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    Clotiazepam

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 3,371Xls

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    2D Structure
    Also known as: Rize, Trecalmo, Rizen, Tienor, Rise, 33671-46-4
    Molecular Formula
    C16H15ClN2OS
    Molecular Weight
    318.8  g/mol
    InChI Key
    CHBRHODLKOZEPZ-UHFFFAOYSA-N
    FDA UNII
    ZCN055599V
    Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
    2.1.2 InChI
    InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
    2.1.3 InChI Key
    CHBRHODLKOZEPZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCC1=CC2=C(S1)N(C(=O)CN=C2C3=CC=CC=C3Cl)C
    2.2 Other Identifiers
    2.2.1 UNII
    ZCN055599V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Y 6047

    2. Y-6047

    3. Y6047

    2.3.2 Depositor-Supplied Synonyms

    1. Rize

    2. Trecalmo

    3. Rizen

    4. Tienor

    5. Rise

    6. 33671-46-4

    7. Clotiazepamum [inn-latin]

    8. Y 6047

    9. 5-(2-chlorophenyl)-7-ethyl-1-methyl-3h-thieno[2,3-e][1,4]diazepin-2-one

    10. 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2h-thieno(2,3-e)-1,4-diazepin-2-one

    11. 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno(2,3-e)(1,4)diazepin-2-one

    12. Zcn055599v

    13. 2h-thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

    14. 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno[2,3-e][1,4]diazepin-2-one

    15. Clotiazepamum

    16. Distensan

    17. Veratran

    18. Clozan

    19. Clotiazepam [inn:jan]

    20. 2h-thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-

    21. 2h-thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

    22. Rize (tn)

    23. Einecs 251-627-3

    24. Brn 0623332

    25. Unii-zcn055599v

    26. Dea No. 2752

    27. Y-6047

    28. Clotiazepam [mi]

    29. Clotiazepam [inn]

    30. Clotiazepam [jan]

    31. Clotiazepam (jp17/inn)

    32. Clotiazepam [mart.]

    33. Schembl44592

    34. Clotiazepam [who-dd]

    35. Zinc1207

    36. Chembl1697737

    37. Dtxsid0022852

    38. Chebi:31425

    39. Hy-u00317

    40. Akos005065735

    41. Cs-7319

    42. Db01559

    43. D01328

    44. Q2263999

    45. 2h-thieno[2,3-e]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

    46. 5-(2-chlorophenyl)-7-ethyl-1-methyl-1h,2h,3h-thieno[2,3-e][1,4]diazepin-2-one

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 318.8 g/mol
    Molecular Formula C16H15ClN2OS
    XLogP33.5
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count2
    Exact Mass318.0593620 g/mol
    Monoisotopic Mass318.0593620 g/mol
    Topological Polar Surface Area60.9 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity442
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For the treatment of anxiety disorders.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It increases the stage 2 non-rapid eye movement sleep.

    5.2 ATC Code

    N05BA21

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N05 - Psycholeptics

    N05B - Anxiolytics

    N05BA - Benzodiazepine derivatives

    N05BA21 - Clotiazepam

    5.3 Metabolism/Metabolites

    Hepatic.

    Clotiazepam has known human metabolites that include Hydroxy-clotiazepam and desmethyl-clotiazepam.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.4 Biological Half-Life

    4 hours

    5.5 Mechanism of Action

    Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons.