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    Delapril Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 2,302Xls

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    2D Structure
    Also known as: Delapril hcl, 83435-67-0, Adecut, Rev 6000a, Cv 3317, Rev-6000a
    Molecular Formula
    C26H33ClN2O5
    Molecular Weight
    489.0  g/mol
    InChI Key
    FDJCVHVKXFIEPJ-JCNFZFLDSA-N
    FDA UNII
    2SMM3M5ZMH
    Delapril Hydrochloride is the hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid;hydrochloride
    2.1.2 InChI
    InChI=1S/C26H32N2O5.ClH/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22;/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30);1H/t18-,23-;/m0./s1
    2.1.3 InChI Key
    FDJCVHVKXFIEPJ-JCNFZFLDSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2.Cl
    2.1.5 Isomeric SMILES
    CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    2SMM3M5ZMH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cv 3317

    2. Cv-3317

    3. Delapril

    4. Derapril

    5. N-(2,3-dihydro-1h-inden-2-yl)-n-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)alanyl)glycine

    2.3.2 Depositor-Supplied Synonyms

    1. Delapril Hcl

    2. 83435-67-0

    3. Adecut

    4. Rev 6000a

    5. Cv 3317

    6. Rev-6000a

    7. 2smm3m5zmh

    8. Cv-3317

    9. Ethyl (s)-2-(((s)-1-((carboxymethyl)-2-indanylcarbamoyl)ethyl)amino)-4-phenylbutyrate, Monohydrochloride

    10. Delapril (hydrochloride)

    11. 2-[2,3-dihydro-1h-inden-2-yl-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic Acid;hydrochloride

    12. Glycine, N-(2,3-dihydro-1h-inden-2-yl)-n-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-, Monohydrochloride, (s)-

    13. Indalapril

    14. 2-((s)-n-(2,3-dihydro-1h-inden-2-yl)-2-(((s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanamido)acetic Acid Hydrochloride

    15. 2-[(2s)-n-(2,3-dihydro-1h-inden-2-yl)-2-{[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanamido]acetic Acid Hydrochloride

    16. Ccris 1925

    17. Delapril Hydrochloride [usan:jan]

    18. Ncgc00181755-01

    19. Unii-2smm3m5zmh

    20. Cupressin

    21. Delaket

    22. Adecut (tn)

    23. Delapril?hydrochloride

    24. Alindapril Hydrochloride

    25. Dsstox_cid_28523

    26. Dsstox_rid_82795

    27. N-(n-((s)-1-ethoxycarbonyl-3-phenylpropyl)-l-alanyl)-n-(indan-2-yl)glycine Hydrochloride

    28. Dsstox_gsid_48597

    29. Glycine, N-((1s)-1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl-n-(2,3-dihydro-1h-inden-2-yl)-, Monohydrochloride

    30. Schembl120907

    31. Chembl2106126

    32. Dtxsid6048597

    33. Chebi:31462

    34. Delapril Hydrochloride [mi]

    35. Delapril Hydrochloride (jan/usan)

    36. Delapril Hydrochloride [jan]

    37. Tox21_112927

    38. Delapril Hydrochloride [usan]

    39. Mfcd00884619

    40. S5728

    41. Akos015915580

    42. Delapril Hydrochloride [mart.]

    43. Ccg-269602

    44. Delapril Hydrochloride [who-dd]

    45. As-15996

    46. Cas-83435-67-0

    47. Hy-107337

    48. Cs-0028174

    49. D4082

    50. D01667

    51. Q27255552

    52. N-[1-(s)-ethoxycarbonyl-3-phenylpropyl]-(s)-alanyl-n-(2-indanyl)glycine Hydrochloride

    53. N-[1-(s)-ethoxycarbonyl-3-phenylpropyl]-l-alanyl-n-(indan-2-yl)glycine Hydrochloride

    54. 2-((s)-n-(2,3-dihydro-1h-inden-2-yl)-2-((s)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanamido)acetic Acid Hydrochloride

    55. Glycine,n-[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]-l-alanyl-n-(2,3-dihydro-1h-inden-2-yl)-, Monohydrochloride

    56. N-[(s)-1-ethoxycarbonyl-3-phenylpropyl]-l-alanyl-n-(2,3-dihydroinden-2-yl)glycine Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 489.0 g/mol
    Molecular Formula C26H33ClN2O5
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count12
    Exact Mass488.2077999 g/mol
    Monoisotopic Mass488.2077999 g/mol
    Topological Polar Surface Area95.9 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity649
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Angiotensin-Converting Enzyme Inhibitors

    A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)