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    Chlorpheniramine Maleate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DRUG PRODUCT COMPOSITIONS

    RELATED EXCIPIENT COMPANIES

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    $ API Ref.Price (USD/KG) : 40Xls

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    2D Structure
    Also known as: 113-92-8, Chlorphenamine maleate, Neorestamin, Synistamin, Piriton, Chlor-trimeton
    Molecular Formula
    C20H23ClN2O4
    Molecular Weight
    390.9  g/mol
    InChI Key
    DBAKFASWICGISY-BTJKTKAUSA-N
    FDA UNII
    V1Q0O9OJ9Z
    A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    DBAKFASWICGISY-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    V1Q0O9OJ9Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aller-chlor

    2. Antihistaminico Llorens

    3. Chlo-amine

    4. Chlor-100

    5. Chlor-trimeton

    6. Chlor-tripolon

    7. Chlorphenamine

    8. Chlorpheniramine

    9. Chlorpheniramine Tannate

    10. Chlorpro

    11. Chlorprophenpyridamine

    12. Chlorspan 12

    13. Chlortab-4

    14. Cloro-trimeton

    15. Efidac 24

    16. Kloromin

    17. Maleate, Chlorpheniramine

    18. Piriton

    19. Tannate, Chlorpheniramine

    20. Teldrin

    2.3.2 Depositor-Supplied Synonyms

    1. 113-92-8

    2. Chlorphenamine Maleate

    3. Neorestamin

    4. Synistamin

    5. Piriton

    6. Chlor-trimeton

    7. Antagonate

    8. Kloromin

    9. Chlorphenamine Hydrogen Maleate

    10. Histaspan

    11. Pyridamal

    12. Efidac

    13. Chlorpheniramine (maleate)

    14. Nci-c55265

    15. Polaronil

    16. Chlorphenamine Maleates

    17. V1q0o9oj9z

    18. Chlorpheniramine Maleate Salt

    19. Chlorprophenpyridamine Maleate

    20. Chloropheniramine Maleate

    21. Chebi:3645

    22. 3-(4-chlorophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

    23. Nsc-756684

    24. Chlortrimeton

    25. Allerclor

    26. Allergin

    27. Chlormene

    28. Ibioton

    29. Lorphen

    30. Alunex

    31. Dehist

    32. Piriex

    33. Chlor-tripolon

    34. C-meton

    35. (z)-but-2-enedioic Acid;3-(4-chlorophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine

    36. Histadur Dura-tabs

    37. Chlor-trimeton Od

    38. Pyridamal 100

    39. Pyridamal-100

    40. Polaronil [german]

    41. Carbinoxamide Maleate

    42. Chlor-trimeton Allergy

    43. Phenalin

    44. Chlor-trimeton Injection

    45. Histaspan-plus

    46. Histaspan-d

    47. Medique Chlorphen

    48. Dl-chlorpheniramine Maleate

    49. Ru-tuss Capsules

    50. Smr000466271

    51. Chloroprophenpyridamine Maleate

    52. Ccris 1418

    53. 3-(4-chlorophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-aminium (2z)-3-carboxyprop-2-enoate

    54. Chlor-trimeton 12 Hour

    55. Efidac 24 Chlorpheniramine Maleate

    56. Sr-01000075261

    57. M.p. Chlorcaps T.d.

    58. Einecs 204-037-5

    59. Mfcd00069225

    60. Chlorpheniramine Maleate Oros Tablets

    61. Unii-v1q0o9oj9z

    62. Nasohist

    63. Puermin

    64. Corfen

    65. Lohist

    66. Chlor-trimeton Repetabs, Syrup, And Tablets

    67. Sine Off

    68. Sildec Pe

    69. Alka-seltzer Plus

    70. Prestwick_57

    71. Chlorphenaminemaleate

    72. Chlorpheniramine Maleate [usp:jan]

    73. Teldrin (tn)

    74. (+/-)-chlorpheniramine Maleate Salt

    75. Chlorophenaminemaleate

    76. Zodryl Ac 25

    77. Zodryl Ac 30

    78. Zodryl Ac 40

    79. Zodryl Ac 50

    80. Zodryl Ac 60

    81. Zodryl Ac 80

    82. Chlor-trimeton (tn)

    83. 1-p-chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane Maleate

    84. Dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridine Maleate

    85. 1-(n,n-dimethylamino)-3-(p-chlorophenyl-3-alpha-pyridyl)propane Maleate

    86. 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan Maleat [german]

