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    Clobetasone Butyrate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 4,206Xls

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    2D Structure
    Also known as: 25122-57-0, Clobetasone 17-butyrate, Cci 5537, Kindavate, Gr 2/1214, 8u0h6xi6eo
    Molecular Formula
    C26H32ClFO5
    Molecular Weight
    479.0  g/mol
    InChI Key
    FBRAWBYQGRLCEK-AVVSTMBFSA-N
    FDA UNII
    8U0H6XI6EO
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate
    2.1.2 InChI
    InChI=1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1
    2.1.3 InChI Key
    FBRAWBYQGRLCEK-AVVSTMBFSA-N
    2.1.4 Canonical SMILES
    CCCC(=O)OC1(C(CC2C1(CC(=O)C3(C2CCC4=CC(=O)C=CC43C)F)C)C)C(=O)CCl
    2.1.5 Isomeric SMILES
    CCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(CC(=O)[C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)C)C)C(=O)CCl
    2.2 Other Identifiers
    2.2.1 UNII
    8U0H6XI6EO
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 21-chloro-11-dehydro-betamethasone-17-butyrate

    2. Clobetasone 17-butyrate

    3. Emovate

    4. Eumovate

    5. Trimovate

    2.3.2 Depositor-Supplied Synonyms

    1. 25122-57-0

    2. Clobetasone 17-butyrate

    3. Cci 5537

    4. Kindavate

    5. Gr 2/1214

    6. 8u0h6xi6eo

    7. 21-chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

    8. 21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

    9. Gnf-pf-1500

    10. Mls000028658

    11. Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16beta)-

    12. Emovate

    13. Molivate

    14. Smr000058879

    15. Dsstox_cid_26823

    16. Dsstox_rid_81935

    17. Dsstox_gsid_46823

    18. [(8s,9r,10s,13s,14s,16s,17r)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-17-yl] Butanoate

    19. Cloptison

    20. Cas-25122-57-0

    21. Clobetasone Butyrate [usan:jan]

    22. Einecs 246-635-9

    23. Sn 203

    24. Unii-8u0h6xi6eo

    25. Cci-5537

    26. Clofasone Butyrate

    27. Kindavate (tn)

    28. Ncgc00181043-01

    29. Clobetasone-butyrate

    30. Mfcd00133196

    31. Butyric Acid Clobetasone

    32. Opera_id_1547

    33. 21-chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione Butyrate

    34. 21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione Butyrate

    35. Schembl36599

    36. Mls001076290

    37. Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16-beta)-

    38. Clobetasone Butyrate, >=98%

    39. Chembl577673

    40. Dtxsid3046823

    41. Chebi:31415

    42. Clobetasone Butyrate (jan/usan)

    43. Clobetasone Butyrate [jan]

    44. Hms2234b13

    45. Clobetasone Butyrate [usan]

    46. Hy-b1616

    47. Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16.beta.)-

    48. Zinc4215391

    49. Tox21_112691

    50. Clobetasone Butyrate [mart.]

    51. S6587

    52. Clobetasone Butyrate [who-dd]

    53. Akos037748814

    54. Clobetasone 17-butyrate [mi]

    55. Tox21_112691_1

    56. Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-, Butyrate

    57. Ncgc00022019-03

    58. As-14689

    59. Clobetasone Butyrate [ep Monograph]

    60. Clobetasone Butyrate For System Suitability

    61. Gr-2/1214

    62. C3510

    63. Cs-0013549

    64. D01273

    65. T70655

    66. 122c570

    67. A924946

    68. Sr-01000000249

    69. Clobetasone Butyrate 100 Microg/ml In Acetonitrile

    70. Sr-01000000249-3

    71. W-107264

    72. Q27271005

    73. Clobetasone Butyrate, European Pharmacopoeia (ep) Reference Standard

    74. (16beta)-21-chloro-9-fluoro-16-methyl-3,11,20-trioxopregna-1,4-dien-17-yl Butyrate

    75. Clobetasone Butyrate For System Suitability, European Pharmacopoeia (ep) Reference Standard

    76. 21-chloro-9-fluoro-17-hydroxy-16.beta.-methylpregna-1,4-diene-3,11,20-trione Butyrate

    77. Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 479.0 g/mol
    Molecular Formula C26H32ClFO5
    XLogP33.8
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass478.1922300 g/mol
    Monoisotopic Mass478.1922300 g/mol
    Topological Polar Surface Area77.5 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity987
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)