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    Camizestrant

    ACTIVE PHARMA INGREDIENTS

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    DIGITAL CONTENT

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    2D Structure
    Also known as: Azd-9833, Unii-jup57a8epz, Azd9833, 2222844-89-3, Camizestrant [usan], Jup57a8epz
    Molecular Formula
    C24H28F4N6
    Molecular Weight
    476.5  g/mol
    InChI Key
    WDHOIABIERMLGY-CMJOXMDJSA-N
    FDA UNII
    JUP57A8EPZ
    Camizestrant is an orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon administration, camizestrant binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This prevents ER-mediated signaling and inhibits the growth and survival of ER-expressing cancer cells.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine
    2.1.2 InChI
    InChI=1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1
    2.1.3 InChI Key
    WDHOIABIERMLGY-CMJOXMDJSA-N
    2.1.4 Canonical SMILES
    CC1CC2=C(C=CC3=C2C=NN3)C(N1CC(F)(F)F)C4=NC=C(C=C4)NC5CN(C5)CCCF
    2.1.5 Isomeric SMILES
    C[C@@H]1CC2=C(C=CC3=C2C=NN3)[C@H](N1CC(F)(F)F)C4=NC=C(C=C4)NC5CN(C5)CCCF
    2.2 Other Identifiers
    2.2.1 UNII
    JUP57A8EPZ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Azd-9833

    2. Azd9833

    3. N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6s,8r)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo(4,3-f)isoquinolin-6-yl)pyridin-3-amine

    2.3.2 Depositor-Supplied Synonyms

    1. Azd-9833

    2. Unii-jup57a8epz

    3. Azd9833

    4. 2222844-89-3

    5. Camizestrant [usan]

    6. Jup57a8epz

    7. Az14066724

    8. Az-14066724

    9. N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6s,8r)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine

    10. 3-pyridinamine, N-(1-(3-fluoropropyl)-3-azetidinyl)-6-((6s,8r)-6,7,8,9-tetrahydro-8-methyl-7-(2,2,2-trifluoroethyl)-3h-pyrazolo(4,3-f)isoquinolin-6-yl)-

    11. Camizestrant [inn]

    12. Camizestrant [who-dd]

    13. Chembl4650365

    14. Schembl20089710

    15. Ex-a5025

    16. Nsc828717

    17. Who 11592

    18. At22885

    19. Nsc-828717

    20. Hy-136255

    21. Cs-0121043

    22. N-(1-(3-fluoropropyl)-3-azetidinyl)-6-((6s,8r)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3h-pyrazolo(4,3-f)isoquinolin-6-yl)-3-pyridinamine

    23. N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6s,8r)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine

    2.4 Create Date
    2018-06-23
    3 Chemical and Physical Properties
    Molecular Weight 476.5 g/mol
    Molecular Formula C24H28F4N6
    XLogP34.2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count7
    Exact Mass476.23115757 g/mol
    Monoisotopic Mass476.23115757 g/mol
    Topological Polar Surface Area60.1 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity674
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1