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1. 1 Aminocyclopentanecarboxylic Acid
2. 1-aminocyclopentanecarboxylic Acid
3. Acid, 1-aminocyclopentanecarboxylic
4. Acid, Aminocyclopentanecarboxylic
5. Aminocyclopentanecarboxylic Acid
6. Nsc 1026
1. 1-aminocyclopentanecarboxylic Acid
2. 52-52-8
3. Cycloleucin
4. 1-aminocyclopentane-1-carboxylic Acid
5. 1-amino-1-cyclopentanecarboxylic Acid
6. 1-amino-1-carboxycyclopentane
7. Cyclo-leucine
8. 1-amino-cyclopentanecarboxylic Acid
9. Cyclopentanecarboxylic Acid, 1-amino-
10. Nsc 1026
11. Cb 1639
12. X 201
13. 1-aminocyclopentanecarboxylate
14. Wr 14,997
15. Nsc1026
16. Mfcd00001381
17. Aminocyclopentanecarboxylic Acid
18. 0tqu7668ei
19. Chembl295830
20. Chebi:40547
21. Cycloleucine1-amino-cyclopentanecarboxylic Acid
22. 1-amino-1-cyclopentanecarboxylate
23. Nsc-1026
24. 1-amino-1-cyclopentane Carboxylic Acid
25. Wr 14997
26. 1-aminocyclopentane-1-carboxylate
27. 1-ammonio-1-cyclopentanecarboxylate
28. Hsdb 5195
29. 1-amino Cyclopentane Carboxylic Acid
30. Einecs 200-144-6
31. Brn 0636626
32. Unii-0tqu7668ei
33. A829129
34. Ai3-26442
35. Cyclopentanecarboxylic Acid, 1-amino-, L-
36. Leucine, Cyclo-
37. 1-aminocyclopentane Carboxylic Acid
38. Cycloleucine, 97%
39. (2e)-decenoyl-acp
40. Spectrum_001268
41. 1y1m
42. H-nh(1)cpen-oh
43. Ac1ocg3t
44. Spectrum2_000931
45. Spectrum3_001514
46. Spectrum4_000340
47. Spectrum5_001136
48. Cycloleucine [mi]
49. Biomol-nt_000201
50. Cycloleucine [hsdb]
51. Ncimech_000677
52. Wln: L5tj Az Avq
53. Schembl8495
54. Bspbio_003187
55. Cycloleucin [who-dd]
56. Kbiogr_000719
57. Kbioss_001748
58. 4-14-00-00974 (beilstein Handbook Reference)
59. Divk1c_000723
60. Spectrum1502128
61. Spbio_000862
62. 1-amino-cyclopentanecarboxylate
63. Bpbio1_001084
64. Zinc1234
65. Cyclopentanecarboxylic Acid, L-
66. 1-aminocyclopentanecarboxylicacid
67. Acid, Aminocyclopentanecarboxylic
68. Dtxsid5024475
69. Hms502e05
70. Kbio1_000723
71. Kbio2_001748
72. Kbio2_004316
73. Kbio2_006884
74. Kbio3_002687
75. Nilqlfbwtxnuoe-uhfffaoysa-
76. 1 Aminocyclopentanecarboxylic Acid
77. Ninds_000723
78. Hms1921l08
79. Acid, 1-aminocyclopentanecarboxylic
80. Act04362
81. Albb-035361
82. Cs-b0093
83. 1-amino-cyclopentane Carboxylic Acid
84. Bbl020454
85. Bdbm50070638
86. Ccg-35835
87. Fd1031
88. Stk133034
89. Zinc00001234
90. Akos000183252
91. Ac-2700
92. Cb-1639
93. Db04620
94. Idi1_000723
95. Ncgc00094966-01
96. Ncgc00094966-02
97. Ncgc00094966-03
98. Ncgc00094966-04
99. Ncgc00163268-01
100. Ncgc00178218-01
101. Ac5
102. As-11677
103. Hy-30008
104. Nci60_000070
105. Sy002601
106. Cycloleucine1-amino-cyclopentanecarboxylate
107. Cyclopentanecarboxylic Acid, L-amino
108. Db-031284
109. Am20100281
110. Ft-0607341
111. En300-39470
112. C03969
113. 001c381
114. Q607775
115. J-504199
116. J-802019
117. F8881-4536
118. 3dd7e30b-2149-43d9-a44b-7a59d546a28b
| Molecular Weight | 129.16 g/mol |
|---|---|
| Molecular Formula | C6H11NO2 |
| XLogP3 | -2.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 129.078978594 g/mol |
| Monoisotopic Mass | 129.078978594 g/mol |
| Topological Polar Surface Area | 63.3 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 127 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
EXPTL USE (VET): SINGLE DOSES OF ANTILYMPHOCYTE SERUM, CYCLOPHOSPHAMIDE, CYCLOLEUCINE DELAYED ONSET OF HYPERACUTE FORM OF EXPTL ALLERGIC ENCEPHALOMYELITIS IN RATS. CYCLOLEUCINE & TILORONE-HCL WERE PROVEN TO HAVE SYNERGISTIC RELATIONSHIP.
