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2D Structure
Also known as: 57470-78-7, Celiprolol hcl, Selectol, Celiprolol (hydrochloride), Celiprolol hydrochloride [usan], Celectol
Molecular Formula
C20H34ClN3O4
Molecular Weight
416.0  g/mol
InChI Key
VKJHTUVLJYWAEY-UHFFFAOYSA-N
FDA UNII
G1M3398594

A cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea;hydrochloride
2.1.2 InChI
InChI=1S/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H
2.1.3 InChI Key
VKJHTUVLJYWAEY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)C(=O)NC1=CC(=C(C=C1)OCC(CNC(C)(C)C)O)C(=O)C.Cl
2.2 Other Identifiers
2.2.1 UNII
G1M3398594
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Celiprolol

2. Celiprolol Monohydrochloride

3. Celiprolol, (+,-)-isomer

4. Celiprolol, (r)-isomer

5. Celiprolol, (s)-isomer

6. Celiprolol, Monohydrochloride, (r)-isomer

7. Celiprolol, Monohydrochloride, (s)-isomer

8. Hydrochloride, Celiprolol

9. Monohydrochloride, Celiprolol

10. N'-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-n,n-diethylurea

11. Rev 5320a

12. Rev-5320a

13. Rev5320a

14. Selectol

15. St 1396

16. St-1396

17. St1396

2.3.2 Depositor-Supplied Synonyms

1. 57470-78-7

2. Celiprolol Hcl

3. Selectol

4. Celiprolol (hydrochloride)

5. Celiprolol Hydrochloride [usan]

6. Celectol

7. Nsc-324509

8. 3-(3-acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea Hydrochloride

9. 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea;hydrochloride

10. Selectrol

11. G1m3398594

12. Dsstox_cid_26850

13. Dsstox_rid_81959

14. Dsstox_gsid_46850

15. Selecor

16. St 1396

17. Selectol (tn)

18. Cas-57470-78-7

19. Ccris 1095

20. Celiprolol Clorhidrato

21. Celiprololhydrochloride

22. Celiprolol Clorhidrato [spanish]

23. Celiprolol Hydrochlorid

24. Celiprolol Hydrochlorid [german]

25. St-1396

26. Clorhidrato De Celiprolol

27. Clorhidrato De Celiprolol [spanish]

28. Einecs 260-752-2

29. Cordiax

30. Unii-g1m3398594

31. Nsc 324509

32. Celipolol Hydrochloride

33. Ncgc00181108-01

34. 3-(3-acetil-4-(3-tert-butilamino-2-hidroxipropoxi)fenil)-1,1-dietilurea Hcl [spanish]

35. 3-(3-acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea Monohydrochloride

36. 3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylharnstoff Hcl [german]

37. 3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylurea Hydrochloride

38. Celipolol Hydrochloride,(s)

39. Acer002

40. Schembl349227

41. Acer-002

42. Chembl1742424

43. Dtxsid0046850

44. Chebi:31385

45. Bcp13692

46. Hy-b1264

47. Tox21_112722

48. Celiprolol Hydrochloride (jan/usan)

49. Celiprolol Hydrochloride [mi]

50. Mfcd00941500

51. Nsc324509

52. S5923

53. Celiprolol Hydrochloride [jan]

54. 3-(3-acetil-4-(3-tert-butilamino-2-hidroxipropoxi)fenil)-1,1-dietilurea Hcl

55. Akos015962014

56. Tox21_112722_1

57. Ccg-220599

58. 3-(3-acetyl-4-(3-((tert-butyl)amino)-2-hydroxypropoxy)phenyl)-1,1-diethyluronium Chloride

59. 3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylharnstoff Hcl

60. Celiprolol Hydrochloride [mart.]

61. Celiprolol Hydrochloride [who-dd]

62. Ncgc00344562-01

63. Ac-15451

64. Urea, 3-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-1,1-diethyl-, Monohydrochloride

65. Urea, N'-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-n,n-diethyl-, Monohydrochloride

66. Cs-0013049

67. Ft-0623541

68. Ft-0664448

69. Ft-0664449

70. Ft-0664450

71. Celiprolol Hydrochloride [ep Monograph]

72. D01741

73. F16785

74. 470c787

75. Sr-01000872714

76. Sr-01000872714-1

77. Q27278610

78. Celiprolol Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

79. 1-{3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-3,3-diethylurea Hydrochloride

80. 3-[3-acetyl-4-(3-tert-butylamino-2-hydroxy-propoxy)-phenyl]-1,1-diethyl-urea Hydrochloride

81. 3-(3-acetyl-4-((3-tert-butylamino)-2-hydroxypropoxy)-phenyl)-1,1-diethylurea Hydrochloride

82. Urea, N'-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxyphenyl)-n,n-diethyl-, Monohydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 416.0 g/mol
Molecular Formula C20H34ClN3O4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass415.2237843 g/mol
Monoisotopic Mass415.2237843 g/mol
Topological Polar Surface Area90.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity474
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)