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    Cyproheptadine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 969-33-5, Cyproheptadine hcl, Periactin hydrochloride, Anarexol, Cipractin, Nuran
    Molecular Formula
    C21H22ClN
    Molecular Weight
    323.9  g/mol
    InChI Key
    ZPMVNZLARAEGHB-UHFFFAOYSA-N
    FDA UNII
    0S9323MCT0
    A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H
    2.1.3 InChI Key
    ZPMVNZLARAEGHB-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0S9323MCT0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Antergan

    2. Cyproheptadine

    3. Dihexazin

    4. Periactin

    5. Peritol

    6. Viternum

    2.3.2 Depositor-Supplied Synonyms

    1. 969-33-5

    2. Cyproheptadine Hcl

    3. Periactin Hydrochloride

    4. Anarexol

    5. Cipractin

    6. Nuran

    7. Antegan

    8. Peritol

    9. Periactin Syrup

    10. Component Of Dronactin

    11. Cyproheptadine (hydrochloride)

    12. Cyproheptadine Hydrochloride Anhydrous

    13. Cyproheptadiene Hydrochloride

    14. 41354-29-4

    15. Nsc-169911

    16. Cyproheptadine Hydrochloride Sesquihydrate

    17. Cyproheptadine Hydrochloride (anhydrous)

    18. Cpd000058431

    19. Mls000028462

    20. Chebi:59695

    21. 0s9323mct0

    22. 4-(5h-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine Hydrochloride

    23. Periactine

    24. Nsc-759282

    25. Smr000058431

    26. 4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine Hydrochloride

    27. Cyproheptadine (hydrochloride Sesquihydrate)

    28. 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine Hydrochloride

    29. 1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride

    30. Periactinol (van)

    31. Contrallerg

    32. Kulinet

    33. Kyliver

    34. Sialotin

    35. Vinorex

    36. Istam

    37. Periactinol Hydrochloride

    38. Cyproheptadine Chlorhydrate

    39. 4-(5h-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

    40. 4-(5h-dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine Hydrochloride

    41. Cycloheptadine Hydrochloride

    42. Cyproheptadine Hydrochloride Hydrate

    43. Vufb3511

    44. Sr-01000003077

    45. Einecs 213-535-1

    46. Nsc 169911

    47. C21h21n.hcl

    48. Unii-0s9323mct0

    49. 4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

    50. Ai3-26940

    51. 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

    52. 4-(dibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;hydrochloride

    53. Cycloheptadine Hcl

    54. Prestwick_139

    55. Opera_id_383

    56. Cypoheptadine Hydrochloride

    57. Cyproheptadine-hydrochloride

    58. Piperidine, 4-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, Hydrochloride

    59. Chembl1716

    60. Schembl41842

    61. Mls001077277

    62. Mls001424281

    63. Mls002222173

    64. Regid_for_cid_13770

    65. Cyproptadine Hydrochloride,(s)

    66. Dtxsid5042586

    67. Hy-b0366a

    68. Hms1568e08

    69. Hms3414j05

    70. Hms3678j03

    71. Pharmakon1600-01505973

    72. Bcp34399

    73. Cyproheptadine Hydrochloride (anh.)

    74. Tox21_500246

    75. Anhydrous Cyproheptadine Hydrochloride

    76. Mfcd00012538

    77. Nsc169911

    78. Nsc759282

    79. S2044

    80. Akos015905305

    81. Ccg-101144

    82. Lp00246

    83. Nc00394

    84. Cyproheptadine Hydrochloride (periactin)

    85. Ncgc00093708-01

    86. Ncgc00093708-02

    87. Ncgc00260931-01

    88. Ac-15790

    89. As-14697

    90. Cyproheptadine Hydrochloride [who-dd]

    91. Eu-0100246

    92. Ft-0603147

    93. Sw196450-4

    94. C 6022

    95. C77331

    96. Wln: L C676 Byj Bu- Dt6n Dytj A1 &gh

    97. Sr-01000003077-2

    98. Sr-01000003077-4

    99. Sr-01000003077-9

    100. W-106308

    101. Cyproheptadine Hydrochloride 100 Microg/ml In Methanol

    102. Q27126856

    103. Piperidine,d]cyclohepten-5-ylidene)-1-methyl-, Hydrochloride

    104. 4-(5h-dibenzo [a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

    105. 4-(5h-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidinehydrochloride

    106. 4-(5h-dibenzo[a,d]cyclohepten-5-yli Dine)-methylpiperidine Hydrochloride

    107. 1-methyl-4-(2-tricyclo[9.4.0.0^{3,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride

    108. 1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 323.9 g/mol
    Molecular Formula C21H22ClN
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass323.1440774 g/mol
    Monoisotopic Mass323.1440774 g/mol
    Topological Polar Surface Area3.2 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity423
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCyproheptadine hydrochloride
    PubMed HealthCyproheptadine Hydrochloride (By mouth)
    Drug ClassesRespiratory Agent
    Drug LabelCyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, spa...
    Active IngredientCyproheptadine hydrochloride
    Dosage FormTablet; Syrup
    RouteOral
    Strength4mg; 2mg/5ml
    Market StatusPrescription
    CompanyLyne; Corepharma; Stason Pharms; Ivax Sub Teva Pharms; Pharm Assoc; Par Pharm

    2 of 2  
    Drug NameCyproheptadine hydrochloride
    PubMed HealthCyproheptadine Hydrochloride (By mouth)
    Drug ClassesRespiratory Agent
    Drug LabelCyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, spa...
    Active IngredientCyproheptadine hydrochloride
    Dosage FormTablet; Syrup
    RouteOral
    Strength4mg; 2mg/5ml
    Market StatusPrescription
    CompanyLyne; Corepharma; Stason Pharms; Ivax Sub Teva Pharms; Pharm Assoc; Par Pharm

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Serotonin Antagonists

    Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Gastrointestinal Agents

    Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)