LEVINE S, SOWINSKI R; PROC SOC EXP BIOL MED 156(3) 457 (1977)
EXPTL USE: (11)C-CYCLOLEUCINE WAS EVALUATED AS TUMOR SCANNING AGENT IN 38 PT. EXTRAPOLATION FROM ANIMAL DATA GIVES 0.01 RAD/UCI FOR WHOLE BODY & LESS THAN 0.06 RAD/UCI FOR PANCREAS. 33/38 HAS GALLIUM CITRATE (67)GA SCANS ALSO; RESULTS 19 POS FORMER & 24 POS (67)GA SCANS.
HUBNER ET AL; J NUCL MED 18(DEC) 1215 (1977)
MEDICATION (VET): CARBOXYL-LABELED (11)C-CYCLOLEUCINE WAS PREPD IN MULTIMILLICURIE AMT. TISSUE DISTRIBUTION (750 MICROCURIE, IV) IN MORRIS 5123 C HEPATOMA BEARING RATS INDICATED THE COMPD HAS POTENTIAL AS TUMOR-LOCALIZING AGENT FOR DETECTING CANCER IN HUMANS.
HAYES ET AL; J NUCL MED 17(8) 748 (1976)
MEDICATION (VET): CYCLOLEUCINE PROTECTED RATS AGAINST SEIZURES IN MAXIMAL ELECTROSHOCK TEST BUT OFFERED NO PROTECTION AGAINST METRAZOL-(PENTYLENETETRAZOL) INDUCED SEIZURES IN MICE.
ZAN R, IZQUIERDO I; NEUROCHEM RES 5(1) 1 (1980)
Cycloleucine has cytostatic, immunosuppressive and antineoplastic activities.
LEVELS OF (14)C IN LIVER & PANCREAS WERE RESPECTIVELY EIGHTFOLD & TWOFOLD THOSE IN BLOOD, 15 MIN AFTER IV DOSE OF [(14)C]-1-AMINOCYCLOPENTANECARBOXYLIC ACID TO RHESUS MONKEYS. (14)C LEVELS IN THESE TISSUES WERE SIMILAR TO THOSE IN BLOOD AFTER 24 HR.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 122
WHEN ADMIN TO MICE CYCLOLEUCINE ACCUM IN TISSUES AT LEVELS BETWEEN 0.02 & 1.29 MG/ML. MOST OF REMAINING 2% WAS ASSOC WITH PROTEIN. ACCUM AGAINST CONCN GRADIENT OCCURRED IN KIDNEY, IN SPLEEN TO GREATER EXTENT & TO MUCH GREATER DEGREE IN PANCREAS. THE DISTRIBUTION RATIOS FOR CNS TISSUE, KIDNEY & SPLEEN DID NOT CHANGE AS FUNCTION OF PLASMA CYCLOLEUCINE CONCN OR OF TIME BETWEEN 4 & 40 DAYS AFTER ADMIN TO MICE. 5 DAYS AFTER ADMIN OF CYCLOLEUCINE TO MICE, HEPATIC CYCLOLEUCINE DISTRIBUTION RATIO WAS CONSIDERABLY GREATER THAN UNITY AT THE LOWEST DOSES & INCR VARIABLY WITH INCR CYCLOLEUCINE PLASMA LEVELS.
NIXON RA; BIOCHEM PHARMACOL 25(6) 726 (1976)
AT 0.4-0.5 MG/G PLASMA LEVEL AT 24 DAYS WAS NOT SIGNIFICANTLY DIFFERENT FROM THAT AT 1 DAY. HIGHEST DOSES (1-3 MG/G) RESULTED IN NEARLY SIMILAR PLASMA LEVELS BY 4TH DAY. T/2 IN PLASMA WAS EXTREMELY LONG.
NIXON RA; BIOCHEM PHARMACOL 25(6) 726 (1976)
SYNTHETIC AMINO ACID THOUGHT TO ACT AS VALINE ANTAGONIST.
The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 357
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