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    Coleus Forskohlii Extract

    ACTIVE PHARMA INGREDIENTS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 201Xls

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    2D Structure
    Also known as: Colforsin, 66575-29-9, Coleonol, Colforsina, Colforsine, Colforsinum
    Molecular Formula
    C22H34O7
    Molecular Weight
    410.5  g/mol
    InChI Key
    OHCQJHSOBUTRHG-KGGHGJDLSA-N
    FDA UNII
    1F7A44V6OU
    Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
    2.1.2 InChI
    InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
    2.1.3 InChI Key
    OHCQJHSOBUTRHG-KGGHGJDLSA-N
    2.1.4 Canonical SMILES
    CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
    2.1.5 Isomeric SMILES
    CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
    2.2 Other Identifiers
    2.2.1 UNII
    1F7A44V6OU
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Coleonol

    2. Colforsin

    3. N,n-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1h-naphtho(2,1-b)pyran-6-yl Ester Hcl

    4. Nkh 477

    5. Nkh-477

    6. Nkh477

    2.3.2 Depositor-Supplied Synonyms

    1. Colforsin

    2. 66575-29-9

    3. Coleonol

    4. Colforsina

    5. Colforsine

    6. Colforsinum

    7. Boforsin

    8. Hl 362

    9. Coleonolk

    10. L 75 1362b

    11. Forskolin (gmp)

    12. 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one

    13. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1h-benzo[f]chromen-5-yl Acetate

    14. Hl-362

    15. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1h-benzo[f]chromen-5-yl Acetate

    16. Chembl52606

    17. L-751362b

    18. 1f7a44v6ou

    19. [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-5-yl] Acetate

    20. Chebi:42471

    21. Nsc375489

    22. Nsc-357088

    23. Nsc-375489

    24. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1h-naphtho(2,1-b)pyran-1-one 5-acetate

    25. Ncgc00024996-02

    26. L-75-1362b

    27. 66428-89-5

    28. Dsstox_cid_20484

    29. Dsstox_rid_79500

    30. Dsstox_gsid_40484

    31. 1h-naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3r,4ar,5s,6s,6as,10s,10ar,10bs)-

    32. Colforsine [french]

    33. Colforsinum [latin]

    34. Colforsina [spanish]

    35. Forslean

    36. Colforsin [usan:inn]

    37. Fok

    38. Smr000471881

    39. Cas-66575-29-9

    40. C22h34o7

    41. Einecs 266-410-9

    42. Nsc 357088

    43. Nsc 375489

    44. Unii-1f7a44v6ou

    45. Ocufors

    46. Timsaponin-c

    47. Forskolin- Bio-x

    48. (-)-forskolin

    49. Mfcd00082317

    50. Forskolin - 10%

    51. Forskolin - 20%

    52. Forskolin - 40%

    53. Colforsin [inn]

    54. Colforsin [mi]

    55. Colforsin (usan/inn)

    56. Colforsin [usan]

    57. Forskolin [vandf]

    58. Colforsin [mart.]

    59. Forskolin/ Rolipram Mixture

    60. Molmap_000021

    61. 7-beta-acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one

    62. Colforsin [who-dd]

    63. Forskolin [usp-rs]

    64. Schembl4928

    65. 1h-naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-

    66. Cid_47936

    67. Mls001066384

    68. Mls001333255

    69. Mls001333256

    70. Mls002172462

    71. Mls002695942

    72. Forskolin, Analytical Standard

    73. Forskohlii Root Extract (forslean)(20% Forskohlin)

    74. Regid_for_cid_47936

    75. Gtpl5190

    76. Dtxsid8040484

    77. Bcbcmap01_000132

    78. Ohcqjhsobutrhg-kgghgjdlsa-

    79. Bio1_000443

    80. Bio1_000932

    81. Bio1_001421

    82. Hms2235c17

    83. Hms3267i16

    84. Hms3412g19

    85. Hms3676g19

    86. Ex-a5963

    87. Zinc3977779

    88. Tox21_110940

    89. Tox21_302399

    90. Bdbm50010261

    91. Hy-15371g

    92. S2449

    93. Akos024456384

    94. Tox21_110940_1

    95. Am81249

    96. Ccg-268774

    97. Cs-1454

    98. Db02587

    99. Lmpr0104030004

    100. Smp1_000128

    101. Ncgc00024996-03

    102. Ncgc00024996-04

    103. Ncgc00024996-05

    104. Ncgc00024996-06

    105. Ncgc00024996-07

    106. Ncgc00024996-34

    107. Ncgc00177971-03

    108. Ncgc00255526-01

    109. 1h-naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3r-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-

    110. 1h-naphtho(2,1-b)pyran-1-one, Dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-

    111. 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1h-naphtho(2,1-b)pyran-1-one

    112. Ac-33150

    113. As-17443

    114. Bf164487

    115. Hy-15371

    116. Xf165210

    117. Xf165211

    118. Xf165212

    119. Cs-0622781

    120. F0855

    121. M-410

    122. C09076

    123. D03584

    124. Mls-0318096.0001

    125. A850885

    126. Q412747

    127. Sr-01000597378

    128. Forskolin (constituent Of Forskohlii) [dsc]

    129. Forskolin, For Use In Molecular Biology Applications

    130. Q-200888

    131. Sr-01000597378-1

    132. Brd-k09602097-001-04-5

    133. Forskolin, From Coleus Forskohlii, >=98% (hplc), Powder

    134. Forskolin, United States Pharmacopeia (usp) Reference Standard

    135. Coleonol;7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one

    136. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1h-naphtho[2,1-b]pyran-5-yl Acetate

    137. [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-5-yl] Acetate

    138. [3r-(3

    139. [3r-(3?,4a?,5?,6?,6a?,10?,10a?,10b?)]-5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1h-naphtho[2,1-b]pyran-1-one

    140. [3r-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(acetyloxy)-3-e Thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1h-naphtho[2,1-b]pyran-1-one

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 410.5 g/mol
    Molecular Formula C22H34O7
    XLogP31
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count3
    Exact Mass410.23045342 g/mol
    Monoisotopic Mass410.23045342 g/mol
    Topological Polar Surface Area113 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity747
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adjuvants, Immunologic

    Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

    Cardiotonic Agents

    Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)