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    Deracoxib

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

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    2D Structure
    Also known as: 169590-41-4, Deramaxx, 4-(3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1h-pyrazol-1-yl)benzenesulfonamide, Sc 46, Sc 046, Sc 59046
    Molecular Formula
    C17H14F3N3O3S
    Molecular Weight
    397.4  g/mol
    InChI Key
    WAZQAZKAZLXFMK-UHFFFAOYSA-N
    FDA UNII
    VX29JB5XWV
    Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to increase palatability. Deramaxx received FDA approval in August 2002 for "the control of post operative pain and inflammation associated with orthopedic surgery in dogs.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)pyrazol-1-yl]benzenesulfonamide
    2.1.2 InChI
    InChI=1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
    2.1.3 InChI Key
    WAZQAZKAZLXFMK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)F)F
    2.2 Other Identifiers
    2.2.1 UNII
    VX29JB5XWV
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-(3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1h-pyrazol-1-yl)benzenesulfonamide

    2. Deramaxx

    3. Nsc 758935

    2.3.2 Depositor-Supplied Synonyms

    1. 169590-41-4

    2. Deramaxx

    3. 4-(3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1h-pyrazol-1-yl)benzenesulfonamide

    4. Sc 46

    5. Sc 046

    6. Sc 59046

    7. Sc-59046

    8. Deracoxib [usan]

    9. 4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1h-pyrazol-1-yl]benzenesulfonamide

    10. Vx29jb5xwv

    11. Nsc-758935

    12. 4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)pyrazol-1-yl]benzenesulfonamide

    13. Chembl28636

    14. Chebi:73032

    15. Deracoxib (usan)

    16. Ncgc00095312-01

    17. Dsstox_cid_25975

    18. Dsstox_rid_81266

    19. Dsstox_gsid_45975

    20. Deram

    21. Cas-169590-41-4

    22. Deracoxib [usan:inn]

    23. Unii-vx29jb5xwv

    24. Deracoxibum

    25. Deracoxib-[d4]

    26. Deracoxib [inn]

    27. Deracoxib [mi]

    28. Spectrum2_000521

    29. Spectrum3_001677

    30. Spectrum4_001227

    31. Spectrum5_001644

    32. Deracoxib [who-dd]

    33. Schembl24645

    34. Bspbio_003493

    35. Kbiogr_001694

    36. Spbio_000501

    37. Deracoxib [green Book]

    38. Dtxsid4045975

    39. Kbio3_002713

    40. Ex-a887

    41. Hms2093m12

    42. Hms3886o18

    43. Pharmakon1600-01505222

    44. Zinc607803

    45. Amy31402

    46. Bcp04295

    47. Tox21_111503

    48. Bdbm50057583

    49. Ccg-39562

    50. Mfcd09837763

    51. Nsc758935

    52. S5711

    53. Sc-046

    54. Akos016009604

    55. Tox21_111503_1

    56. Bcp9000598

    57. Db11395

    58. Nsc 758935

    59. 4-[5-(3-fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide

    60. Ncgc00095312-02

    61. Ncgc00095312-04

    62. 1-propanol, 2,2-dimethyl-, 1-benzoate

    63. Ac-33031

    64. As-19558

    65. Hy-17509

    66. Bcp0726000080

    67. Sbi-0206729.p001

    68. Ft-0665858

    69. D03689

    70. Ab01563051_01

    71. Sr-05000001985

    72. J-010565

    73. Q5261287

    74. Sr-05000001985-1

    75. Brd-k68558722-001-02-4

    76. 4-[3-difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-pyrazol-1-yl]-benzenesulfonamide

    77. Benzenesulfonamide, 4-(3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1h-pyrazol-1-yl)-

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 397.4 g/mol
    Molecular Formula C17H14F3N3O3S
    XLogP32.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass397.07079698 g/mol
    Monoisotopic Mass397.07079698 g/mol
    Topological Polar Surface Area95.6 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity596
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Cyclooxygenase Inhibitors

    Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)