1. Acid, Chenic
2. Acid, Chenique
3. Acid, Chenodeoxycholic
4. Acid, Gallodesoxycholic
5. Chenic Acid
6. Chenique Acid
7. Chenix
8. Chenodeoxycholate
9. Chenodeoxycholate, Sodium
10. Chenodiol
11. Chenofalk
12. Chenophalk
13. Gallodesoxycholic Acid
14. Henohol
15. Quenobilan
16. Quenocol
17. Sodium Chenodeoxycholate
1. Chenodiol
2. 474-25-9
3. Chenix
4. Chenic Acid
5. Cdca
6. Chenodeoxycholate
7. Chenodesoxycholic Acid
8. Gallodesoxycholic Acid
9. Chendol
10. Anthropodeoxycholic Acid
11. Anthropodesoxycholic Acid
12. Chenofalk
13. Anthropododesoxycholic Acid
14. Chenodesoxycholsaeure
15. Chenodiol [usan]
16. Chenocol
17. Chenossil
18. Cholanorm
19. Fluibil
20. Xenbilox
21. Chenocholic Acid
22. 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic Acid
23. Acido Chenodeoxicholico
24. 3alpha,7alpha-dihydroxy-5beta-cholanic Acid
25. Chenodesoxycholsaeure [german]
26. Acide Chenodeoxycholique
27. 7-alpha-hydroxylithocholic Acid
28. Acidum Chenodeoxycholicum
29. 7alpha-hydroxylithocholic Acid
30. Acide Chenodeoxycholique [inn-french]
31. Acido Chenodeoxicholico [inn-spanish]
32. Acidum Chenodeoxycholicum [inn-latin]
33. 3-alpha,7-alpha-dihydroxycholanic Acid
34. 3-alpha,7-alpha-dihydroxycholansaeure [german]
35. (4r)-4-[(3r,5s,7r,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoic Acid
36. 3-alpha,7-alpha-dihydroxycholansaeure
37. 0gei24lg0j
38. Chenodeoxycholic Acid [inn]
39. 3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oic Acid
40. Chebi:16755
41. Cholan-24-oic Acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)-
42. Chenodiol (usan)
43. Cholan-24-oic Acid, 3,7-dihydroxy-, (3a,5b,7a)-
44. Nsc-657949
45. Nsc-757798
46. (3alpha,5beta,7alpha)-3,7-dihydroxycholan-24-oic Acid
47. 5-beta-cholan-24-oic Acid, 3-alpha,7-alpha-dihydroxy-
48. (3alpha,5beta,7alpha,8xi)-3,7-dihydroxycholan-24-oic Acid
49. Henohol
50. Chenique Acid
51. Cholan-24-oic Acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)-
52. Dsstox_cid_260
53. Dsstox_rid_75469
54. Dsstox_gsid_20260
55. 3.alpha.,7.alpha.-dihydroxy-5.beta.-cholan-24-oic Acid
56. (4r)-4-[(1s,2s,5r,7s,9r,10r,11s,14r,15r)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic Acid
57. Chendeoxycholic Acid
58. Ccris 2195
59. Einecs 207-481-8
60. Unii-0gei24lg0j
61. Nsc 657949
62. Chenocedon
63. Chendal
64. Chenodex
65. Chenorm
66. Hekbilin
67. Kebilis
68. Mfcd00064142
69. Nsc657949
70. Ncgc00016387-02
71. (r)-4-((3r,5s,7r,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic Acid
72. Cas-474-25-9
73. Jn3
74. Chenodeoxycholic-acid
75. (+)-chenodeoxycholate
76. Chenodiol [mi]
77. Prestwick0_000285
78. Prestwick1_000285
79. Prestwick2_000285
80. Prestwick3_000285
81. Spectrum5_002009
82. Chenix (tn)
83. Chenodiol [vandf]
84. (+)-chenodeoxycholic Acid
85. Bmse000908
86. 7a-hydroxy-desoxycholsaeure
87. Ec 207-481-8
88. Bidd:pxr0056
89. Schembl25055
90. Bspbio_000190
91. Gtpl608
92. Mls002154253
93. 3a,7a-dihydroxy-5b-cholanate
94. Spbio_002409
95. 3,7-dihydroxy-5-cholanicacid
96. Bpbio1_000210
97. Chembl240597
98. Chenodeoxycholic Acid, >=97%
