroxypropane-1,2,3-tricarboxylate
17. Calcimax
18. Citrical
19. Calcium (as Citrate)
20. Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3:2)
21. Tribasic Calcium Citrate
22. Calcium Citrate [usan]
23. 7693-13-2
24. Hsdb 5756
25. Citric Acid, Calcium Salt (2:3)
26. Einecs 212-391-7
27. Calciumcitrate
28. Unii-86117bwo7p
29. Lime Citrate
30. Calcium Citrate Powder
31. Calcium Citrate Tribasic
32. Calcium Citrate, Anhydrous
33. Ec 212-391-7
34. Calcium Citrate Usp, Fcc
35. Tricalcium Bis(citric Acid)
36. Calcium Citrate [mi]
37. Calcium Citrate [hsdb]
38. Chembl2106123
39. Dtxsid7061148
40. Calcium Citrate [who-dd]
41. Citric Acid Calcium Salt (2:3)
42. Chebi:190513
43. Mfcd00078618
44. Akos015839590
45. Db11093
46. Calcium Citrate Malate Glycinate 21% 40m
47. Q420280
48. Calcium Citrate Malate Carbonate 23%, Coarse Granu
49. J-509604
50. Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3/2)
51. Tricalcium Bis(2-hydroxypropane-1,2,3-tricarboxylic Acid)
| Molecular Weight | 498.4 g/mol |
|---|---|
| Molecular Formula | C12H10Ca3O14 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 4 |
| Exact Mass | 497.8948275 g/mol |
| Monoisotopic Mass | 497.8948275 g/mol |
| Topological Polar Surface Area | 281 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 211 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 5 |
For use as an over the counter calcium supplement.
FDA Label
Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone
Food Additives
Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS. (See all compounds classified as Food Additives.)
A - Alimentary tract and metabolism
A12 - Mineral supplements
A12A - Calcium
A12AA - Calcium
A12AA13 - Calcium citrate
Absorption
The percentage of calcium absorbed varies inversely with intake. Tmax of about 3.5-5h varying with formulation.
Route of Elimination
Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions.
Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
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