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    Chloramphenicol Sodium Succinate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 144Xls

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    2D Structure
    Also known as: 982-57-0, Chloramphenicol succinate sodium, Chloramphenicol monosuccinate sodium salt, Chloramphenicol succinate sodium, 872109hx6b, Protophenicol
    Molecular Formula
    C15H15Cl2N2NaO8
    Molecular Weight
    445.2  g/mol
    InChI Key
    RPLOPBHEZLFENN-HTMVYDOJSA-M
    FDA UNII
    872109HX6B
    Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity. Chloramphenicol sodium succinate reversibly binds to the 50S subunit of bacterial ribosomes, thereby interfering with peptidyl transferase activity in the elongation process of protein synthesis. As a result, this agent prevents bacterial cell growth.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate
    2.1.2 InChI
    InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1
    2.1.3 InChI Key
    RPLOPBHEZLFENN-HTMVYDOJSA-M
    2.1.4 Canonical SMILES
    C1=CC(=CC=C1C(C(COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
    2.1.5 Isomeric SMILES
    C1=CC(=CC=C1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    872109HX6B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Chloramphenicol Hemisuccinate

    2. Chloramphenicol Monosuccinate

    3. Chloramphenicol Succinate Sodium

    4. Levomycetin Succinate

    2.3.2 Depositor-Supplied Synonyms

    1. 982-57-0

    2. Chloramphenicol Succinate Sodium

    3. Chloramphenicol Monosuccinate Sodium Salt

    4. Chloramphenicol Succinate Sodium

    5. 872109hx6b

    6. Protophenicol

    7. Dsstox_cid_4747

    8. Dsstox_rid_77520

    9. Dsstox_gsid_24747

    10. Butanedioic Acid, Mono(2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) Ester, Monosodium Salt, (r-(r*,r*))-

    11. Sodium Chloramphenicol Succinate

    12. Chloramphenicol Sodium Monosuccinate

    13. Cas-982-57-0

    14. Sodium 4-((2r,3r)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoate

    15. Ccris 6204

    16. Chloramphenicol-sukzinat-natrium

    17. Ncgc00094619-04

    18. Chloramphenicol Sodium Succinate, D-

    19. Einecs 213-568-1

    20. Chloramphenicol-sukzinat-natrium [german]

    21. Unii-872109hx6b

    22. Sodium;4-[(2r,3r)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate

    23. Chloramphenicol Sodium Succinate [usp:ban:jan]

    24. Chloromycetin Succinate (tn)

    25. D-threo-(-)-2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide Alpha-(sodium Succinate)

    26. Schembl193134

    27. Chloramphenicoli Natrii Succinas

    28. Chembl1200729

    29. Dtxsid2024747

    30. Tox21_113484

    31. Akos016340429

    32. Tox21_113484_1

    33. Ccg-212521

    34. Ks-5158

    35. Ncgc00094619-06

    36. Acetamide, 2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, Alpha-ester With Sodium Succinate

    37. Butanedioic Acid, Mono(2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) Ester, Monosodium Salt, (r-(r(sup *),r(sup *)))(-)

    38. Chloramphenicol Sodium Succinate (jp17/usp)

    39. Chloramphenicol Sodium Succinate [jan]

    40. Chloramphenicol Sodium Succinate [vandf]

    41. D02185

    42. Chloramphenicol Sodium Succinate [mart.]

    43. Chloramphenicol Sodium Succinate [who-dd]

    44. Chloramphenicol Sodium Succinate [who-ip]

    45. W-100087

    46. Chloramphenicol Monosuccinate Sodium Salt [mi]

    47. Chloramphenicol Sodium Succinate [ep Monograph]

    48. Chloramphenicol Sodium Succinate [orange Book]

    49. Chloramphenicoli Natrii Succinas [who-ip Latin]

    50. Q27269783

    51. Chloramphenicol Sodium Succinate [usp Monograph]

    52. Butanedioic Acid, Mono((2r,3r)-2-((dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) Ester, Monosodium Salt

    53. D-threo-(-)-2,2-dichloro-n-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl)acetamide .alpha.-(sodium Succinate)

    54. Sodium4-((2r,3r)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 445.2 g/mol
    Molecular Formula C15H15Cl2N2NaO8
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count9
    Exact Mass444.0103151 g/mol
    Monoisotopic Mass444.0103151 g/mol
    Topological Polar Surface Area162 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity541
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameChloramphenicol sodium succinate
    Drug LabelIMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM SUCCINATE.CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE ONLY. IT HAS BEENDEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.1. Chloramphenicol sodium...
    Active IngredientChloramphenicol sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 1gm base/vial
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    2 of 2  
    Drug NameChloramphenicol sodium succinate
    Drug LabelIMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM SUCCINATE.CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE ONLY. IT HAS BEENDEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.1. Chloramphenicol sodium...
    Active IngredientChloramphenicol sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 1gm base/vial
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Amphenicols [EXT]; Amphenicol-class Antibacterial [EPC]