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    Cipro

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Ciprofloxacin hcl, 93107-08-5, 86483-48-9, 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, Cipro, Chebi:310388
    Molecular Formula
    C17H19ClFN3O3
    Molecular Weight
    367.8  g/mol
    InChI Key
    DIOIOSKKIYDRIQ-UHFFFAOYSA-N
    FDA UNII
    0MP32MFP6C
    A broad-spectrum antimicrobial carboxyfluoroquinoline.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
    2.1.3 InChI Key
    DIOIOSKKIYDRIQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0MP32MFP6C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anhydrous, Ciprofloxacin Hydrochloride

    2. Bay 09867

    3. Bay-09867

    4. Bay09867

    5. Ciprinol

    6. Cipro

    7. Ciprofloxacin

    8. Ciprofloxacin Hydrochloride Anhydrous

    9. Ciprofloxacin Monohydrochloride Monohydrate

    10. Hydrochloride Anhydrous, Ciprofloxacin

    11. Hydrochloride, Ciprofloxacin

    12. Monohydrate, Ciprofloxacin Monohydrochloride

    13. Monohydrochloride Monohydrate, Ciprofloxacin

    2.3.2 Depositor-Supplied Synonyms

    1. Ciprofloxacin Hcl

    2. 93107-08-5

    3. 86483-48-9

    4. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

    5. Cipro

    6. Chebi:310388

    7. Ciprofloxacin Hydrochloride Anhydrous

    8. 0mp32mfp6c

    9. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hydrochloride

    10. Ciprofloxacin (monohydrochloride)

    11. Bay-o-9867

    12. Ciprofloxacin Hydrochloride (anh.)

    13. Bay O 9867

    14. Cetraxal

    15. Ciprobay

    16. Ciproxan

    17. Ciproxin

    18. Flociprin

    19. Ciflox

    20. Mfcd00079044

    21. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hcl

    22. 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic Acid;hydrochloride

    23. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Xhydrochloride

    24. Bay-o 9867

    25. 93107-08-5 (hcl)

    26. 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic Acid Hydrochloride

    27. Dsstox_cid_27768

    28. Dsstox_rid_82545

    29. Dsstox_gsid_47788

    30. Ciprofloxacin (as Hydrochloride)

    31. Prestwick_67

    32. 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic Acid; Hydrochloride

    33. 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinolin-7-yl)-piperazin-1-ium; Chloride

    34. Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride

    35. Nsc620634

    36. Ciprofloxacin Hydrochloride (anhydrous)

    37. Ciprofloxacin 100 Microg/ml In Methanol

    38. Ncgc00016959-01

    39. Cas-93107-08-5

    40. Unii-0mp32mfp6c

    41. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Hydrochloride

    42. 3-quiolinecarboxylic Acid

    43. Ciprofloxacine Hydrochloride

    44. Epitope Id:174846

    45. Cambridge Id 5807784

    46. Ciprofloxacini Hydrochloridum

    47. Chembl1202

    48. Schembl42310

    49. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Monohydrochloride

    50. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Monohydrochloride

    51. Ciprofloxacin Hcl/lactate

    52. Dtxsid1047788

    53. Hy-b0356a

    54. Ciprofloxacin Hydrochloride (1:x)

    55. Hms1568g08

    56. Bcp13634

    57. Bcp14336

    58. Tox21_110712

    59. S5008

    60. Akos005111008

    61. Tox21_110712_1

    62. Cs-8134

    63. Ks-5012

    64. Nsc-620634

    65. Sb73037

    66. Ncgc00016959-06

    67. 3-quinolinecarboxylic Acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-, Hydrochloride

    68. Ac-23972

    69. Bim-0048462.p001

    70. Ciprofloxacin 1000 Microg/ml In Methanol

    71. Ciprofloxacin Hydrochloride [who-dd]

    72. Ft-0623850

    73. Ft-0623851

    74. A16969

    75. H10663

    76. A859872

    77. Q-200860

    78. Q27105154

    79. F0001-2378

    80. Cpx; Cetraxal; Ciloxan; Cipro; Bay-09867 Hydrochloride

    81. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hcl

    82. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacidxhydrochloride

    83. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Hydrochloride (1:1)

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 367.8 g/mol
    Molecular Formula C17H19ClFN3O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count3
    Exact Mass367.1098973 g/mol
    Monoisotopic Mass367.1098973 g/mol
    Topological Polar Surface Area72.9 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity571
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCiprofloxacin hydrochloride
    PubMed HealthCiprofloxacin Betaine/Ciprofloxacin Hydrochloride (By mouth)
    Drug ClassesAntibacterial
    Drug LabelCiprofloxacin Tablets, USPis a synthetic broad spectrum antimicrobial agent for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pip...
    Active IngredientCiprofloxacin hydrochloride
    Dosage FormSolution/drops; Tablet
    RouteOphthalmic; Oral
    Strengtheq 100mg base; eq 750mg base; eq 500mg base; eq 0.3% base; eq 250mg base
    Market StatusPrescription
    CompanyWatson Labs; Nexus Pharms; Ranbaxy; Ivax Sub Teva Pharms; Apotex; Bausch And Lomb; Aurobindo Pharma; Taro; Dr Reddys Labs; Unique Pharm Labs; Carlsbad; Pharmaforce; Fdc; Mylan; Hikma; Akorn

    2 of 2  
    Drug NameCiprofloxacin hydrochloride
    PubMed HealthCiprofloxacin Betaine/Ciprofloxacin Hydrochloride (By mouth)
    Drug ClassesAntibacterial
    Drug LabelCiprofloxacin Tablets, USPis a synthetic broad spectrum antimicrobial agent for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pip...
    Active IngredientCiprofloxacin hydrochloride
    Dosage FormSolution/drops; Tablet
    RouteOphthalmic; Oral
    Strengtheq 100mg base; eq 750mg base; eq 500mg base; eq 0.3% base; eq 250mg base
    Market StatusPrescription
    CompanyWatson Labs; Nexus Pharms; Ranbaxy; Ivax Sub Teva Pharms; Apotex; Bausch And Lomb; Aurobindo Pharma; Taro; Dr Reddys Labs; Unique Pharm Labs; Carlsbad; Pharmaforce; Fdc; Mylan; Hikma; Akorn

    4.2 Drug Indication

    Treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Topoisomerase II Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

    Cytochrome P-450 CYP1A2 Inhibitors

    Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Quinolones [CS]; Quinolone Antimicrobial [EPC]