1. 17 Alpha Hydroxyprogesterone
2. 17 Alpha-hydroxyprogesterone
3. 17 Hydroxyprogesterone
4. 17-alpha-hydroxyprogesterone
5. 17-hydroxyprogesterone
6. 17-hydroxyprogesterone, (17 Alpha)-isomer
7. 17-hydroxyprogesterone, (9 Beta, 10 Alpha)-isomer
1. 17alpha-hydroxyprogesterone
2. 68-96-2
3. 17-hydroxyprogesterone
4. 17a-hydroxyprogesterone
5. Prodix
6. Prodox
7. Gestageno Gador
8. 17-alpha-hydroxyprogesterone
9. 17-hydroxypregn-4-ene-3,20-dione
10. Pregn-4-ene-3,20-dione, 17-hydroxy-
11. Setaderm
12. Oxiprogesteronum
13. 17alpha-hydroxy-progesterone
14. 17alpha-hydroxy-4-pregnene-3,20-dione
15. Hidroxiprogesterona
16. Hydroxyprogesteronum
17. Pregn-4-ene-3,20-dione-17-ol
18. Gestageno
19. Idrossiprogesterone [dcit]
20. Delta(4)-pregnene-17alpha-ol-3,20-dione
21. 17
22. A-hydroxyprogesterone
23. Hydroxyprogesteronum [inn-latin]
24. Hidroxiprogesterona [inn-spanish]
25. 17-oh Progesterone
26. 17-hydroxypregn-4-en-3,20-dione
27. 17.alpha.-hydroxyprogesterone
28. Hsdb 3343
29. 604-09-1
30. Chebi:17252
31. Nsc-15468
32. Mls000028453
33. 17-ohp
34. (8r,9s,10r,13s,14s,17r)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one
35. 4-pregnen-17a-ol-3,20-dione
36. U 3096
37. Pregn-4-ene-3,20-dione, 17-hydroxy-, (17a)-
38. 4-pregnen-17alpha-ol-3,20-dione
39. Delta4-pregnen-17alpha-ol-3,20-dione
40. Ncgc00093949-03
41. Alpha-17hydroxypregn-4-ene-3,20-dione
42. Smr000058349
43. 21807m87j2
44. Hydroxyprogesterone (inn)
45. (9beta)-17-hydroxypregn-4-ene-3,20-dione
46. U-3096
47. Dsstox_cid_20747
48. Dsstox_rid_79586
49. Dsstox_gsid_40747
50. Hydroxyprogesterone [inn]
51. Alpha Hydroxy Progesterone
52. Idrossiprogesterone
53. Cas-68-96-2
54. 17ohp
55. Hydroxyprogesterone [inn:ban]
56. Einecs 200-699-4
57. Nsc 15468
58. 17alpha Hydroxyprogesterone
59. Brn 2062088
60. Mfcd00003659
61. Unii-21807m87j2
62. 3qz
63. 17a-hydroxypregn-4-ene-3,20-dione
64. 17-hydroxy-progesterone
65. 17-a-hydroxyprogesterone
66. Opera_id_1812
67. 17?-hydroxy Progesterone
68. Bmse000472
69. Bmse000598
70. Epitope Id:152220
71. Schembl8068
72. Chembl1062
73. Bidd:pxr0103
74. Lopac0_000565
75. 17.alpha.-hydoxyprogesterone
76. 4-08-00-02189 (beilstein Handbook Reference)
77. Mls001076300
78. Mls002695950
79. Gtpl5104
80. Progesterone, 17alpha-hydroxy-
81. Dtxsid6040747
82. Pregn-4-ene-3,20-dione, 17-hydroxy-, (17.alpha.)-
83. Pregn-4-ene-3, 17-hydroxy-
84. Dtxsid00859075
85. Hydroxyprogesterone [hsdb]
86. Hms2090m08
87. Hms2234j04
88. Hms3261b12
89. Hydroxyprogesterone [vandf]
90. D4-pregnen-17a-ol-3,20-dione
91. Hy-b0891
92. Nsc15468
93. Pregn-4-en-17a-ol-3,20-dione
94. Zinc5434436
95. Hydroxyprogesterone [who-dd]
96. Tox21_111233
97. Tox21_301530
98. Tox21_500565
99. Bdbm50423511
100. Lmst02030161
101. S4507
102. 17alpha-hydroxyprogesterone, >=95%