99. Chenodiol [orange Book]
100. Dtxsid2020260
101. 7.alpha.-hydroxylithocholic Acid
102. Bdbm21674
103. Chenodeoxycholic Acid, Free Acid
104. 3a,7a-dihydroxy-5b-cholanic Acid
105. Hms1568j12
106. Hms2095j12
107. Hms2234i22
108. Hms3712j12
109. Chenodeoxycholic Acid (jp16/inn)
110. Chenodeoxycholic Acid (jp17/inn)
111. Chenodeoxycholic Acid [jan]
112. Zinc3914808
113. Tox21_110412
114. Tox21_200491
115. (3beta,7beta,8xi,9xi,14xi,17alpha)-3,7-dihydroxycholan-24-oic Acid
116. 3a,7a-dihydroxy-5b-cholan-24-oate
117. Cholan-24-oic Acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)-
118. Hsci1_000210
119. Lmst04010032
120. Chenodeoxycholic Acid [mart.]
121. Akos024280614
122. Chenodeoxycholic Acid [who-dd]
123. Ccg-220285
124. Cs-0834
125. Db06777
126. 5beta-cholanic Acid-3alpha,7alpha-diol
127. Smp1_000064
128. 3.alpha.,7.alpha.-dihydroxycholansaeure
129. 3a,7a-dihydroxy-5b,14a,17b-cholanate
130. 3a,7a-dihydroxy-5b-cholan-24-oic Acid
131. Ncgc00142400-03
132. Ncgc00142400-04
133. Ncgc00142400-08
134. Ncgc00258045-01
135. (4r)-4-((1s,2s,7s,11s,5r,9r,10r,14r,15r)-5,9-dihydroxy-2,15-dimethyltetracyclo [8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoic Acid
136. 24404-86-2
137. 3.alpha.,7.alpha.-dihydroxycholanic Acid
138. As-13636
139. Hy-76847
140. Smr000857194
141. Chenodeoxycholic Acid [ep Impurity]
142. Chenodeoxycholic Acid [ep Monograph]
143. 3a,7a-dihydroxy-5b,14a,17b-cholanic Acid
144. Ab00513822
145. S1843
146. (3a,5b,7a)-3,7-dihydroxy-cholan-24-oate
147. 3alpha, 7alpha-dihydroxy-5beta-cholanoic Acid
148. 3alpha, 7alpha,-dihydroxy-5beta-cholanic Acid
149. C-2900
150. C02528
151. D00163
152. (3a,5b,7a)-3,7-dihydroxy-cholan-24-oic Acid
153. Ab00513822-06
154. Ab00513822_07
155. A827222
156. Q419028
157. 3.alpha.,7.alpha.-dihydroxy-5.beta.-cholanic Acid
158. Dihydroxy-3.alpha.,7.alpha.(5.beta.)cholanic Acid
159. Leadiant (formerly Chenodeoxycholic Acid Sigma-tau)
160. (3
161. A,5
162. A,7
163. A)-3,7-dihydroxycholan-24-oic Acid
164. 3.alpha.,7.alpha.-dihydroxy-5.beta.-cholanoic Acid
165. Brd-k18135438-001-16-7
166. Ursodeoxycholic Acid Impurity A [ep Impurity]
167. 0dbbbc66-0cfa-4db9-97f4-5b1492756a02
168. Z1270387252
169. 5.beta.-cholan-24-oic Acid, 3.alpha.,7.alpha.-dihydroxy-
170. (3alpha,5alpha,7beta,8alpha,17alpha)-3,7-dihydroxycholan-24-oic Acid
171. 3,7-dihydroxycholan-24-oic Acid, (3.alpha.,5.beta.,7.alpha.)- #
172. Chenodeoxycholic Acid, 500 Mug/ml In Methanol, Certified Reference Material
173. Chenodeoxycholic Acid, European Pharmacopoeia (ep) Reference Standard
174. Cholan-24-oic Acid, 3,7-dihydroxy-, (3-.alpha., 5-.beta., 7-.alpha.)-
175. Cholan-24-oic Acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- (9ci)
176. Cholan-24-oic Acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)
177. (4r)-4-[(1s,2s,5r,7s,9r,10r,11s,14r,15r)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0?,?.0??,??]heptadecan-14-yl]pentanoic Acid
| Molecular Weight | 392.6 g/mol |
|---|---|
| Molecular Formula | C24H40O4 |
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 392.29265975 g/mol |
