1. Cellcept
2. Mofetil Hydrochloride, Mycophenolate
3. Mofetil, Mycophenolate
4. Mycophenolate Mofetil
5. Mycophenolate Mofetil Hydrochloride
6. Mycophenolate Sodium
7. Mycophenolate, Sodium
8. Mycophenolic Acid Morpholinoethyl Ester
9. Myfortic
10. Rs 61443
11. Rs-61443
12. Rs61443
13. Sodium Mycophenolate
1. 24280-93-1
2. Mycophenolate
3. Myfortic
4. Melbex
5. Mycophenolsaeure
6. 483-60-3
7. Lilly-68618
8. 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid
9. Nsc-129185
10. Acido Micofenolico
11. Micofenolico Acido
12. Acide Mycophenolique
13. Acidum Mycophenolicum
14. (4e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic Acid
15. Ccris 5565
16. Nsc 129185
17. Ly 68618
18. (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid
19. (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic Acid
20. (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1h-2-benzofuran-5-yl)-4-methylhex-4-enoic Acid
21. Mfcd00036814
22. Lilly 68618
23. 4-hexenoic Acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (e)-
24. Chembl866
25. Hu9dx48n0t
26. 6-(1,3-dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic Acid
27. Chebi:168396
28. Tnp00198
29. Rs-61443 [as Mofetil]
30. Nsc129185
31. 4-hexenoic Acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (e)-
32. 4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide (e)-
33. 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methylhex-4-enoic Acid
34. 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid (e)-
35. 4-hexenoic Acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (4e)-
36. Ncgc00016786-01
37. Cas-24280-93-1
38. Mycophenolic Acid 100 Microg/ml In Acetonitrile
39. Dsstox_cid_21070
40. Dsstox_rid_79619
41. Dsstox_gsid_41070
42. Mycophenolic Acid-d3 Solution
43. Mycophenoic Acid
44. 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1h-isobenzofuran-5-yl)-4-methyl-4-hexenoic Acid
45. Micofenolico Acido [spanish]
46. (4e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic Acid (mycophenolic Acid)
