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2D Structure
Also known as: 7681-11-0, Thyro-block, Pima, Kali iodide, Potassium iodide (ki), Knollide
Molecular Formula
IK
Molecular Weight
166.0028  g/mol
InChI Key
NLKNQRATVPKPDG-UHFFFAOYSA-M
FDA UNII
1C4QK22F9J

An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
potassium;iodide
2.1.2 InChI
InChI=1S/HI.K/h1H;/q;+1/p-1
2.1.3 InChI Key
NLKNQRATVPKPDG-UHFFFAOYSA-M
2.1.4 Canonical SMILES
[K+].[I-]
2.2 Other Identifiers
2.2.1 UNII
1C4QK22F9J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Antistrumin

2. Iodide, Potassium

3. Ioduro Potasico Rovi

4. Iosat

5. Jod Beta

6. Jodetten Henning

7. Jodgamma

8. Jodid

9. Jodid Dura

10. Jodid Hexal

11. Jodid Ratiopharm

12. Jodid Verla

13. Jodid-ratiopharm

14. Mono Jod

15. Mono-jod

16. Pima

17. Sski

18. Thyro Block

19. Thyro-block

20. Thyroprotect

2.3.2 Depositor-Supplied Synonyms

1. 7681-11-0

2. Thyro-block

3. Pima

4. Kali Iodide

5. Potassium Iodide (ki)

6. Knollide

7. Thyroshield

8. Iosat

9. Kisol

10. Kalii Iodidum

11. Potassium;iodide

12. Asmofug E

13. Potassium Diiodide

14. Dipotassium Diiodide

15. Potassium Monoiodide

16. Potassiumiodide

17. Kaliumiodid

18. Thyrosafe

19. Potassium Iodide (k2i2)

20. Potassium Iodide (k(i2))

21. K1-n

22. Kali Iodatum

23. Potassium-iodide

24. Mfcd00011405

25. Nsc-77362

26. 1c4qk22f9j

27. Chebi:8346

28. Joptone

29. Potide

30. Potassium Iodide Solution

31. Iodure De Potassium

32. Tripotassium Triiodide

33. Caswell No. 694

34. Iodopotassium

35. Kalium Iodatum

36. Potassium Iodide [jan]

37. Iodine Solution, 0.1n (n/10)

38. Potassium Iodide (k3i3)

39. Hsdb 5040

40. Einecs 231-659-4

41. Nsc 77362

42. Epa Pesticide Chemical Code 075701

43. Unii-1c4qk22f9j

44. Potasium Iodide

45. Potassium Iodid

46. Potassium Iodide [usp:jan]

47. Ai3-52931

48. Ccris 8168

49. Potassium Salt Of Hydriodic Acid

50. Thyroblock (tn)

51. Potassium Iodide Ts

52. Gold Etchant, Standard

53. Iodine (as Potassium)

54. Potassium Iodide,(s)

55. Nesslers Reagent Solution

56. Potassium Iodide Usp/fcc

57. Potassium Iodide Acs Grade

58. Wln: Ka I

59. Ec 231-659-4

60. Potassium Iodide, Ultra Dry

61. Potassium Iodide, 99.5%

62. Chembl1141

63. Dsstox_cid_14836

64. Dsstox_rid_79208

65. Kali Iodatum [hpus]

66. Dsstox_gsid_34836

67. Iodine (as Potassium Iodide)

68. Potassium Iodide Neutral Acs

69. Potassium Iodide [mi]

70. Potassium Iodide, Acs Reagent

71. Potassium Iodide [fcc]

72. Potassium Iodide (jp17/usp)

73. Potassium Iodide [hsdb]

74. Potassium Iodide [inci]

75. Dtxsid7034836

76. Potassium Iodide [vandf]

77. Potassium Iodide [mart.]

78. Potassium Iodide, Lr, >=99%

79. Potassium Iodide [usp-rs]

80. Potassium Iodide [who-dd]

81. Potassium Iodide [who-ip]

82. Hms3651g04

83. Cs-b1801

84. K I (h2 O)2

85. Nsc77362

86. Potassium Iodide, Ar, >=99.8%

87. Tox21_301293

88. S1897

89. Kalii Iodidum [who-ip Latin]

90. Mercuric And Potassium Iodide Solution

91. Akos015833375

92. Potassium Iodide [orange Book]

93. Ccg-266323

94. Db06715

95. Iodine (as Potassium) [vandf]

96. Potassium Iodide [ep Monograph]

97. Potassium Iodide, Bioxtra, >=99.0%

98. Potassium Iodide [usp Monograph]

99. Ncgc00257542-01

100. Potassium Iodide Solution, 15 % (w/v)

101. Potassium Iodide, Reagentplus(r), 99%

102. Cas-7681-11-0

103. Potassium Iodide, Vetec(tm) Reagent Grade

104. Potassium Iodide, Acs Reagent, >=99.0%

105. Potassium Iodide, Plant Cell Culture Tested

106. Ft-0645116

107. P1721

108. Potassium Iodide, 99.999% (metals Basis)

109. Sw219147-1

110. Iodine (as Potassium Iodide) [vandf]

111. Potassium Iodide, Bioultra, >=99.5% (at)

112. Potassium Iodide, Tested According To Ph.eur.

113. Potassium Iodide, Trace Metals Grade 99.99%

114. C08219

115. D01016

116. Potassium Iodide, Saj First Grade, >=99.5%

117. Ab01274864-01

118. Ab01568251_01

119. Potassium Iodide, >=99.99% Trace Metals Basis

120. Potassium Iodide, Jis Special Grade, >=99.5%

121. Potassium Iodide, Purum P.a., >=99.0% (at)

122. Q121874

123. Potassium Iodide, Puriss. P.a., Acs Reagent, >=99.0% (at)

124. Potassium Iodide, Suitable For Oxidant Determination, >=99.5%

125. Potassium Iodide, Anhydrous, Beads, -10 Mesh, 99.998% Trace Metals Basis

126. Potassium Iodide, Puriss. P.a., Reag. Iso, Reag. Ph. Eur., >=99.5%

127. Potassium Iodide, United States Pharmacopeia (usp) Reference Standard

128. Potassium Iodide, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99%

129. Potassium Iodide, Anhydrous, Free-flowing, Redi-dri(tm), Reagentplus(r), 99%

130. Potassium Iodide, Pharmaceutical Secondary Standard; Certified Reference Material

131. Potassium Iodide, Puriss., Meets Analytical Specification Of Ph.??eur. Bp, Usp, 99.0-100.5% (calc. To The Dried Substance)

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 166.0028 g/mol
Molecular Formula IK
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area0
Heavy Atom Count2
Formal Charge0
Complexity2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

