1. D 1694
2. D-1694
3. D1694
4. Ici D1694
5. Ici-d1694
6. N-(5-(n-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-n-methylamino)-2-thenoyl)-l-glutamic Acid
7. Tomudex
8. Zd 1694
9. Zd-1694
10. Zd1694
1. Tomudex
2. 112887-68-0
3. Zd1694
4. Zd-1694
5. Ici-d1694
6. D-1694
7. D1694
8. Ici D1694
9. Zd-16
10. Chebi:5847
11. (2s)-2-[[5-[methyl-[(2-methyl-4-oxo-1h-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic Acid
12. Raltitrexed (tomudex)
13. Fcb9egg971
14. Zd 1694
15. Chembl225071
16. N-(5-(n-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-n-methylamino)-2-thenoyl)-l-glutamic Acid
17. Ici-d-1694
18. Nsc-639186
19. N-(5-(((3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thenoyl)-l-glutamic Acid
20. Ncgc00229704-01
21. Dsstox_cid_26482
22. Dsstox_rid_81653
23. Dsstox_gsid_46482
24. (s)-2-(5-(methyl((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-methyl)amino)thiophene-2-carboxamido)pentanedioic Acid
25. (s)-2-(5-(methyl((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic Acid
26. L-glutamic Acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)-
27. N-(5-[n-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-n-methylamino]-2-thenoyl)-l-glutamic Acid
28. (2s)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic Acid
29. (2s)-2-[[5-[methyl-[(2-methyl-4-oxo-3h-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic Acid
30. D16
31. Tomudex (tn)
32. D 1694
33. Cas-112887-68-0
34. Unii-fcb9egg971
35. Raltitrexed (jan/usan/inn)
36. 1hvy
37. 2kce
38. 2tsr
39. Zn-d1694
40. Ks-5069
41. Zd1694; Raltitrexed
42. Raltitrexed [mi]
43. Raltitrexed [inn]
44. Raltitrexed [jan]
45. Raltitrexed [usan]
46. Schembl7438
47. Raltitrexed [mart.]
48. Raltitrexed [who-dd]
49. Mls001424225
50. Mls006010125
51. Raltitrexed [usan:inn:ban]
52. Gtpl7403
53. Dtxsid0046482
54. Bdbm18795
55. 1i00
56. Hms2052i03
57. Hms3715p08
58. (s)-2-(5-(methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic Acid
59. Amy42113
60. Zinc3832372
61. Tox21_112237
62. Bdbm50027655
63. Mfcd00864168
64. Nsc639186
65. S1192
66. Akos015894877
67. Akos015994729
68. Tox21_112237_1
69. Ccg-101075
70. Ccg-221273
71. Db00293
72. Nc00325
73. Ncgc00263534-02
74. Hy-10821
75. L-glutamic Acid, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-
76. Nci60_013008
77. Smr000469217
78. Smr002529608
79. Bcp0726000267
80. R0208
81. Sw197705-2
82. D01064
83. Ab00698356-05
84. 887r680
85. Sr-01000763351
86. J-524216
87. Sr-01000763351-3
88. Brd-k89839824-001-01-2
89. Q15304877
90. N-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)carbonyl]-l-glutamic Acid
91. N-[[5-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-l-glutamic Acid
| Molecular Weight | 458.5 g/mol |
|---|---|
| Molecular Formula | C21H22N4O6S |
| XLogP3 | 1.4 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 9 |
| Exact Mass | 458.12600561 g/mol |
| Monoisotopic Mass | 458.12600561 g/mol |
| Topological Polar Surface Area | 177 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 790 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of malignant neoplasm of colon and rectum
Mesothelioma of the pleura
Raltitrexed belongs to a group of medicines known as antimetabolites. It is used to treat cancer of the colon and rectum. It may also be used to treat other kinds of cancer, as determined by your doctor. Raltitrexed blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by raltitrexed, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.
Antimetabolites, Antineoplastic
Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)
Folic Acid Antagonists
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Folic Acid Antagonists.)
L01BA03
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
L - Antineoplastic and immunomodulating agents
L01 - Antineoplastic agents
L01B - Antimetabolites
L01BA - Folic acid analogues
L01BA03 - Raltitrexed
Raltitrexed is transported into cells via a reduced folate carrier. Inside the cell it is extensively polyglutamated by the enzyme folyl polyglutamate synthetase to polyglutamate forms.
198 hours
Raltitrexed is an antineoplastic Agents and folic acid antagonists. Raltitrexed inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier. Inside the cell Raltitrexed is extensively polyglutamated, which enhances thymidylate synthase inhibitory power and duration. Inhibition of this enzyme results in decreased synthesis of thymidine triphosphate which is required for DNA synthesis.
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