1. Clobetasol
2. Clobetasol 17 Propionate
3. Clobetasol 17-propionate
4. Clobex
5. Clofenazon
6. Cormax
7. Dermovate
8. Embeline
9. Embeline E
10. Olux
11. Temovate
1. 25122-46-7
2. Clobetasol 17-propionate
3. Clobex
4. Dermovate
5. Temovate
6. Embeline
7. Cormax
8. Olux
9. Gr 2/925
10. Cci 4725
11. Clobestasol Propionate
12. Impoyz
13. Psorex
14. [(8s,9r,10s,11s,13s,14s,16s,17r)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Propanoate
15. Clobetasol 17-propanoate
16. Clobetasol-17-propionate
17. Mls000028708
18. Cci-4725
19. 21-chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
20. Embeline E
21. Smr000058745
22. Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)-
23. Clobesol
24. Chebi:31414
25. Temovate E
26. Nsc-758634
27. Dsstox_cid_25907
28. Dsstox_rid_81219
29. Dsstox_gsid_45907
30. Olux-e
31. 779619577m
32. Dermoxinale
33. Butavate
34. Dermoval
35. Yugofin
36. 21-chloro-9-fluoro-11beta-hydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Propanoate
37. Olux E
38. Cgp 9555
39. Clobetasol Propionate Gel
40. Einecs 246-634-3
41. Clobetasol Propionate (emollient)
42. Clarelux
43. Ncgc00095078-01
44. Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11.beta.,16.beta.)-
45. Clobetasol-propionate
46. Cas-25122-46-7
47. Clobex (tn)
48. Cormax (tn)
49. Mfcd00058499
50. Unii-779619577m
51. Impeklo
52. Clobetasol Propionate [usan:usp:jan]
53. Olux (tn)
54. Clobetasol Propionate E
55. Propionic Acid Clobetasol
56. Opera_id_1470
57. Schembl3997
58. 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)-
59. Cid_32798
60. Mls001076345
61. Amot0927
62. Gtpl7062
63. Ccl 4725
64. Chembl1159650
65. Dtxsid6045907
66. Bdbm39347
67. Cgp9555
68. Clobetasol Propionate [mi]
69. Hms2090a04
70. Hms2230h08
71. Hms3259a10
72. Hms3714m04
73. Clobetasol Propionate (jp17/usp)
74. Clobetasol Propionate [jan]
75. Bcp04125
76. Zinc3977767
77. Clobetasol Propionate [usan]
78. Tox21_111414
79. Am9637
80. Clobetasol Propionate [vandf]
81. S2584
82. Clobetasol Propionate [mart.]
83. Akos015951278
84. Clobetasol Propionate [usp-rs]
85. Clobetasol Propionate [who-dd]
86. Tox21_111414_1
87. Bcp9000539
88. Ccg-220781
89. Clobetasol 17-propionate [mi]
90. Db01013
91. Nc00551
92. Nsc 758634
93. 21-chloro-9-fluoro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
94. Ncgc00023373-03
95. Ncgc00023373-04
96. Ac-17990
97. As-12555
98. Clobetasol Propionate, Analytical Standard
99. Cpd000058745
100. Gr-2/925
101. Hy-13600
102. Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate
103. Bcp0726000094
104. Clobetasol Propionate [orange Book]
105. Clobetasol Propionate [usp Impurity]
106. Clobetasol Propionate [usp Monograph]
107. D01272
108. D94623
109. Ab00383081-10
110. Ab00383081_11
111. 122c467
112. Clobetasol Propionate 1000 Microg/ml In Methanol
113. Q421637
114. Sr-01000000280
115. Clobetasol Propionate 100 Microg/ml In Acetonitrile
116. Sr-01000000280-4
117. Brd-k10799896-001-10-6
118. Brd-k10799896-001-26-2
119. Clobetasol Propionate 100 Microg/ml In Methanol/water
120. Clobetasol Propionate, European Pharmacopoeia (ep) Reference Standard
121. Clobetasol Propionate, United States Pharmacopeia (usp) Reference Standard
122. Clobetasol For Peak Identification, European Pharmacopoeia (ep) Reference Standard
123. Clobetasol Propionate, Pharmaceutical Secondary Standard; Certified Reference Material
124. (8alpha,11beta,14beta,16alpha,17alpha)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl Propanoate
125. 21-chloro-9-fluoro-11.beta.,17-dihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17-propionate
126. 21-chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-propionate
127. Cgp9555 Pound>> Ccl 4725 Pound>>cgp 9555 Pound>> Ccl4725 Pound>>cgp-9555 Pound>> Ccl-4725
128. Xrd
| Molecular Weight | 467.0 g/mol |
|---|---|
| Molecular Formula | C25H32ClFO5 |
| XLogP3 | 3.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 466.1922300 g/mol |
| Monoisotopic Mass | 466.1922300 g/mol |
