1. Bbpht
2. Butyl Benzyl Phthalate
3. Butylbenzyl Phthalate
1. Butyl Benzyl Phthalate
2. 85-68-7
3. Sicol
4. Palatinol Bb
5. Santicizer 160
6. Butylbenzyl Phthalate
7. Unimoll Bb
8. Benzyl N-butyl Phthalate
9. N-butyl Benzyl Phthalate
10. Sicol 160
11. 1,2-benzenedicarboxylic Acid, Butyl Phenylmethyl Ester
12. Butylbenzylphthalate
13. Phthalic Acid, Benzyl Butyl Ester
14. Bbp
15. Phthalic Acid Benzyl Butyl Ester
16. Nci-c54375
17. 2-o-benzyl 1-o-butyl Benzene-1,2-dicarboxylate
18. Nsc 71001
19. Butyl Phenylmethyl 1,2-benzenedicarboxylate
20. Benzyl-butylester Kyseliny Ftalove
21. Ypc4pjx59m
22. Benzyl Butyl Benzene-1,2-dicarboxylate
23. Dtxsid3020205
24. 1,2-benzenedicarboxylic Acid, 1-butyl 2-(phenylmethyl) Ester
25. Chebi:34595
26. Nsc-71001
27. Ncgc00090780-04
28. Dsstox_cid_205
29. Dsstox_rid_75431
30. Dsstox_gsid_20205
31. Benzyl Butylphthalate
32. Phthalic Acid, Benzylbutyl Ester
33. Caswell No. 125g
34. Cas-85-68-7
35. Ketjenflex 160
36. Ccris 104
37. Benzyl Butyl Phthalate, Analytical Standard
38. Diacizer D 160
39. Santicizer S 160
40. Hsdb 2107
41. Einecs 201-622-7
42. Unii-ypc4pjx59m
43. Brn 2062204
44. Benzyl-butylester Kyseliny Ftalove [czech]
45. Ai3-14777
46. Benzylbutylphthalate
47. Mfcd00009440
48. Benzyl-butyl-phthalate
49. Benzyl Butyl Phthalated
50. Spectrum_001977
51. 4mg6
52. Benyl N-butyl Phthalate
53. Butyl Phenylmethyl Ester
54. Specplus_000622
55. Spectrum2_001805
56. Spectrum3_000871
57. Spectrum4_000711
58. Spectrum5_002070
59. Wln: Qvr Bvo1r
60. Phthalic Acid Benzyl Butyl
61. Ec 201-622-7
62. O2-benzyl O1-butyl Benzene-1,2-dicarboxylate
63. 1, Butyl Phenylmethyl Ester
64. Bbp, Benzyl Butyl Phthalate
65. Schembl49678
66. Bspbio_002541
67. Kbiogr_001261
68. Kbioss_002543
69. Mls002177799
70. Benzyl Butyl Phthalate, 98%
71. Bidd:er0643
72. Divk1c_006718
73. Spbio_001789
74. 1-benzyl 2-butyl Phthalate #
75. Chembl1450327
76. Kbio1_001662
77. Kbio2_002534
78. Kbio2_005102
79. Kbio2_007670
80. Kbio3_002041
81. Hms3039o09
82. Phthalic Acid Benzyl N-butyl Ester
83. Nsc71001
84. Zinc1696593
85. Tox21_202991
86. Tox21_400057
87. Ccg-39615
88. S5822
89. Butyl Benzyl Phthalate [hsdb]
90. Butyl Benzyl Phthalate [iarc]
91. Butyl Benzyl Phthalate [inci]
92. Akos015839717
93. Phthalic Acid Benzyl Ester Butyl Ester
94. Cs-w012054
95. Hy-w011338
96. Ncgc00090780-01
97. Ncgc00090780-02
98. Ncgc00090780-03
99. Ncgc00090780-05
100. Ncgc00260536-01
101. Smr001261796
102. 1-benzyl 2-butyl Benzene-1,2-dicarboxylate
103. Ft-0655622
104. Ft-0662711
105. P0288
106. Q414809
107. Q-101286
108. Brd-k34359596-001-02-1
109. Phthalic Acid, Benzylbutyl Ester 100 Microg/ml In Acetonitrile
110. Phthalic Acid, Benzylbutyl Ester 1000 Microg/ml In Cyclohexane
111. Benzyl Butyl Phthalate, Certified Reference Material, Tracecert(r)
112. 27g
| Molecular Weight | 312.4 g/mol |
|---|---|
| Molecular Formula | C19H20O4 |
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 312.13615911 g/mol |
| Monoisotopic Mass | 312.13615911 g/mol |
| Topological Polar Surface Area | 52.6 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 374 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Teratogens
An agent that causes the production of physical defects in the developing embryo. (See all compounds classified as Teratogens.)
