1. Copper(ii) Chloride
2. Cucl2
3. Cupric Chloride Anhydrous
4. Cupric Chloride Dihydrate
5. Cupric Chloride Eriochalcite (cucl2.2h2o)
6. Cupric Chloride, 64cu-labeled Cpd
7. Cupric Chloride, Dihydrate 2h-labeled Cpd
1. Copper(ii) Chloride
2. Copper Chloride
3. 7447-39-4
4. Cupric Chloride Anhydrous
5. Copper Dichloride
6. Copper Bichloride
7. Cupric Dichloride
8. Copper(2+) Chloride
9. Cucl2
10. Copper Chloride (cucl2)
11. Dichlorocopper
12. Copper(2+)chloride
13. Copper (ii) Chloride
14. Copper(ii) Chloride (1:2)
15. Coclor
16. Copper(ii)chloride
17. Copper(ii) Chloride, Anhydrous
18. Chebi:49553
19. Mfcd00010972
20. Nsc165706
21. Copper Chloride (van)
22. Ccris 6883
23. Hsdb 259
24. Cupric Chloride In Plastic Container
25. Einecs 231-210-2
26. Copper (ii)chloride
27. Copper(ii)-chloride
28. Copper (ii) Cloride
29. Nsc 165706
30. Copper (ii)-chloride
31. Ai3-01658
32. Epitope Id:156811
33. Copper(ii) Chloride, 97%
34. Copper (ii) Chloride, 95%
35. Copper(ii) Chloride, Ultra Dry
36. Unii-p484053j2y
37. Copper(ii) Chloride, Powder, 99%
38. Copper(ii) Chloride, P.a., 97%
39. Copper(ii) Chloride, Lr, >=98%
40. Akos015902778
41. Db09131
42. Bp-13443
43. Nci60_001274
44. Copper (ii) Chloride, Trace Metals Grade
45. Ft-0624119
46. Ec 231-210-2
47. Copper(ii) Chloride, Saj First Grade, >=98.0%
48. Q421781
49. Copper(ii) Chloride, 99.999% Trace Metals Basis
50. Copper(ii) Chloride, Anhydrous, Powder, >=99.995% Trace Metals Basis
51. Copper (ii) Chloride, Ultra Dry, Powder, Ampoule, 99.995% Trace Metals Grade
52. Copper Atomic Spectroscopy Standard Concentrate 1.00 G Cu, 1.00 G/l, For 1l Standard Solution, Analytical Standard
| Molecular Weight | 134.45 g/mol |
|---|---|
| Molecular Formula | Cl2Cu |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 132.867303 g/mol |
| Monoisotopic Mass | 132.867303 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 3 |
| Formal Charge | 0 |
| Complexity | 2.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 2 | |
|---|---|
| Drug Name | Cupric chloride in plastic container |
| Active Ingredient | Cupric chloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | eq 0.4mg copper/ml |
| Market Status | Prescription |
| Company | Hospira |
| 2 of 2 | |
|---|---|
| Drug Name | Cupric chloride in plastic container |
| Active Ingredient | Cupric chloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | eq 0.4mg copper/ml |
| Market Status | Prescription |
| Company | Hospira |
For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).
Copper is an essential nutrient which serves as a co factor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. Copper also helps maintain normal rates of red and white blood cell formation. Providing copper during Total Parenteral Nutrition helps prevent development of the following deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferrin formation, secondary iron deficiency and osteoporosis.
Absorption
Mean copper absorption of 57 percent (range 40 to 70 per cent) following oral administration of 0.4 - 4.5 mg copper (as copper acetate) to four volunteers. An early human study suggested a maximum blood copper concentration was reached some two hours after oral copper chloride administration (1.5 - 12 mg copper)
Route of Elimination
Renal
Volume of Distribution
Copper is distributed to all tissues with the highest concentrations in liver, heart, brain, kidneys and muscle. Intracellular copper is predominantly metallothionein-bound. Reported copper in the lungs, liver, kidney, blood, bile and stomach (33.7, 35.1, 41.4, 13.8, 2.8, and 2988 g/g wet weight respectively)
ICR male mice aged 5 weeks were injected subcutaneously with cadmium chloride, lead acetate, silver nitrate, cupric chloride, a combination of cadmium and silver compounds, or a combination of copper and silver compounds. These injections were carried out 3 times. Twenty four hours after the last injection, they were sacrificed. Cadmium injection significantly stimulated serum ceruloplasmin activity and copper concentration, accompanied by an increase in hepatic copper. Lead injection also slightly increased the serum ceruloplasmin level. In contrast, silver injection markedly decreased both serum ceruloplasmin activity and copper concentration in the serum. Hepatic copper increased slightly after silver injection. The copper injection stimulated copper binding to metallothionein and bile excretion of copper, but not serum ceruloplasmin release. With a copper and silver combination, the effect of silver on serum ceruloplasmin was lost, with a concomitant disappearance of silver from the serum ceruloplasmin fraction in the serum. In the mouse, cadmium and silver, copper antagonistic metals, influence different sites of serum ceruloplasmin metabolism. Excess hepatic copper is partly eliminated by excretion of bile and is partly detoxified by metallothionein induction.
PMID:3606389 Sugawara N, Sugaware C; Arch Toxicol 59 (6): 432-36 (1987)
The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.
The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.
PMID:3008276 Dierickx PJ; Res Commun Chem Pathol Pharmacol 51 (2): 285-88 (1986)
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