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    CX717

    DEVELOPMENTS

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    2D Structure
    Also known as: Cx717, 867276-98-0, Cx-717, Unii-7i12yta3qm, 7i12yta3qm, Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone
    Molecular Formula
    C11H11N3O3
    Molecular Weight
    233.22  g/mol
    InChI Key
    KFRQROSRKSVROW-UHFFFAOYSA-N
    FDA UNII
    7I12YTA3QM
    CX-717 is an ampakine compound previously investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone
    2.1.2 InChI
    InChI=1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2
    2.1.3 InChI Key
    KFRQROSRKSVROW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1COCCN1C(=O)C2=CC3=NON=C3C=C2
    2.2 Other Identifiers
    2.2.1 UNII
    7I12YTA3QM
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cx717

    2.3.2 Depositor-Supplied Synonyms

    1. Cx717

    2. 867276-98-0

    3. Cx-717

    4. Unii-7i12yta3qm

    5. 7i12yta3qm

    6. Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone

    7. 2,1,3-benzoxadiazol-5-yl-4-morpholinylmethanone

    8. Cx 717

    9. Morpholine, 4-(2,1,3-benzoxadiazol-5-ylcarbonyl)-

    10. 211735-82-9

    11. Starbld0003244

    12. Cx 717 (pharmaceutical)

    13. Oprea1_513346

    14. Schembl243542

    15. Chembl4791762

    16. Dtxsid301241632

    17. Ex-a6414

    18. Db05047

    19. Bs-47001

    20. Cs-0256234

    2.4 Create Date
    2005-09-07
    3 Chemical and Physical Properties
    Molecular Weight 233.22 g/mol
    Molecular Formula C11H11N3O3
    XLogP30.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count1
    Exact Mass233.08004122 g/mol
    Monoisotopic Mass233.08004122 g/mol
    Topological Polar Surface Area68.5 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity294
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.

    5 Pharmacology and Biochemistry
    5.1 Mechanism of Action

    CX-717 is an ampakine compound. It is a positive allosteric modulator of AMPA receptors. Its action is theorized to be due to the facilitation of transmission at cortical synapses that use glutamate as a neurotransmitter. This in turn may promote plasticity at the synapse, which could translate into better cognitive performance. CX-717 works by allosterically binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. In addition, CX717 could potentially strongly impact the up-regulation of BDNF (brain-derived neurotrophic factor) or NGF (nerve growth factor), two growth factors known to stimulate the formation of new circuitry in the brain associated with forming memory and cognition.