This study examined the extent of dermal absorption of a series of phthalate diesters in the rat. Those tested were dimethyl, diethyl, dibutyl, diisobutyl, dihexyl, di(2-ethylhexyl), diisodecyl, and benzyl butyl phthalate. Hair from a skin area (1.3 cm in diameter) on the back of male F344 rats was clipped, the 14C-phthalate diester was applied in a dose of 157 umol/kg, and the area of application was covered with a perforated cap. The rat was restrained and housed for 7 days in a metabolic cage that allowed separate collection of urine and feces. Urine and feces were collected every 24 hr, and the amount of carbon-14 excreted was taken as an index of the percutaneous absorption. At 24 hr, diethyl phthalate showed the greatest excretion (26%). As the length of the alkyl side chain increased, the amount of carbon-14 excreted in the first 24 hr decreased significantly. The cumulative percentage dose excreted in 7 days was greatest for diethyl, dibutyl, and diisobutyl phthalate, about 50-60% of the applied 14C; and intermediate (20-40%) for dimethyl, benzyl butyl, and dihexyl phthalate. Urine was the major route of excretion of all phthalate diesters except for diisodecyl phthalate. This compound was poorly absorbed and showed almost no urinary excretion. After 7 days, the percentage dose for each phthalate that remained in the body was minimal and showed no specific tissue distribution. Most of the unexcreted dose remained in the area of application. These data show that the structure of the phthalate diester determines the degree of dermal absorption. Absorption maximized with diethyl phthalate and then decreased significantly as the alkyl side chain length increased.
PMID:2925020 Elsisi AE et al; Fundam Appl Toxicol 12(1): 70-7 (1989)
... Male Fischer-344 rats were dosed with (14)C-labeled butyl benzyl phthalate (BBP) at 2, 20, 200, or 2000 mg/kg orally or 20 mg/kg iv to detect the effects of dose on rates and routes of excretion. In 24 hr, 61-74% of the dose was excreted in the urine and 13-19% in the feces at 2-200 mg/kg. At 2000-mg/kg, 16% of the (14)C was excreted in the urine and 57% in the feces. Urinary (14)C was composed of monophthalate glucuronides derivatives (MP: 10-42% of the dose) and monophthalate glucuronides (2-21% of the dose). At 4 hr after iv administration of BBP (20 mg/kg), 53-58% of the dose was excreted in the bile of anesthetized rats. BBP was not found in the bile, but monobutyl glucuronide and monobenzyl phthalate glucuronide (26 and 13% of the dose, respectively) and trace amts of free monoesters (2% of the dose) and unidentified metabolites (14% of the dose) were present. ... The half-lives of BBP, MP, and total (14)C in blood (20 mg/kg, iv) were 10 min, 5.9 hr, and 6.3 hr, respectively. ...
PMID:3959124 Eigenberg DA et al; J Toxicol Environ Health 17 (4): 445-56 (1986)
Following intravenous administration of 20 mg/kg of (14)C-BBP, 55% of the dose was excreted into bile and 34% was excreted into the urine.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V6 869
Beagle dogs were given a 5 g/kg bw oral dose of butyl benzyl phthalate divided over a 4 hr period. Unchanged butyl benzyl phthalate in the feces comprised 88-91% of the dose. While butyl benzyl phthalate was not present in the urine, some 4.2% of the dose was present as phthalic acid
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 119 (1999)
For more Absorption, Distribution and Excretion (Complete) data for BUTYL BENZYL PHTHALATE (8 total), please visit the HSDB record page.
BBP was not found in the bile, but monobutyl glucuronide and monobenzyl phthalate glucuronide (26 and 13% of the dose, respectively) and trace amounts of free monoesters (2% of the dose) and unidentified metabolites (14% of the dose) were present. Although BBP is an asymetrical diester with the potential of forming equal amounts of monobutyl phthalate and monobenzyl phthalate, larger quantities of monobutyl phthalate were formed (monobutyl phthalate= 44% vs monobenzyl phthalate= 16% of the dose). ...
