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    Dexamethasone Sodium Phosphate

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

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    2D Structure
    Also known as: 2392-39-4, Dexamethasone 21-phosphate disodium salt, Dalalone, Dexadreson, Dexamethasone disodium phosphate, Megacort
    Molecular Formula
    C22H28FNa2O8P
    Molecular Weight
    516.4  g/mol
    InChI Key
    PLCQGRYPOISRTQ-FCJDYXGNSA-L
    FDA UNII
    AI9376Y64P
    Dexamethasone Sodium Phosphate is a sodium phosphate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
    2.1.2 InChI
    InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
    2.1.3 InChI Key
    PLCQGRYPOISRTQ-FCJDYXGNSA-L
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
    2.1.5 Isomeric SMILES
    C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    AI9376Y64P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Decadron Phosphate

    2. Dexamethasone 21-phosphate

    3. Dexamethasone 21-phosphate, (6alpha,11beta,16alpha)-isomer

    4. Dexamethasone 21-phosphate, Copper (+2) Salt (2:3), (11beta,16alpha)-isomer

    5. Dexamethasone 21-phosphate, Disodium Salt, (11beta,16alpha)-isomer

    6. Dexamethasone 21-phosphate, Disodium Salt, (6alpha,11beta,16alpha)-isomer

    7. Dexamethasone 21-phosphate, Monosodium Salt, (11beta,16alpha)-isomer

    8. Dexamethasone 21-phosphate, Sodium Salt, (11beta,16alpha)-isomer

    9. Dexamethasone Phosphate

    10. Dexamethasone Phosphate Disodium Salt

    11. Dexamethasonedisodium Phosphate

    12. Solu- Decadron

    13. Spersadex

    14. Spersadox

    2.3.2 Depositor-Supplied Synonyms

    1. 2392-39-4

    2. Dexamethasone 21-phosphate Disodium Salt

    3. Dalalone

    4. Dexadreson

    5. Dexamethasone Disodium Phosphate

    6. Megacort

    7. Soldesam

    8. Dexagro

    9. 55203-24-2

    10. Decadron Phosphate

    11. Dexabene

    12. Orgadrone

    13. Ak-dex

    14. Sodium Dexamethasone Phosphate

    15. Dexamethasone 21-(disodium Phosphate)

    16. Dexamethasone Phosphate Disodium

    17. 2392-39-4 (disodium)

    18. Chebi:4462

    19. Tlc399

    20. Tlc-399

    21. Ai9376y64p

    22. Nsc-756722

    23. Disodium;[2-[(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Phosphate

    24. Spersadox

    25. Decdan

    26. Solu-decadron

    27. Maxidex Ointment

    28. Dsstox_cid_27429

    29. Dsstox_rid_82342

    30. Dsstox_gsid_47429

    31. Hexadrol Injectable

    32. Disodium [2-[(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Phosphate

    33. Colvasone

    34. Dexagel

    35. Onadron

    36. Baldex

    37. Mfcd00079105

    38. Dexaject Sp

    39. Egp 437

    40. Sodium 2-((8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Phosphate

    41. Cas-2392-39-4

    42. Disodium Dexamethasone Phosphate

    43. 21-disodium Phosphate Dexamethasone

    44. Einecs 219-243-0

    45. Dexamethasone-21-phosphate Disodium Salt

    46. Dexamethazone Sodium Phosphate

    47. Unii-ai9376y64p

    48. Ncgc00094644-01

    49. Dalalone (tn)

    50. Mephamesone

    51. Soludecadron

    52. Totocortin

    53. Solupen N

    54. Egp437. Dex-phos

    55. Dexamethasone Sodium Phosphate [usp:ban:jan]

    56. Schembl7778

    57. Decadron Inhalation, Injection, Ophthalmic Solution And Ointment, And Topical Cream

    58. 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen Phosphate) Disodium Salt

