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1. Cyclamate
2. Cyclamate Calcium (2:1) Salt
3. Cyclamate, Calcium
4. Cyclamate, Calcium (2:1) Salt, Dihydrate
5. Cyclamate, Potassium
6. Cyclamate, Sodium
7. Cyclamate, Sodium Salt
8. Cyclamates
9. Cyclamic Acid
10. Potassium Cyclamate
11. Sodium Cyclamate
1. 139-06-0
2. Cyclamate Calcium
3. Cyclan
4. Calcium Bis(cyclohexylsulphamate)
5. Calcium Cyclohexanesulfamate
6. Calcium Cyclamate(1:2)
7. Calcium;n-cyclohexylsulfamate
8. X12lmj1wyl
9. Calcium Cyclamate Anhydrous
10. Dietil
11. Cylan
12. Sucaryl Calcium
13. Cyclamate, Calcium Salt
14. Kalziumzyklamate
15. Kalziumzyklamate [german]
16. Calcium Cyclohexylsulphamate
17. Calcium Cyclohexane Sulphamate
18. Ccris 186
19. Hsdb 823
20. Calcium Cyclohexylsulfamate (1:2)
21. Einecs 205-349-4
22. Unii-x12lmj1wyl
23. Ai3-52126
24. Cyclohexanesulfamic Acid, Calcium Salt (2:1)
25. Sulfamic Acid, Cyclohexyl-, Calcium Salt (2:1)
26. Calciumcyclohexylsulfamat
27. Calcium Cyclohexylsulfamate
28. Calcium Cyclamate [mi]
29. Schembl1532404
30. Calcium Cyclamate [hsdb]
31. Calcium Cyclamate [inci]
32. Chembl2104112
33. Dtxsid9057892
34. Cyclamate Calcium Anhydrous
35. Calcium Cyclamate, Anhydrous
36. Calcium N-cyclohexylsulphamate
37. Cyclohexylsulfamic Acid Calcium Salt
38. Db-042461
39. Ft-0631808
40. D02444
41. Sulfamic Acid, N-cyclohexyl-, Calcium Salt (2:1)
42. Q27293257
| Molecular Weight | 396.5 g/mol |
|---|---|
| Molecular Formula | C12H24CaN2O6S2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 2 |
| Exact Mass | 396.0701697 g/mol |
| Monoisotopic Mass | 396.0701697 g/mol |
| Topological Polar Surface Area | 155 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 187 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 3 |
2. 2= SLIGHTLY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-15 G/KG, BETWEEN 1 PINT & 1 QUART FOR 70 KG PERSON (150 LB).
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-406
Sweetening Agents
Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed) (See all compounds classified as Sweetening Agents.)
...PREVIOUSLY THOUGHT TO BE METABOLICALLY STABLE. WHEN GIVEN ORALLY TO GUINEA PIGS, RABBITS, RATS, & HUMANS ON CYCLAMATE-FREE DIET IT IS EXCRETED LARGELY UNCHANGED. /CYCLAMATE/
Testa, B. and P. Jenner. Drug Metabolism: Chemical & Biochemical Aspects. New York: Marcel Dekker, Inc., 1976., p. 449
...CYCLOHEXYLAMINE FORMED IN INTESTINE IS ALMOST COMPLETELY ABSORBED & EXCRETED IN URINE, IN COMPARISON TO CYCLAMATE, WHICH IS ABSORBED TO AN EXTENT OF ONLY 20-40%. /CYCLAMATE/
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 264
...(14)C-CYCLAMATE, GIVEN IV TO WOMEN UNDERGOING THERAPEUTIC ABORTION, BY ABDOMINAL HYSTERECTOMY DURING EARLY PREGNANCY, CROSSED PLACENTA & DISPERSED IN FETAL TISSUES, PARTICULARLY IN LIVER, SPLEEN, PANCREAS, & KIDNEYS. ...MATERNAL BLOOD LEVELS...FELL RAPIDLY...INDICATING VERY RAPID ELIMINATION... /CYCLAMATE/
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 150
MAX DAILY EXCRETION OF CYCLOHEXYLAMINE...RANGED FROM 0.1 TO 0.9% OF DAILY CYCLAMATE INTAKE (5 G); URINARY OUTPUT OF CYCLOHEXYLAMINE WAS ERRATIC & CONTINUED FOR 3-4 DAYS AFTER ADMIN HAD CEASED. /CYCLAMATE/
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 265
For more Absorption, Distribution and Excretion (Complete) data for CALCIUM CYCLAMATE (6 total), please visit the HSDB record page.
/CALCIUM/ CYCLAMATE LABELLED WITH (35)S OR (14)C IS EXCRETED BY MAN & LABORATORY ANIMALS ALMOST ENTIRELY UNCHANGED, IN URINE & FECES, ALTHOUGH TRACES OF...CYCLOHEXYLAMINE (0.7% DOSE) HAVE BEEN FOUND IN URINE OF HUMANS & DOGS DOSED ORALLY...
Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 165
...BIOTRANSFORMATION IN RATS...IS BROUGHT ABOUT BY GUT MICROFLORA. ...GUT MICROFLORA IN MAN & IN ANIMALS ACQUIRE CAPACITY TO METABOLIZE CYCLAMATE INTO CYCLOHEXYLAMINE, WHEN CYCLAMATE IS ADMIN CHRONICALLY. /CYCLAMATE/
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 264
GUT MICRO-ORGANISMS, WHICH BECOME CYCLAMATE "CONVERTERS" ARE CLOSTRIDIA IN RATS, ENTEROBACTERIA IN RABBITS, & ENTEROCOCCI IN MAN. /CYCLAMATE/
The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 347
...2 GROUPS OF WEANLING RATS WERE FED FOR 8 MO...WITH CHOW DIET OR...DIET CONTAINING 0.1% CA CYCLAMATE...THEN A SINGLE DOSE OF (14)C-CYCLAMATE BY STOMACH TUBE. ...7/11 CYCLAMATE-FED RATS CONVERTED CYCLAMATE INTO CYCLOHEXYLAMINE, TO...12-25% OF TOTAL (14)C IN URINE. 2 OF THE URINES CONTAINED TRACES OF DICYCLOHEXYLAMINE...
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 264
WHEN GUINEA PIGS, RABBITS, RATS, & HUMANS WERE PLACED ON A DIET CONTAINING CALCIUM CYCLAMATE THEY DEVELOPED THE ABILITY TO CONVERT ORALLY ADMIN CYCLAMATE INTO CYCLOHEXYLAMINE & THE METABOLITES OF THE LATTER.
RENWICK ET AL; BIOCHEM J 129(4) 869 (1972)
...IV DOSE OF 14(C)-CYCLAMATE TO PREGNANT RAT...T/2 OF CYCLAMATE WAS ABOUT 7 HR. /CYCLAMATE/
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 150
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