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    Clodronic Acid Disodium Salt

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    2D Structure
    Also known as: 22560-50-5, Clodronic acid disodium salt, Disodium clodronate, Clasteon, Loron, Lodronate
    Molecular Formula
    CH2Cl2Na2O6P2
    Molecular Weight
    288.85  g/mol
    InChI Key
    HJKBJIYDJLVSAO-UHFFFAOYSA-L
    FDA UNII
    Y05R4GCQ1H
    A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
    2.1.2 InChI
    InChI=1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
    2.1.3 InChI Key
    HJKBJIYDJLVSAO-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    Y05R4GCQ1H
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acid, Clodronic

    2. Acid, Dichloromethanediphosphonic

    3. Biphosphonate, Dichloromethylene

    4. Bonefos

    5. Cl2mdp

    6. Clodronate

    7. Clodronate Sodium

    8. Clodronic Acid

    9. Dichloromethane Diphosphonate

    10. Dichloromethanediphosphonate

    11. Dichloromethanediphosphonic Acid

    12. Dichloromethylene Biphosphonate

    13. Dichloromethylene Diphosphonate

    14. Dichloromethylenebisphosphonate

    15. Diphosphonate, Dichloromethane

    16. Diphosphonate, Dichloromethylene

    17. Disodium, Clodronate

    18. Sodium, Clodronate

    2.3.2 Depositor-Supplied Synonyms

    1. 22560-50-5

    2. Clodronic Acid Disodium Salt

    3. Disodium Clodronate

    4. Clasteon

    5. Loron

    6. Lodronate

    7. Ostac

    8. Clodronate Sodium

    9. Sodium Clodronate

    10. Bonefos

    11. Clodronate Disodium Anhydrous

    12. Disodium Dichloromethylene Diphosphonate

    13. Disodium (dichloromethylene)diphosphonate

    14. Disodium (dichloromethylene)bisphosphonate

    15. Clodronate (disodium Salt)

    16. Disodium Dihydrogen (dichloromethylene)diphosphonate

    17. Y05r4gcq1h

    18. Chebi:59586

    19. Clastoban

    20. Clodronic Acid (disodium Salt)

    21. Ncgc00016141-02

    22. Dichloromethylenediphosphonic Acid Disodium Salt

    23. Mebonat

    24. Ossiten

    25. Bonefos (tn)

    26. Sodium (dichloro(phosphono)methyl)phosphonate

    27. Chlodronate Sodium

    28. Phosphonic Acid, (dichloromethylene)bis-, Disodium Salt

    29. Sodium Clodronate Hydrate

    30. Clodronate, Disodium Salt

    31. Clodron

    32. 88416-50-6

    33. Dichloromethane Diphosphonate

    34. Cl2mdp

    35. Einecs 245-078-9

    36. Unii-y05r4gcq1h

    37. Disodium-dichloromethylene-diphosphonate

    38. Abioklad

    39. Bm 06011

    40. Clodronic Acid, Disodium Salt

    41. Lytos

    42. Clodronate 2na

    43. Dichloromethylene Diphosphonate, Disodium Salt

    44. Lopac-d-4434

    45. Dsstox_cid_25225

    46. Dsstox_rid_80762

    47. Dsstox_gsid_45225

    48. Schembl28438

    49. Phosphonic Acid, (dichloromethylene)di-, Disodium Salt

    50. Chembl1520188

    51. Dtxsid3045225

    52. Kco-692

    53. Hms3261o17

    54. Tox21_110309

    55. Tox21_500398

    56. Clodronate Disodium [who-dd]

    57. Mfcd01632786

    58. S4108

    59. Clodronic Acid Disodium Salt Anhydrous

    60. Akos005766025

    61. Ccg-220684

    62. Ccg-221702

    63. Lp00398

    64. Clodronic Acid, Disodium Salt, Hydrate

    65. Ncgc00016141-01

    66. Ncgc00093825-01

    67. Ncgc00261083-01

    68. Cas-22560-50-5

    69. Db-013842

    70. D4160

    71. Eu-0100398

    72. D 4434

    73. D07720

    74. F20591

    75. Sodium Dichloromethylenebis(hydrogenphosphonate)

    76. (dichloromethylene)bisphosphonate Disodium

    77. A816262

    78. Dichloromethylenediphosphonic Acid Disodium Salt

    79. 22560-50-5, 10596-23-3(free Base)

    80. Clodronic Acid Disodium Salt Anhydrous [mi]

    81. Cl2mdp; Clodronic Acid Disodium Magnesium Salt; Dmdp

    82. Q27126793

    83. Disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]

    84. Disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 288.85 g/mol
    Molecular Formula CH2Cl2Na2O6P2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count2
    Exact Mass287.8499057 g/mol
    Monoisotopic Mass287.8499057 g/mol
    Topological Polar Surface Area121 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity206
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)