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    Cifenline

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
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    2D Structure
    Also known as: 100678-32-8, Cifenline succinate, Cipralan, Cibenol, Cifenline succinate [usan], 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole succinate
    Molecular Formula
    C22H24N2O4
    Molecular Weight
    380.4  g/mol
    InChI Key
    XFUIOIWYMHEPIE-UHFFFAOYSA-N
    FDA UNII
    38G16RWJ37
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid;2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
    2.1.2 InChI
    InChI=1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    XFUIOIWYMHEPIE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN=C(N1)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4.C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    38G16RWJ37
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(2,2-diphenylcyclopropyl)-2-imidazoline

    2. Cibenzoline

    3. Cifenline

    4. Cifenline Succinate

    5. Cifenline, (s)-isomer

    6. Cipralan

    7. Exacor

    2.3.2 Depositor-Supplied Synonyms

    1. 100678-32-8

    2. Cifenline Succinate

    3. Cipralan

    4. Cibenol

    5. Cifenline Succinate [usan]

    6. 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole Succinate

    7. 85589-37-3

    8. Cibenzoline Succinate [jan]

    9. Ro 22-7796/001

    10. 38g16rwj37

    11. Butanedioic Acid, Compd. With 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole (1:1)

    12. Cipralan; Exacor; Ro 22-7796/001

    13. Ritmalan

    14. Exacor

    15. Butanedioic Acid;2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole

    16. Cifenline Succinate (usan)

    17. Cibenzoline Succinate (1:1)

    18. Ncgc00162222-01

    19. Ro-227796001

    20. Unii-38g16rwj37

    21. Cipralan (tn)

    22. Cibenol (tn)

    23. (+-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline Succinate (1:1)

    24. 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazole Succinate

    25. 1h-imidazole, 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-, Succinate

    26. 1h-imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+-)-, Butanedioate (1:1)

    27. Butanedioic Acid, Compd. With 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole

    28. Dsstox_cid_27797

    29. Dsstox_rid_82569

    30. Dsstox_gsid_47820

    31. Schembl121044

    32. Cibenzoline Succinate (jp17)

    33. Chembl3189111

    34. Cifenline Succinate [mi]

    35. Dtxsid0047820

    36. Chebi:31396

    37. Hms3262i07

    38. Tox21_112004

    39. Tox21_500683

    40. Akos016339647

    41. Cibenzoline Succinate [who-dd]

    42. Ccg-221987

    43. Ks-1343

    44. Lp00683

    45. Ro-227796

    46. Ncgc00261368-01

    47. Up-33901

    48. Cas-100678-32-8

    49. Ft-0623817

    50. Cibenzoline Succinate, >=97% (nmr), Solid

    51. D01455

    52. 678c328

    53. Ro-22-7796/001

    54. J-000196

    55. Q27256782

    56. 1-[2-(z)-methoxyimino-2-(2-aminothiazol-4-yl)acetoxy]benzotrizole

    57. (+/-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline Succinate (1:1)

    58. 1h-imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+/-)-, Butanedioate (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 380.4 g/mol
    Molecular Formula C22H24N2O4
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count6
    Exact Mass380.17360725 g/mol
    Monoisotopic Mass380.17360725 g/mol
    Topological Polar Surface Area99 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity450
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)