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    Cicletanine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
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    2D Structure
    Also known as: 82747-56-6, Cicletanine hcl, T0sy6373oq, 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride, Cicletanine hydrochloride (jan), Cicletanine hydrochloride [jan]
    Molecular Formula
    C14H13Cl2NO2
    Molecular Weight
    298.2  g/mol
    InChI Key
    QLMBAIRFQQLJJX-UHFFFAOYSA-N
    FDA UNII
    T0SY6373OQ
    Cicletanine Hydrochloride is the hydrochloride salt of a dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C14H12ClNO2.ClH/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9;/h2-6,14,17H,7H2,1H3;1H
    2.1.3 InChI Key
    QLMBAIRFQQLJJX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    T0SY6373OQ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,3-dihydro-6-methyl-7-hydroxy-3-(4-chlorophenyl)furo(3,4-d)pyridine

    2. Bn 1270

    3. Bn-1270

    4. Cicletanide

    5. Cicletanine

    6. Cycletanide

    7. Justar

    8. Tenstaten

    2.3.2 Depositor-Supplied Synonyms

    1. 82747-56-6

    2. Cicletanine Hcl

    3. T0sy6373oq

    4. 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride

    5. Cicletanine Hydrochloride (jan)

    6. Cicletanine Hydrochloride [jan]

    7. Unii-t0sy6373oq

    8. Tenstaten (tn)

    9. Justar (tn)

    10. Schembl387011

    11. Win-90000 Hcl

    12. Win 90,000 Hcl

    13. Dtxsid801002869

    14. Cicletanine Hydrochloride [mi]

    15. Akos030255878

    16. Cicletanine Hydrochloride [mart.]

    17. Cicletanine Hydrochloride [who-dd]

    18. Ft-0665030

    19. D07697

    20. Q27289519

    21. 3-(4-chlorophenyl)-6-methyl-1h,3h-furo[3,4-c]pyridin-7-ol Hydrochloride

    22. 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol,hydrochloride

    23. 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol--hydrogen Chloride (1/1)

    24. Furo(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, Hydrochloride

    25. Furo(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, Hydrochloride, (+/-)-

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 298.2 g/mol
    Molecular Formula C14H13Cl2NO2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count1
    Exact Mass297.0323340 g/mol
    Monoisotopic Mass297.0323340 g/mol
    Topological Polar Surface Area42.4 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity294
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)