103. Akos015955623
104. Tox21_111233_1
105. Ccg-204655
106. Cs-4354
107. Db14570
108. Fd12004
109. Ks-5312
110. Lp00565
111. Sdccgsbi-0050548.p002
112. 4-pregnen-17.alpha.-ol-3,20-dione
113. Ncgc00093949-04
114. Ncgc00093949-05
115. Ncgc00093949-08
116. Ncgc00255425-01
117. Ncgc00261250-01
118. 17alpha-hydroxy-pregn-4-ene-3,20-dione
119. 17.alpha.-hydroxyprogesterone [mi]
120. 17.alpha.-hydroxypregna-4-ene-3,20-dione
121. Eu-0100565
122. H1250
123. C01176
124. D08052
125. H 5752
126. 17-hydroxypregn-4-ene-3,20-dione, (+/-)-
127. Ab00490003-08
128. Q175901
129. 17.alpha.-hydroxypregn-4-ene-3,20-dione
130. W-104646
131. 17-hydroxypregn-4-ene-3,20-dione-, (17.alpha.)-
132. 7a45bef6-add0-4b3e-a014-2de930d3b67b
133. 17-alpha-hydroxyprogesterone 100 Microg/ml In Methanol
134. 17alpha-hydroxyprogesterone, Vetranal(tm), Analytical Standard
135. (1s,2r,10r,11s,14r,15s)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
136. (8r,10r,13s,17r)-17-acetyl-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
137. (8r,9s,10r,13s,14s,17r)-17-acetyl-17-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3(2h)-one
138. 110850-01-6
139. 17alpha-hydroxyprogesterone Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 330.5 g/mol |
|---|---|
| Molecular Formula | C21H30O3 |
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 330.21949481 g/mol |
| Monoisotopic Mass | 330.21949481 g/mol |
| Topological Polar Surface Area | 54.4 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 635 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
THERAPEUTIC USES. ...CONTRACEPTION...FUNCTIONAL UTERINE BLEEDING... DYSMENORRHEA...PREMENSTRUAL TENSION...ENDOMETRIOSIS...THREATENED & HABITUAL ABORTION...EVALUATION OF OVARIAN FUNCTION & DIAGNOSIS OF PREGNANCY...SUPPRESSION OF POST-PARTUM LACTATION...ENDOMETRIAL CARCINOMA. /PROGESTINS/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1439
CHEMOTHERAPEUTIC AGENTS USEFUL IN NEOPLASTIC DISEASE: HYDROXYPROGESTERONE CAPROATE (DELALUTIN) FOR ENDOMETRIUM, RENAL CELL, BREAST, PROSTATE. /CAPROATE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1251
...IN METASTATIC & RECURRENT ENDOMETRIAL CARCINOMA. THEY PRODUCE REMISSIONS FOR PROLONGED PERIODS IN ABOUT 25% OF PT WHEN METASTASES ARE CONFINED TO PULMONARY AREA. LARGER DOSES...WHEN DISEASE RECURS IN OSSEOUS, INTRA-ABDOMINAL, OR PELVIC SITES. ...USED PARENTERALLY IN RENAL CARCINOMA. /PROGESTAGEUS/
American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 1142
WHEN USED TO REGULATE IRREGULAR ESTRUS CYCLE, IT IS USUALLY COMBINED WITH ESTROGEN. /CAPROATE/
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 922
For more Therapeutic Uses (Complete) data for 17ALPHA-HYDROXYPROGESTERONE (15 total), please visit the HSDB record page.