| Topological Polar Surface Area | 80.7 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 929 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 20 | |
|---|---|
| Drug Name | Clobetasol propionate |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Lotion; Gel; Shampoo; Ointment; Cream; Spray; Aerosol, foam; Solution |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Wockhardt; Fougera Pharms; Teva Pharms; Paddock; Actavis Mid Atlantic; Perrigo; Taro; Fougera; Tolmar; Perrigo Israel |
| 2 of 20 | |
|---|---|
| Drug Name | Clobetasol propionate |
| PubMed Health | Clobetasol Propionate (On the skin) |
| Drug Classes | Corticosteroid, Very Strong |
| Drug Label | Clobetasol propionate cream USP, 0.05% (emollient) contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degre... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms; Taro |
| 3 of 20 | |
|---|---|
| Drug Name | Clobex |
| Drug Label | CLOBEX (clobetasol propionate) Lotion, 0.05% contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflamm... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Lotion; Shampoo; Spray |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Galderma Labs |
| 4 of 20 | |
|---|---|
| Drug Name | Cormax |
| PubMed Health | Clobetasol Propionate (On the skin) |
| Drug Classes | Corticosteroid, Very Strong |
| Drug Label | Cormax Ointment contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Hi Tech Pharma |
| 5 of 20 | |
|---|---|
| Drug Name | Embeline |
| Drug Label | Clobetasol propionate foam, 0.05% contains clobetasol propionate, USP, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocortic... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Gel; Ointment; Solution |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Hi Tech Pharma |
| 6 of 20 | |
|---|---|
| Drug Name | Embeline e |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Hi Tech Pharma |
| 7 of 20 | |
|---|---|
| Drug Name | Olux |
| PubMed Health | Clobetasol |
| Drug Classes | Corticosteroid, Very Strong, Corticosteroid, Weak |
| Drug Label | OLUX-E (clobetasol propionate) Foam, 0.05% is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient clobetasol propionate USP, a synthetic corticosteroid for topical dermatologic use. Clobetasol, an analog of pr... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Aerosol, foam |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Delcor Asset |
| 8 of 20 | |
|---|---|
| Drug Name | Olux e |
| PubMed Health | Clobetasol |
| Drug Classes | Corticosteroid, Very Strong, Corticosteroid, Weak |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Aerosol, foam |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Delcor Asset |
| 9 of 20 | |
|---|---|
| Drug Name | Temovate |
| PubMed Health | Clobetasol |
| Drug Classes | Corticosteroid, Very Strong, Corticosteroid, Weak |
| Drug Label | Temovate E (clobetasol propionate) Cream, 0.05% contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Ointment; Cream; Gel |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms |
| 10 of 20 | |
|---|---|
| Drug Name | Temovate e |
| PubMed Health | Clobetasol Propionate (On the skin) |
| Drug Classes | Corticosteroid, Very Strong |
| Drug Label | Temovate E (clobetasol propionate) Cream, 0.05% contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms |
| 11 of 20 | |
|---|---|
| Drug Name | Clobetasol propionate |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Lotion; Gel; Shampoo; Ointment; Cream; Spray; Aerosol, foam; Solution |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Wockhardt; Fougera Pharms; Teva Pharms; Paddock; Actavis Mid Atlantic; Perrigo; Taro; Fougera; Tolmar; Perrigo Israel |
| 12 of 20 | |
|---|---|
| Drug Name | Clobetasol propionate |
| PubMed Health | Clobetasol Propionate (On the skin) |
| Drug Classes | Corticosteroid, Very Strong |
| Drug Label | Clobetasol propionate cream USP, 0.05% (emollient) contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degre... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms; Taro |