47. (e)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid
48. 4-hexenoic Acid,6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (4e)-
49. 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid
50. 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic Acid
51. Moa
52. Smr000471887
53. Acido Micofenolico [inn-spanish]
54. Acide Mycophenolique [inn-french]
55. Acidum Mycophenolicum [inn-latin]
56. Sr-01000597602
57. Einecs 246-119-3
58. Unii-hu9dx48n0t
59. Mycophenolic-acid
60. Prestwick_817
61. Einecs 207-595-8
62. Mycophenolic Acid [usan:inn:ban]
63. Tocris-1505
64. (z)-mycophenolic Acid
65. 1jr1
66. Starbld0040186
67. Mycophenolic Acid (tn)
68. Prestwick2_000556
69. Prestwick3_000556
70. Spectrum5_001654
71. Mycophenolic Acid (mpa)
72. Mycophenolic Acid Solution
73. Upcmld-dp028
74. 4-hexenoic Acid, (e)-
75. Ec 246-119-3
76. Mycophenolate;rs-61443
77. Schembl4549
78. Mycophenolic (mycophenolate)
79. Mycophenolic Acid, >=98%
80. Bspbio_000631
81. Bspbio_002534
82. Mycophenolate [vandf]
83. Mls001074701
84. Mls002222265
85. Mls002695945
86. Bidd:gt0456
87. Spectrum1500674
88. Mycophenolic Acid [mi]
89. Bpbio1_000695
90. Gtpl6832
91. Megxm0_000120
92. Mycophenolic Acid (usan/inn)
93. Myfortic (mycophenolate Sodium)
94. Schembl2514376
95. Zinc1758
96. Mycophenolic Acid [inn]
97. Dtxsid4041070
98. Mycophenolic Acid [usan]
99. Upcmld-dp028:001
100. Acon0_000960
101. Acon1_000496
102. Bdbm19264
103. Chebi:92545
104. Hms500h08
105. Ex-a975
106. Mycophenolic Acid [vandf]
107. Mycophenolic Acid [mart.]
108. Hms1569p13
109. Hms1921a18
110. Hms2089a17
111. Hms2092g22
112. Hms2096p13
113. Hms2268h22
114. Hms3403p09
115. Hms3412f09
116. Hms3676f09
117. Pharmakon1600-01500674
118. Mycophenolic Acid [who-dd]
119. Act02623
120. Amy40494
121. Bcp05321
122. Hy-b0421
123. Tox21_110610
124. Bbl034696
125. Ccg-39914
126. Nsc757424
127. S2487
128. Stl419986
129. Mycophenolic Acid, Analytical Standard
130. Akos015888214
131. Tox21_110610_1
132. Ac-4491
133. Bcp9000970
134. Db01024
135. Ds-1638
136. Mycophenolic Acid [orange Book]
137. Nsc-757424
138. Sdccgmls-0066618.p001
139. (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1h-isobenzofuran-5-yl)-4-methyl-hex-4-enoic Acid
140. Idi1_000146
141. Ncgc00016786-02
142. Ncgc00016786-03
143. Ncgc00016786-04
144. Ncgc00016786-05
145. Ncgc00016786-06
146. Ncgc00016786-07
147. Ncgc00016786-08
148. Ncgc00016786-09
149. Ncgc00016786-10
150. Ncgc00016786-11
151. Ncgc00016786-12
152. Ncgc00016786-15
153. Ncgc00025190-01
154. Ncgc00025190-02
155. Ncgc00025190-03
156. Ncgc00025190-04
157. Ncgc00025190-05
158. Ncgc00025190-07
159. Ncgc00025190-08
160. Ncgc00025190-09
161. Ncgc00025190-10
162. (4e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxohydroisobenzofuran-5-yl)-4-methylhex -4-enoic Acid
163. Bm164624
164. Mycophenolic Acid - Cas 24280-93-1
165. Sbi-0051945.p003
166. A-249
167. M2216
168. Sw196951-2
169. C20380
170. D05096
171. M 5255
172. M02087
173. Ab00052466-13
174. Ab00052466-14
175. Ab00052466_15
176. Ab00052466_16
177. 280m931
178. A817192
179. Mycophenolate Mofetil Impurity, Mycophenolic Acid-
180. Q420553
181. Sr-01000597602-1
182. Sr-01000597602-3
183. Sr-01000597602-4
184. Brd-k63750851-001-06-6
185. Brd-k63750851-001-13-2
186. Mycophenolate Mofetil Impurity F [ep Impurity]
187. Mycophenolate Mofetil Impurity, Mycophenolic Acid- [usp Impurity]
188. Mycophenolic Acid, Powder, Bioreagent, Suitable For Cell Culture, >=98%
189. 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid;nsc 129185
190. 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthanlanyl)-4-methyl-4-hexanoic Acid
191. (e)-6-(1,3-dihydro-4-hydroxy-6- Methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methyl-4-hexenoic Acid
192. (e)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methyl-4-hexenoic Acid
193. 1162256-90-7
194. 4-hexenoic Acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (4e)- (9ci)
195. 4-hexenoic Acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (e)- (8ci)
196. 4-hexenoic Acid,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5- Isobenzofuranyl)-4-methyl-, (e)-
197. 4-methyl-6-[3-oxo-7-methyl-4-hydroxy-6-methoxy-1,3-dihydroisobenzofuran-5-yl]-4-hexenoic Acid
198. E-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid
199. Mycophenolic Acid Solution, 1.0 Mg/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 320.3 g/mol |
|---|---|
| Molecular Formula | C17H20O6 |
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 6 |
| Exact Mass | 320.12598835 g/mol |
| Monoisotopic Mass | 320.12598835 g/mol |
| Topological Polar Surface Area | 93.1 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 486 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the prophylaxis of organ rejection in patients receiving allogeneic renal transplants, administered in combination with cyclosporine and corticosteroids.
Mycophenolic acid is an antibiotic substance derived from Penicillium stoloniferum. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites.
Antibiotics, Antitubercular
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic. (See all compounds classified as Antibiotics, Antitubercular.)
Antibiotics, Antineoplastic
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
L - Antineoplastic and immunomodulating agents
L04 - Immunosuppressants
L04A - Immunosuppressants
L04AA - Selective immunosuppressants
L04AA06 - Mycophenolic acid
Absorption
Bioavailability following oral administration of Myfortic delayed-release tablet ranges from 70-95%
Volume of Distribution
54 25 L
Clearance
140 +/- 30 mL/min [Stable renal transplant patients]
Mycophenolic acid is metabolized mainly by glucuronyl transferase to glucuronidated metabolites, predominantly the phenolic glucuronide, mycophenolic acid glucuronide (MPAG). MPAG does not manifest pharmacological activity. The acyl glucuronide minor metabolite has pharmacological activity similar to mycophenolic acid. The AUC ratio of Mycophenolic acid:MPAG:acyl glucuronide is approximately 1:24:0.28 at steady state.
Mycophenolic acid has known human metabolites that include 6-O-desmethyl-MPA (DM-MPA) and Mycophenolic acid glucuronide.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
The mean elimination half-life for mycophenolic acid ranges from 8-16 hours, while that of the MPAG metabolite ranges from 13-17 hours.
Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, mycophenolic acid has potent cytostatic effects on lymphocytes. Mycophenolic acid inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of mycophenolic acid on lymphocytes. Mycophenolic acid also suppresses antibody formation by B-lymphocytes. Mycophenolic acid prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection.
LOOKING FOR A SUPPLIER?
