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    Dapiprazole Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PharmaCompass
    $ API Ref.Price (USD/KG) : 28,244Xls

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    2D Structure
    Also known as: 72822-13-0, Dapiprazole hcl, Rev-eyes, Dapiprazole (hydrochloride), Dapiprazolehydrochloride, Glamidolo
    Molecular Formula
    C19H28ClN5
    Molecular Weight
    361.9  g/mol
    InChI Key
    ZIODNPFQZIHCOE-UHFFFAOYSA-N
    FDA UNII
    DS9UJN1I0X
    Dapiprazole Hydrochloride is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris. This prevents smooth muscle contraction and results in vasodilatation. Administered in the eye, dapiprazole hydrochloride produces miosis. In the heart, it may antagonize alpha-1 adrenoreceptors in myocytes causing a mild negative inotropic effect.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H27N5.ClH/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19;/h2-3,6-7H,4-5,8-15H2,1H3;1H
    2.1.3 InChI Key
    ZIODNPFQZIHCOE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    DS9UJN1I0X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)-5,6,7,8,-tetrahydro-1,2,4-triazolo(4,3-a)pyridine Hydrochloride

    2. Dapiprazole

    3. Remydrial

    4. Rev-eyes

    2.3.2 Depositor-Supplied Synonyms

    1. 72822-13-0

    2. Dapiprazole Hcl

    3. Rev-eyes

    4. Dapiprazole (hydrochloride)

    5. Dapiprazolehydrochloride

    6. Glamidolo

    7. Dapiprazole Monohydrochloride

    8. Reversil

    9. Af 2139

    10. Dapiprazole Hydrochloride [usan]

    11. Ds9ujn1i0x

    12. Af-2139

    13. Remydrial

    14. 72822-13-0 (hcl)

    15. Dsstox_cid_28595

    16. Dsstox_rid_82866

    17. Dsstox_gsid_48669

    18. 3-(2-(4-(o-tolyl)piperazin-1-yl)ethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine Hydrochloride

    19. 5,6,7,8-tetrahydro-3-(2-(4-o-tolyl-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine Monohydrochloride

    20. Dapiprazole Hydrochloride (usan)

    21. 1,2,4-triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)-, Monohydrochloride

    22. 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine

    23. Cas-72822-13-0

    24. Unii-ds9ujn1i0x

    25. Rev-eyes (tn)

    26. Reversil Hydrochloride

    27. Glamidolo Hydrochloride

    28. Schembl667604

    29. Chembl1201044

    30. Dtxsid7048669

    31. Hy-a0142a

    32. Hms3746g11

    33. Bcp34410

    34. Tox21_113035

    35. S5281

    36. Akos015966533

    37. Tox21_113035_1

    38. Ac-8851

    39. Ccg-268185

    40. Cs-5720

    41. Dapiprazole Hydrochloride [mart.]

    42. Dapiprazole Hydrochloride [vandf]

    43. Ncgc00262927-01

    44. 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine Hydrochloride

    45. 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine,hydrochloride

    46. 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine;hydrochloride

    47. As-16932

    48. Dapiprazole Hydrochloride [who-dd]

    49. Dapiprazole Monohydrochloride [mi]

    50. Dapiprazole Hydrochloride, >=98% (hplc)

    51. Ft-0665471

    52. D03648

    53. D82527

    54. Dapiprazole Hydrochloride [orange Book]

    55. 822d130

    56. A837632

    57. Q27276579

    58. 3-(2-(4-o-tolylpiperazin-1-yl)ethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine Hydrochloride

    59. 3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine Hydrochloride

    60. 5,6,7,8-tetrahydro-3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)-1,2,4-triazolo(4,3-a)pyridine Monohydrochloride

    2.4 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 361.9 g/mol
    Molecular Formula C19H28ClN5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass361.2033236 g/mol
    Monoisotopic Mass361.2033236 g/mol
    Topological Polar Surface Area37.2 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity395
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic alpha-Antagonists

    Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)