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    Clindamycin Palmitate Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Clindamycin palmitate hcl, 25507-04-4, Cleocin pediatric, Clindamycin 2-palmitate hydrochloride, Vn9a8jm7m7, U-25,179 e
    Molecular Formula
    C34H64Cl2N2O6S
    Molecular Weight
    699.9  g/mol
    InChI Key
    GTNDZRUWKHDICY-DJHAJVGHSA-N
    FDA UNII
    VN9A8JM7M7
    Clindamycin Palmitate Hydrochloride is the palmitate hydrochloride form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin palmitate hydrochloride is used for oral suspension.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] hexadecanoate;hydrochloride
    2.1.2 InChI
    InChI=1S/C34H63ClN2O6S.ClH/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-21-27(38)42-32-30(40)29(39)31(43-34(32)44-5)28(24(3)35)36-33(41)26-22-25(20-7-2)23-37(26)4;/h24-26,28-32,34,39-40H,6-23H2,1-5H3,(H,36,41);1H/t24-,25+,26-,28+,29+,30-,31+,32+,34+;/m0./s1
    2.1.3 InChI Key
    GTNDZRUWKHDICY-DJHAJVGHSA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCCCCC(=O)OC1C(C(C(OC1SC)C(C(C)Cl)NC(=O)C2CC(CN2C)CCC)O)O.Cl
    2.1.5 Isomeric SMILES
    CCCCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1SC)[C@@H]([C@H](C)Cl)NC(=O)[C@@H]2C[C@H](CN2C)CCC)O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    VN9A8JM7M7
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 7-chloro-7-deoxylincomycin Palmitate

    2. 7-chlorolincomycin Palmitate

    3. Cleocin Palmitate

    4. Clindamycin Palmitate

    2.3.2 Depositor-Supplied Synonyms

    1. Clindamycin Palmitate Hcl

    2. 25507-04-4

    3. Cleocin Pediatric

    4. Clindamycin 2-palmitate Hydrochloride

    5. Vn9a8jm7m7

    6. U-25,179 E

    7. 25507-04-4 (palmitate Hcl)

    8. Nsc-759141

    9. U-25179e

    10. U-25179-e

    11. Clindamycin Palmitate (hydrochloride)

    12. (2r,3r,4s,5r,6r)-6-((1s,2s)-2-chloro-1-((2s,4r)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2h-pyran-3-yl Palmitate

    13. (2r,3r,4s,5r,6r)-6-((1s,2s)-2-chloro-1-((2s,4r)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2h-pyran-3-yl Palmitate Hydrochloride

    14. [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] Hexadecanoate;hydrochloride

    15. Unii-vn9a8jm7m7

    16. Ncgc00185773-02

    17. U 25179e

    18. Cleocin Pediatric (tn)

    19. Dsstox_cid_28660

    20. Dsstox_rid_82930

    21. Dsstox_gsid_48734

    22. Schembl41416

    23. Clindamycin Palmitate Hydrochloride [usan:usp:jan]

    24. Chembl1200632

    25. Dtxsid3048734

    26. Niosh/gf2450000

    27. Chebi:34647

    28. Hy-b1454

    29. Tox21_113175

    30. Mfcd09752824

    31. Akos030242182

    32. Ccg-270385

    33. Nsc 759141

    34. As-58470

    35. Clindamycin-2-palmitate, Monohydrochloride

    36. Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside 2-palmitate Monohydrochloride

    37. Cas-25507-04-4

    38. Cs-0013162

    39. Gf24500000

    40. Clindamycin Palmitate Hydrochloride (jan/usp)

    41. D01990

    42. F20748

    43. Clindamycin Palmitate Hydrochloride [jan]

    44. Clindamycin Palmitate Hydrochloride [mart.]

    45. Clindamycin Palmitate Hydrochloride [usan]

    46. Clindamycin Palmitate Hydrochloride [vandf]

    47. Clindamycin Palmitate Hydrochloride [usp-rs]

    48. Clindamycin Palmitate Hydrochloride [who-dd]

    49. J-016026

    50. Q27291919

    51. Clindamycin Palmitate Hydrochloride [orange Book]

    52. Clindamycin Palmitate Hydrochloride [usp Monograph]

    53. L-threo-.alpha.-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-2-hexadecanoate, Monohydrochloride, (2s-trans)-

    54. L-threo-alpha-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-2-hexadecanoate, Monohydrochloride, (2s-trans)-

    55. Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-.alpha.-d-galacto-octopyranoside 2-palmitate Monohydrochloride

    2.4 Create Date
    2007-05-07
    3 Chemical and Physical Properties
    Molecular Weight 699.9 g/mol
    Molecular Formula C34H64Cl2N2O6S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count23
    Exact Mass698.3862143 g/mol
    Monoisotopic Mass698.3862143 g/mol
    Topological Polar Surface Area134 Ų
    Heavy Atom Count45
    Formal Charge0
    Complexity810
    Isotope Atom Count0
    Defined Atom Stereocenter Count9
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameClindamycin palmitate hydrochloride
    Drug LabelClindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compoun...
    Active IngredientClindamycin palmitate hydrochloride
    Dosage FormFor solution
    RouteOral
    Strengtheq 75mg base/5ml
    Market StatusPrescription
    CompanyLyne; Amneal Pharms; Paddock Labs; Aurobindo Pharma

    2 of 2  
    Drug NameClindamycin palmitate hydrochloride
    Drug LabelClindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compoun...
    Active IngredientClindamycin palmitate hydrochloride
    Dosage FormFor solution
    RouteOral
    Strengtheq 75mg base/5ml
    Market StatusPrescription
    CompanyLyne; Amneal Pharms; Paddock Labs; Aurobindo Pharma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Protein Synthesis Inhibitors

    Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Lincosamide Antibacterial [EPC]; Lincosamides [CS]; Neuromuscular Blockade [PE]; Decreased Sebaceous Gland Activity [PE]