VET: AVOID BREEDING TREATED ANIMALS UNTIL SECOND POST-TREATMENT ESTRUS CYCLE. SEVERE PYOMETRA-LIKE SYNDROMES HAVE OCCURRED IN TREATED ANIMALS DEPRIVED OF NORMAL ESTRUS STIMULATING EFFECTS ON UTERINE ENDOMETRIUM...
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 269
WHETHER TAKING ORAL CONTRACEPTIVES OF PROGESTIN-ESTROGEN TYPE PRODUCED HIGHER INCIDENCE OF OCULAR & OPHTHALMO-NEUROLOGIC DISEASES THAN WOULD OCCUR SPONTANEOUSLY IN UNMEDICATED WOMEN OR IN PREGNANT WOMEN WAS NOT ANSWERED CONCLUSIVELY... /PROGESTINS/
Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974., p. 307
CONTRAINDICATIONS TO THEIR USE ARE THROMBOEMBOLIC DISORDERS OR PAST HISTORY OF THESE CONDITIONS, MARKEDLY IMPAIRED HEPATIC FUNCTION, KNOWN OR SUSPECTED CARCINOMA OF BREAST OR OTHER ESTROGEN-DEPENDENT NEOPLASIA, & UNDIAGNOSED GENITAL BLEEDING. /ORAL CONTRACEPTIVES/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1447
G - Genito urinary system and sex hormones
G03 - Sex hormones and modulators of the genital system
G03D - Progestogens
G03DA - Pregnen (4) derivatives
G03DA03 - Hydroxyprogesterone
...DURATION OF ACTION IS LONGER /THAN PROGESTERONE/, BUT ITS ONSET OF ACTION IS SLOWER. SINGLE INJECTION OF SOLN OF HYDROXYPROGESTERONE CAPROATE IN OIL WILL EXERT PROGESTATIONAL EFFECTS FOR 1-2 WK. /CAPROATE/
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 922
ABOUT 50-60% OF ADMIN RADIOACTIVE PROGESTERONE APPEARS IN URINE & ABOUT 10% IN FECES. ... WHEN PROGESTERONE IS GIVEN FOR PROLONGED PERIOD, DURING LUTEAL PHASE OF CYCLE, OR DURING PREGNANCY, LARGER PROPORTION (25-30%) APPEARS IN URINE AS PREGUANEDIOL. /PROGESTERONE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1439
RATE OF TURNOVER OF ENDOGENOUS PROGESTERONE IS UNUSUALLY RAPID, T/2 IN BLOOD BEING FEW MIN, & DOUBTLESS EXOGENOUS MATERIAL IS HANDLED IN SAME WAY. SMALL AMT...IS STORED IN BODY FAT... PRESUMABLY, ABSORPTION FROM INTESTINAL TRACT IS PROMPT, BUT COMPD IS RAPIDLY TRANSFORMED DURING PASSAGE THROUGH LIVER... /PROGESTERONE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1439
17alpha-hydroxy-progesterone has known human metabolites that include 17Beta-21-dihydroxyprogesterone.
17alpha-hydroxy-progesterone is a known human metabolite of progesterone.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
ADMIN OF ESTROGEN & PROGESTIN, AS CONTAINED IN COMBINATION OR SEQUENTIAL PREPN, COULD INTERFERE WITH FERTILITY IN ANY ONE OF SEVERAL WAYS. HOWEVER, IT IS CLEAR THAT, AS CURRENTLY USED, MIXTURE INHIBITS OVULATION. ...CONTINUED ACTION OF PROGESTERONE SERVES TO INHIBIT RELEASE OF LH. /PROGESTINS/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1443
IT ACTS AS ANTIGONADOTROPHIC AGENT ON ANTERIOR PITUITARY INHIBITING FSH RELEASE &, THUS, FOLLICULAR GROWTH, ESTROGEN PRODUCTION, & ESTRUS. IT ALSO INHIBITS LH RELEASE, THUS PREVENTING OVULATION, CORPORA LUTEA FORMATION, & FURTHER PROGESTERONE SECRETION. BY INHIBITING LH...HOLDS PROGESTERONE LEVELS IN CHECK.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 269
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