    59. Chembl2021430

    60. Dtxsid3047429

    61. Dexamethasone Phosphate Sodium Salt

    62. Bcp16805

    63. Tox21_113181

    64. Tox21_302586

    65. S4028

    66. Akos015896357

    67. Akos015951212

    68. Am84812

    69. Ccg-269820

    70. Ks-1150

    71. Nsc 756722

    72. Ncgc00256783-01

    73. Ac-17992

    74. Dexamethasone Sodium Phosphate (jan/usp)

    75. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11.beta.,16.alpha.)-

    76. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11beta,16alpha)-

    77. Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-(dihydrogen Phosphate) Disodium Salt

    78. Dexamethasone Phosphate (as Sodium)

    79. Dexamethasone Sodium Phosphate [jan]

    80. B1588

    81. Dexamethasone Sodium Phosphate [mart.]

    82. Dexamethasone Sodium Phosphate [vandf]

    83. En300-52795

    84. C08175

    85. D00975

    86. Dexamethasone Sodium Phosphate [usp-rs]

    87. Dexamethasone Sodium Phosphate [who-dd]

    88. Dexamethasone Sodium Phosphate [who-ip]

    89. A816989

    90. A830522

    91. Dexamethasone 21-phosphate Disodium Salt, >=98%

    92. Dexamethasone Sodium Phosphate [green Book]

    93. Dexamethasone Sodium Phosphate [orange Book]

    94. Dexamethasone Sodium Phosphate [usp Impurity]

    95. Dexamethasoni Natrii Phosphas [who-ip Latin]

    96. Dexamethasone 21-phosphate Disodium Salt [mi]

    97. Dexamethasone Sodium Phosphate [usp Monograph]

    98. Q27106391

    99. Neodecadron Component Dexamethasone Sodium Phosphate

    100. Dexamethasone Sodium Phosphate Component Of Neodecadron

    101. Dexamethasone Sodium Phosphate, British Pharmacopoeia (bp) Reference Standard

    102. Dexamethasone Sodium Phosphate, European Pharmacopoeia (ep) Reference Standard

    103. Dexamethasone Sodium Phosphate, United States Pharmacopeia (usp) Reference Standard

    104. 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen Phosphate) Disodium Salt

    105. Dexamethasone Sodium Phosphate For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    106. Dexamethasone Sodium Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

    107. Disodium [2-[(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-3-oxidanylidene-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxidanylidene-ethyl] Phosphate

    108. Disodium 9-fluoro-11beta,17-dihydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl Phosphate

    109. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Sodium Salt (1:2), (11beta,16alpha)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 516.4 g/mol
    Molecular Formula C22H28FNa2O8P
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count3
    Exact Mass516.13012157 g/mol
    Monoisotopic Mass516.13012157 g/mol
    Topological Polar Surface Area147 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity962
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameDexamethasone sodium phosphate
    Drug LabelDexamethasone sodium phosphate is a water-soluble inorganic ester of dexamethasone. It occurs as a white or slightly yellow crystalline powder, is odorless or has a slight odor of alcohol, is exceedingly hygroscopic and is freely soluble in water....
    Active IngredientDexamethasone sodium phosphate
    Dosage FormInjectable; Solution/drops
    RouteOphthalmic, otic; Injection
    Strengtheq 10mg phosphate/ml; eq 0.1% phosphate; eq 4mg phosphate/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa; Hikma Maple; Bausch And Lomb; Alcon Pharms; Luitpold; Agila Speclts

    2 of 2  
    Drug NameDexamethasone sodium phosphate
    Drug LabelDexamethasone sodium phosphate is a water-soluble inorganic ester of dexamethasone. It occurs as a white or slightly yellow crystalline powder, is odorless or has a slight odor of alcohol, is exceedingly hygroscopic and is freely soluble in water....
    Active IngredientDexamethasone sodium phosphate
    Dosage FormInjectable; Solution/drops
    RouteOphthalmic, otic; Injection
    Strengtheq 10mg phosphate/ml; eq 0.1% phosphate; eq 4mg phosphate/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa; Hikma Maple; Bausch And Lomb; Alcon Pharms; Luitpold; Agila Speclts

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]