    87. 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

    88. Chembl1659

    89. (y)-chlorpheniramine Maleate

    90. Chlorphenamini Hydrogenomaleas

    91. Schembl33357

    92. (?)-chlorpheniramine Maleate

    93. Mls000758311

    94. Mls001148230

    95. Mls001424173

    96. (+/-)-chlorpheniramine Maleate

    97. Hms501n18

    98. Hy-b0286a

    99. (a+/-)-chlorpheniramine Maleate

    100. Amf0009

    101. 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan Maleat

    102. Hms1568g16

    103. Hms2051l14

    104. Hms2093n19

    105. Hms2095g16

    106. Hms2230f21

    107. Hms2232b23

    108. Hms3260f04

    109. Hms3712g16

    110. Hms3884o10

    111. Pharmakon1600-01505530

    112. Tox21_500261

    113. Ac-267

    114. Chlorpheniramine Maleate [mi]

    115. Nsc759156

    116. S1816

    117. Chlorpheniramine Maleate (jp17/usp)

    118. Chlorpheniramine Maleate [jan]

    119. Akos015951220

    120. Chlorphenamine Maleate [mart.]

    121. Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

    122. Ccg-101036

    123. Ccg-220117

    124. Ccg-221565

    125. Chlorphenamine Maleate [who-dd]

    126. Lp00261

    127. Nc00286

    128. Nsc 756684

    129. 2-pyridinepropanamine, .gamma.-(4-chlorophenyl)-n,n-dimethyl-, (z)-2-butenedioate (1:1)

    130. 2-pyridinepropanamine, Gamma-(4-chlorophenyl)-n,n-dimethyl-, (z)-2-butenedioate (1:1)

    131. Chlorpheniramine Maleate [vandf]

    132. Chlorpheniramine Maleate [usp-rs]

    133. Ncgc00093720-01

    134. Ncgc00093720-02

    135. Ncgc00260946-01

    136. As-13167

    137. Smr000653461

    138. Chlorphenamine Maleate [ep Monograph]

    139. Eu-0100261

    140. Sw196372-4

    141. Chlorpheniramine Maleate [orange Book]

    142. C 3025

    143. C07780

    144. Chlorpheniramine Maleate [usp Monograph]

    145. Contac Component Chlorpheniramine Maleate

    146. D00665

    147. D70131

    148. Drize Component Chlorpheniramine Maleate

    149. Ornade Component Chlorpheniramine Maleate

    150. Chlorphenamine Hydrogen Maleate [who-ip]

    151. Demazin Component Chlorpheniramine Maleate

    152. Isoclor Component Chlorpheniramine Maleate

    153. ( Inverted Question Mark)-chlorpheniramine Maleate

    154. Chlorpheniramine Maleate Component Of Contac

    155. Chlorpheniramine Maleate Component Of Drize

    156. Chlorpheniramine Maleate Component Of Ornade

    157. Triaminic Component Chlorpheniramine Maleate

    158. Chlorphenamini Hydrogenomaleas [who-ip Latin]

    159. Chlorpheniramine Maleate 100 Microg/ml In Methanol

    160. Chlorpheniramine Maleate Component Of Demazin

    161. Chlorpheniramine Maleate Component Of Isoclor

    162. Sr-01000075261-1

    163. Sr-01000075261-9

    164. W-108612

    165. Chlorpheniramine Maleate Component Of Triaminic

    166. Q27106157

    167. F2173-0923

    168. Codimal-l.a. 12 Component Chlorpheniramine Maleate

    169. Advil Allergy Sinus Component Chlorpheniramine Maleate

    170. Chlorpheniramine Maleate Component Of Advil Allergy Sinus

    171. Chlorpheniramine Maleate Component Of Codimal-l.a. 12

    172. (+/-)-chlorpheniramine Maleate Salt >=99% (perchloric Acid Titration)

    173. (+/-)-chlorpheniramine Maleate Salt, >=99% (perchloric Acid Titration)

    174. [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine Maleate

    175. Chlorphenamine Maleate, European Pharmacopoeia (ep) Reference Standard

    176. 2-(p-chloro-.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

    177. 2-pyridinepropanamine, Gamma-(4-chlorophenyl)-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

    178. Chlorphenamine Maleate (chlorpheniramine Maleate) 1.0 Mg/ml In Methanol (as Free Base)

    179. Chlorpheniramine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material

    180. Chlorpheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

    181. Chlorpheniramine Maleate Salt Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.3.3 Other Synonyms

    1. Chlorpheniaramine Maleate

    2. Chloropheniramine Maleate

    3. Chlorphenamine Maleate

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 390.9 g/mol
    Molecular Formula C20H23ClN2O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass390.1346349 g/mol
    Monoisotopic Mass390.1346349 g/mol
    Topological Polar Surface Area90.7 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity368
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameChlorpheniramine maleate
    Drug LabelEd Chlortan Tablets are yellow, round, plain bottom, debossed "PH above 012" on top....
    Active IngredientChlorpheniramine maleate
    Dosage FormTablet, extended release
    RouteOral
    Strength12mg
    Market StatusOver the Counter
    CompanyAvanthi

    2 of 2  
    Drug NameChlorpheniramine maleate
    Drug LabelEd Chlortan Tablets are yellow, round, plain bottom, debossed "PH above 012" on top....
    Active IngredientChlorpheniramine maleate
    Dosage FormTablet, extended release
    RouteOral
    Strength12mg
    Market StatusOver the Counter
    CompanyAvanthi

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]