1. Acthrel
2. Corticorelin Ovine
1. Corticorelin Ovine
2. 79804-71-0
3. Ovine Crh
4. Ovine Acth Releasing Factor
5. Ovine Crf 41
6. Ovine Corticotropin-releasing Factor
7. Corticotropin-releasing Factor (ovine)
8. Corticotropin-releasing Factor (sheep)
9. Amunine
10. Sheep Corticotropin-releasing Factor (1-41)
11. Corticotropin-releasing Factor (sheep Hypothalamus)
12. Ovine Crf
13. Amunin
14. Ocrh
15. Ovine Corticotropin-releasing Hormone
16. Unii-y124tz0513
17. Corticotropin-releasing Hormone, Ovine
18. Corticorelin Triflutate
19. Dtxsid90229925
20. Sheep Corticotropin-releasing Factor
21. Db09067
22. Y124tz0513
23. S-79804-71-0
Molecular Weight | 4670 g/mol |
---|---|
Molecular Formula | C205H339N59O63S |
XLogP3 | -18.6 |
Hydrogen Bond Donor Count | 66 |
Hydrogen Bond Acceptor Count | 71 |
Rotatable Bond Count | 161 |
Exact Mass | 4669.4924539 g/mol |
Monoisotopic Mass | 4667.4857443 g/mol |
Topological Polar Surface Area | 2010 Ų |
Heavy Atom Count | 328 |
Formal Charge | 0 |
Complexity | 11500 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 45 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
FDA Label
In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a concomitant and prolonged release of the related proopiomelanocortin peptides - and -lipotropins ( -and -LPH) and -endorphin ( -END).
Absorption
Plasma ACTH levels in normal subjects increased 2 minutes after injection of corticorelin doses of 0.3 mcg/kg and reached peak levels after 10-15 minutes. Plasma cortisol levels increased within 10 minutes and reached peak levels at 30 to 60 minutes.
Volume of Distribution
The mean volume of distribution for IR-corticorelin is 6.2 0.5 L
Clearance
95 11 L/m2/day
Plasma half-lives for IR-corticorelin are 11.6 1.5 minutes (mean SE) for the fast component and 73 8 minutes for the slow component.
Corticorelin is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.
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