PMID:3959124 Eigenberg DA et al; J Toxicol Environ Health 17 (4): 445-56 (1986)
The urinary monoester metabolites of seven commonly used phthalates /were measured/ in approximately 2,540 samples collected from participants of the National Health and Nutrition Examination Survey (NHANES), 1999-2000, who were greater than or equal to 6 years of age. ... Detectable levels of metabolites monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), and mono-(2-ethylhexyl) phthalate (MEHP) /were found/ in > 75% of the samples, suggesting widespread exposure in the United States to diethyl phthalate, dibutyl phthalate or diisobutylphthalate, benzylbutyl phthalate, and di-(2-ethylhexyl) phthalate, respectively. ... Monoisononyl phthalate, mono-cyclohexyl phthalate, and mono-n-octyl phthalate /were detected infrequently/, suggesting that human exposures to di-isononyl phthalate, dioctylphthalate, and dicyclohexyl phthalate, respectively, are lower than those listed above, or the pathways, routes of exposure, or pharmacokinetic factors such as absorption, distribution, metabolism, and elimination are different. Non-Hispanic blacks had significantly higher concentrations of MEP than did Mexican Americans and non-Hispanic whites. Compared with adolescents and adults, children had significantly higher levels of MBP, MBzP, and MEHP but had significantly lower concentrations of MEP. Females had significantly higher concentrations of MEP and MBzP than did males, but similar MEHP levels. Of particular interest, females of all ages had significantly higher concentrations of the reproductive toxicant MBP than did males of all ages; however, women of reproductive age (i.e., 20-39 years of age) had concentrations similar to adolescent girls and women 40 years of age...
PMID:14998749 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241863 Silva MJ et al; Environ Health Perspect 112 (3): 331-8 (2004); Erratum in: Environ Health Perspect 112 (5): A270 (2004).
Three groups of eight volunteers were administered stable isotope-labelled ... benzylbutylphthalate. ... For benzylbutylphthalate, 67% and 78% was eliminated as monobenzylphthalate and only 6% (measured for the high dose only) was eliminated as monobutylphthalate. ...
PMID:11761117 Anderson WA et al; Food Addit Contam 18 (12): 1068-74 (2001)
n-Butyl benzyl phthalate (BBP) ... has been orally administered to female Wistar rats with four doses (150, 475, 780 and 1500 mg/kg body weight/day) for 3 consecutive days. Metabolites recovered in urine were analyzed by gas chromatography-mass spectrometry (GC-MS) after 24, 48 and 72 hours. Six metabolites were identified. Mono-n-butyl phthalate (MBuP) and mono-n-benzyl phthalate (MBeP) represented respectively 29-34% and 7-12% of the total recovered metabolites. Hippuric acid, the main metabolite of benzoic acid, represented the second major metabolite (51-56%). Phthalic acid, benzoic acid and an omega-oxidized metabolite of MBuP were also recovered in urine but in small quantities. BBP was never identified in urine. Total urinary metabolites recovery represented 56% of the dose administered in the first 24 hours. However, total recovery decreased when the dose increases (43% at 780 mg/kg body weight/day, only 30% at 1500 mg/kg body weight/day). Whatever the time was, BBP metabolites recovered in urine were all present and in the same proportions for the two lowest doses. Discrepancy in metabolites quantities expressed as percentages of the dose observed in urine of rat treated with the highest BBP dose disappeared with time as MBuP, MBeP and hippuric acid recovery has significantly increased at day 3. ...
PMID:10506015 Nativelle C et al; Food Chem Toxicol 37 (8): 905-17 (1999)
For more Metabolism/Metabolites (Complete) data for BUTYL BENZYL PHTHALATE (9 total), please visit the HSDB record page.
The half-lives of butyl benzyl phthalate (BBP), monophthalate (MP), and total (14)C in blood (20 ng/kg, intravenously) were 10 min, 5.9 hr, and 6.3 hr, respectively.
PMID:3959124 Eigenberg DA et al; J Toxicol Environ Health 17 (4): 445-56 (1986)
The half-life of BBP in blood is 10 min following an oral administration of 5 g/kg to dogs.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V6 869
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