| 13 of 20 | |
|---|---|
| Drug Name | Clobex |
| Drug Label | CLOBEX (clobetasol propionate) Lotion, 0.05% contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflamm... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Lotion; Shampoo; Spray |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Galderma Labs |
| 14 of 20 | |
|---|---|
| Drug Name | Cormax |
| PubMed Health | Clobetasol Propionate (On the skin) |
| Drug Classes | Corticosteroid, Very Strong |
| Drug Label | Cormax Ointment contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Hi Tech Pharma |
| 15 of 20 | |
|---|---|
| Drug Name | Embeline |
| Drug Label | Clobetasol propionate foam, 0.05% contains clobetasol propionate, USP, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocortic... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Gel; Ointment; Solution |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Hi Tech Pharma |
| 16 of 20 | |
|---|---|
| Drug Name | Embeline e |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Hi Tech Pharma |
| 17 of 20 | |
|---|---|
| Drug Name | Olux |
| PubMed Health | Clobetasol |
| Drug Classes | Corticosteroid, Very Strong, Corticosteroid, Weak |
| Drug Label | OLUX-E (clobetasol propionate) Foam, 0.05% is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient clobetasol propionate USP, a synthetic corticosteroid for topical dermatologic use. Clobetasol, an analog of pr... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Aerosol, foam |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Delcor Asset |
| 18 of 20 | |
|---|---|
| Drug Name | Olux e |
| PubMed Health | Clobetasol |
| Drug Classes | Corticosteroid, Very Strong, Corticosteroid, Weak |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Aerosol, foam |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Delcor Asset |
| 19 of 20 | |
|---|---|
| Drug Name | Temovate |
| PubMed Health | Clobetasol |
| Drug Classes | Corticosteroid, Very Strong, Corticosteroid, Weak |
| Drug Label | Temovate E (clobetasol propionate) Cream, 0.05% contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Ointment; Cream; Gel |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms |
| 20 of 20 | |
|---|---|
| Drug Name | Temovate e |
| PubMed Health | Clobetasol Propionate (On the skin) |
| Drug Classes | Corticosteroid, Very Strong |
| Drug Label | Temovate E (clobetasol propionate) Cream, 0.05% contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree... |
| Active Ingredient | Clobetasol propionate |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms |
Clobetasol propionate is indicated to treat moderate to severe plaque psoriasis as well as inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
FDA Label
Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Clobetasol propionate is generally applied twice daily so the duration of action is long. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)
Absorption
Twice daily application of clobetasol foam leads to a Cmax of 5936pg/mL with a Tmax of 5 hours. Clobetasol cream showed an increase in clobetasol concentrations from 50.796.0pg/mL to 56.3104.7pg/mL.
Route of Elimination
Corticosteroids are eliminated predominantly in the urine.
Volume of Distribution
Data regarding the volume of distribution of clobetasole propionate are not readily available.
Clearance
Data regarding the clearance of clobetasol propionate are not readily available.
The metabolism of clobetasol propionate is not well studied but it does induce metabolic enzymes, even when delivered topically. The metabolism of clobetasol propionate is predicted to follow similar metabolic pathways to other corticosteroids including the addition of oxygen, hydrogen, glucuronides, and sulfates to form water soluble metabolites.
Data regarding the half life of clobetasol propionate are not readily available.
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.
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