Potassium iodide is indicated as a radiation protectant (thyroid gland) prior to and following oral administration or inhalation of radioactive isotopes of iodine or in radiation emergencies. /Included in US product labeling/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Potassium iodide is indicated in the treatment of hyperthyroidism. /Included in US product labeling/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Potassium iodide is used in the treatment of erythema nodosum. /NOT included in US product labeling/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Potassium iodide is used concurrently with an antithyroid agent to induce thyroid involution prior to thyroidectomy. /NOT included in US product labeling/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


For more Therapeutic Uses (Complete) data for POTASSIUM IODIDE (12 total), please visit the HSDB record page.


4.2 Drug Warning

VET: WARNING: Iodism may occur at therapeutic doses.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 475


Since some individuals are markedly sensitive to iodides, potassium iodide should be used with caution when initially administered. Patients at risk for iodine-induced adverse effects include those with hypocomplementemic vasculitis and those with goiter or autoimmune thyroid disease.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 3125


... Potassium iodide should be used with extreme caution, if at all, in patients with tuberculosis and is contraindicated in the presents of acute bronchitis.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 3125


Potassium iodide may cause salivary gland swelling or tenderness, burning of mouth or throat, metallic taste, soreness of teeth and gums, and unusual increase in salivation.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


For more Drug Warnings (Complete) data for POTASSIUM IODIDE (22 total), please visit the HSDB record page.


4.3 Drug Indication

Potassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.


5 Pharmacology and Biochemistry
5.1 ATC Code

R - Respiratory system

R05 - Cough and cold preparations

R05C - Expectorants, excl. combinations with cough suppressants

R05CA - Expectorants

R05CA02 - Potassium iodide


S - Sensory organs

S01 - Ophthalmologicals

S01X - Other ophthalmologicals

S01XA - Other ophthalmologicals

S01XA04 - Potassium iodide


V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AB - Antidotes

V03AB21 - Potassium iodide


5.2 Absorption, Distribution and Excretion

Although eliminated chiefly by the kidneys, it can also be found in saliva, tears, sweat, & milk. ... Some of retained iodine is stored in the thyroid & incorporated into thyroxine.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 475


The iodide ion is excreted in part by bronchi.

American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 48:00


Potassium iodide is distributed into /human/ breast milk ...

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


5.3 Mechanism of Action

In hyperthyroid patients, potassium iodide produces rapid remission of symptoms by inhibiting the release of thyroid hormone into the circulation. The effects of potassium iodide on the thyroid gland include reduction of vascularity, a firming of the glandular tissue, shrinkage of the size of individual cells, reaccumulation of colloid in the follicles, and increases in bound iodine. These actions may facilitate thyroidectomy when the medication is given prior to surgery.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


When administered prior to and following administration of radioactive isotopes and in radiation emergencies involving the release of radioactive iodine, potassium iodide protects the thyroid gland by blocking the thyroidal uptake of radioactive isotopes of iodine.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


The mechanism of action of potassium iodide's antifungal activity against Sporothix schenckii has not been determined. Potassium iodide does not appear to increase monocyte or neutrophil killing of S. schenckii in in vitro studies. However, exposure of the yeast form of S. schenckii to various concentrations of iodine (iodine and potassium iodide solution) has resulted in rapid cell destruction.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 3126


Potassium iodide is thought to act as an expectorant by increasing respiratory tract secretions and thereby decreasing the viscosity of mucous ...

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 3126


When potassium iodide is administered simultaneously with radiation exposure, the protectant effect is approximately 97%. Potassium iodide given 12 and 24 hours before exposure yields a 90% and 70% protectant effect, respectively. However, potassium iodide administered 1 and 3 hours after exposure results in an 85% and 50% protectant effect, respectively. Potassium iodide administered more than 6 hours after exposure is thought to have a negligible protectant effect.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.