loader
Please Wait
Applying Filters...
menu
    • menu

    Technical details about CAS 78287-27-1, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

    Virtual Booth

    Contact Supplier

    Bora Pharmaceuticals- Making success more certain.

    Virtual Booth

    Contact Supplier

    Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

    Virtual Booth

    Contact Supplier

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    Virtual Booth

    Contact Supplier

    Axplora- The partner of choice for complex APIs.

    Virtual Booth

    Contact Supplier

    Fareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

    Virtual Booth

    Contact Supplier

    Menu

    CAS 78287-27-1

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 78287-27-1, 7-ethyl camptothecin, (s)-4,11-diethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 7-ethyl-20(s)-camptothecin, Lpy7fe51iw, (19s)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
    Molecular Formula
    C22H20N2O4
    Molecular Weight
    376.4  g/mol
    InChI Key
    MYQKIWCVEPUPIL-QFIPXVFZSA-N
    FDA UNII
    LPY7FE51IW
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (19S)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
    2.1.2 InChI
    InChI=1S/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1
    2.1.3 InChI Key
    MYQKIWCVEPUPIL-QFIPXVFZSA-N
    2.1.4 Canonical SMILES
    CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=CC=CC=C51
    2.1.5 Isomeric SMILES
    CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=CC=CC=C51
    2.2 Other Identifiers
    2.2.1 UNII
    LPY7FE51IW
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 78287-27-1

    2. 7-ethyl Camptothecin

    3. (s)-4,11-diethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

    4. 7-ethyl-20(s)-camptothecin

    5. Lpy7fe51iw

    6. (19s)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

    7. (s)-4,11-diethyl-4-hydroxy-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione

    8. (19s)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

    9. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4-hydroxy-, (s)-

    10. Mfcd06657922

    11. 7-ethyl-camptothecin

    12. (4s)-4,11-diethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

    13. Unii-lpy7fe51iw

    14. Schembl1005149

    15. 7-ethylcamptothecin, Aldrichcpr

    16. Dtxsid60228960

    17. Chebi:191009

    18. Myqkiwcvepupil-qfipxvfzsa-n

    19. Amy24894

    20. Hy-n2108

    21. Bdbm50092821

    22. S5111

    23. Akos015909654

    24. Ac-1267

    25. Ccg-268367

    26. Cs-o-30626

    27. Ks-5291

    28. Pd088243

    29. 7-ethylcamptothecin [usp Impurity]

    30. Cs-0018629

    31. E0781

    32. H11443

    33. A865061

    34. J-502459

    35. (19s)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0?,??.0?,?.0??,??]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

    36. (r)-4-ethyl-4-methyl-1,4a,12,13a-tetrahydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

    37. (s)-4,11-diethyl-4,9-dihydroxy-1,5,5a,12-tetrahydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

    38. (s)-4,11-diethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

    39. (s)-4,11-diethyl-4-hydroxy-1h-pyrano(3,4:6,7)indolizino(1,2-b)quin Oline-3,14(4h,12h)-dione

    40. (s)-4,11-diethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione (7-ethyl-20(s)-camptothecin)

    41. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4-hydroxy-, (4s)-

    42. 4,11-diethyl-4,9-dihydroxy-(4s)-3,4,12,14-tetrahydro-1h-pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-3,14-dione

    43. 4,11-diethyl-4,9-dihydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

    44. 4,11-diethyl-4,9-dihydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (sn-38)

    45. 4,11-diethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 376.4 g/mol
    Molecular Formula C22H20N2O4
    XLogP31.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area79.7
    Heavy Atom Count28
    Formal Charge0
    Complexity787
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1