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    Dexpramipexole

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
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    2D Structure
    Also known as: 104632-28-2, (r)-pramipexole, (r)-n6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine, R-(+)-pramipexole, (6r)-6-n-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Wi638gus96
    Molecular Formula
    C10H17N3S
    Molecular Weight
    211.33  g/mol
    InChI Key
    FASDKYOPVNHBLU-SSDOTTSWSA-N
    FDA UNII
    WI638GUS96
    A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
    2.1.2 InChI
    InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1
    2.1.3 InChI Key
    FASDKYOPVNHBLU-SSDOTTSWSA-N
    2.1.4 Canonical SMILES
    CCCNC1CCC2=C(C1)SC(=N2)N
    2.1.5 Isomeric SMILES
    CCCN[C@@H]1CCC2=C(C1)SC(=N2)N
    2.2 Other Identifiers
    2.2.1 UNII
    WI638GUS96
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2 Amino 6 Propylaminotetrahydrobenzothiazole

    2. 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

    3. 2-amino-6-propylaminotetrahydrobenzothiazole

    4. 4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine

    5. 6,7-tetrahydro-n6-propyl-2,6-benzothiazolediamine Dihydrochloride Monohydrate

    6. Kns 760704

    7. Kns-760704

    8. Kns760704

    9. Mirapex

    10. Pramipexol

    11. Pramipexol Dihydrobromide, (+-)-isomer

    12. Pramipexol Dihydrochloride, (s)-isomer

    13. Pramipexol, (+-)-isomer

    14. Pramipexol, (r)-isomer

    15. Pramipexole

    16. Pramipexole Dihydrochloride

    17. Pramipexole Dihydrochloride Anhydrous

    18. Pramipexole Hydrochloride Monohydrate

    19. Sifrol

    20. Snd 919

    21. Snd 919cl2x

    22. Snd-919

    23. Snd-919cl2x

    24. Snd919cl2x

    2.3.2 Depositor-Supplied Synonyms

    1. 104632-28-2

    2. (r)-pramipexole

    3. (r)-n6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

    4. R-(+)-pramipexole

    5. (6r)-6-n-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

    6. Wi638gus96

    7. Kns-760704

    8. (r)-pramipexole Dihydrochloride

    9. Dexpramipexole Dihydrochloride

    10. Dexpramipexole [usan:inn]

    11. Unii-wi638gus96

    12. Dexpramipexole (usan/inn)

    13. Dexpramipexole [inn]

    14. Schembl74780

    15. Dexpramipexole [usan]

    16. Mls006011813

    17. Chembl249420

    18. Dexpramipexole [who-dd]

    19. Dtxsid50146624

    20. Bcp12512

    21. Zinc3831352

    22. 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-n6-propyl-, (6r)-

    23. Bdbm50568780

    24. Hy-17355b

    25. Stk621530

    26. Akos005555111

    27. Cs-1196

    28. Db15130

    29. Ac-36724

    30. As-56557

    31. Smr004703492

    32. D09886

    33. F19514

    34. Q5268345

    35. (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine

    36. (6r)-n6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

    37. (6r)-n~6~-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

    38. (r)-4,5,6,7-tetrahydro-6-(propylamino)-benzothiazole-2-amine

    39. 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-n6-propyl-, (r)-

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 211.33 g/mol
    Molecular Formula C10H17N3S
    XLogP31.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass211.11431873 g/mol
    Monoisotopic Mass211.11431873 g/mol
    Topological Polar Surface Area79.2 Ų
    Heavy Atom Count14
    Formal Charge0
    Complexity188
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antioxidants

    Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Dopamine Agonists

    Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)