| Monoisotopic Mass | 392.29265975 g/mol |
| Topological Polar Surface Area | 77.8 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 605 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 2 | |
|---|---|
| Drug Name | Chenodiol |
| PubMed Health | Chenodiol (By mouth) |
| Drug Classes | Gastrointestinal Agent |
| Drug Label | Chenodiol is the non-proprietary name for chenodeoxycholic acid, a naturally occurring human bile acid. It is a bitter-tasting white powder consisting of crystalline and amorphous particles freely soluble in methanol, acetone and acetic acid and prac... |
| Active Ingredient | Chenodiol |
| Dosage Form | Tablet |
| Route | Oral |
| Strength | 250mg |
| Market Status | Prescription |
| Company | Nexgen Pharma |
| 2 of 2 | |
|---|---|
| Drug Name | Chenodiol |
| PubMed Health | Chenodiol (By mouth) |
| Drug Classes | Gastrointestinal Agent |
| Drug Label | Chenodiol is the non-proprietary name for chenodeoxycholic acid, a naturally occurring human bile acid. It is a bitter-tasting white powder consisting of crystalline and amorphous particles freely soluble in methanol, acetone and acetic acid and prac... |
| Active Ingredient | Chenodiol |
| Dosage Form | Tablet |
| Route | Oral |
| Strength | 250mg |
| Market Status | Prescription |
| Company | Nexgen Pharma |
Chenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.
FDA Label
Chenodeoxycholic acid is indicated for the treatment of inborn errors of primary bile acid synthesis due to sterol 27 hydroxylase deficiency (presenting as cerebrotendinous xanthomatosis (CTX)) in infants, children and adolescents aged 1 month to 18 years and adults.
It acts by reducing levels of cholesterol in the bile, helping gallstones that are made predominantly of cholesterol to dissolve. Chenodeoxycholic acid is ineffective with stones of a high calcium or bile acid content.
Cathartics
Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)
Gastrointestinal Agents
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)
A05AA01
A - Alimentary tract and metabolism
A05 - Bile and liver therapy
A05A - Bile therapy
A05AA - Bile acids and derivatives
A05AA01 - Chenodeoxycholic acid
Absorption
Chenodiol is well absorbed from the small intestine.
Route of Elimination
About 80% of its bacterial metabolite lithocholate is excreted in the feces.
Chenodiol is well absorbed from the small intestine and taken up by the liver where it is converted to its taurine and glycine conjugates and secreted in bile. At steady-state, an amount of chenodiol near the daily dose escapes to the colon and is converted by bacterial action to lithocholic acid. About 80% of the lithocholate is excreted in the feces; the remainder is absorbed and converted in the liver to its poorly absorbed sulfolithocholyl conjugates. During chenodiol therapy there is only a minor increase in biliary lithocholate, while fecal bile acids are increased three- to fourfold.
Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.
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