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    Diatrizoate Sodium

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    $ API Ref.Price (USD/KG) : 244Xls

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    2D Structure
    Also known as: Sodium diatrizoate, 737-31-5, Sodium amidotrizoate, Triombrine, Hypaque sodium, Diatrizoic acid sodium salt
    Molecular Formula
    C11H8I3N2NaO4
    Molecular Weight
    635.89  g/mol
    InChI Key
    ZEYOIOAKZLALAP-UHFFFAOYSA-M
    FDA UNII
    V5403H8VG7
    Diatrizoate Sodium is an iodinated radiopaque X-ray contrast medium. Diatrizoate sodium blocks X-rays, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine and allowing visualization of these areas. This contrast agent is used as a diagnostic aid in angiography, urography and radiography. (NCI05)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;3,5-diacetamido-2,4,6-triiodobenzoate
    2.1.2 InChI
    InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1
    2.1.3 InChI Key
    ZEYOIOAKZLALAP-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC(=O)NC1=C(C(=C(C(=C1I)C(=O)[O-])I)NC(=O)C)I.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    V5403H8VG7
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Sodium Diatrizoate

    2. 737-31-5

    3. Sodium Amidotrizoate

    4. Triombrine

    5. Hypaque Sodium

    6. Diatrizoic Acid Sodium Salt

    7. Sodium 3,5-diacetamido-2,4,6-triiodobenzoate

    8. Triombrin

    9. Natrii Amidotrizoas

    10. Vascoray

    11. Conray 35

    12. Hypaque Cysto

    13. Hpaque - Cysto

    14. Amidotrizoato Sodico

    15. Histopaque

    16. Hypaque Sodium 20%

    17. Urovist Sodium

    18. Diatrizoate Sodium Salt

    19. Amidotrizoate De Sodium

    20. Benzoic Acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, Monosodium Salt

    21. Hypaque 50

    22. Md 50

    23. Sodium Diacetyldiaminetriiodobenzoate

    24. Sodium Amidotrizoate (inn)

    25. Urographing 370

    26. Monosodium 3,5-diacetamido-2,4,6-triiodobenzoate

    27. Urografic Acid, Sodium Salt

    28. Diatrizoate Sodium [usp]

    29. Sodium Amidotrizoate [inn]

    30. Ml 216

    31. Win 8308-3

    32. 3,5-diacetamido-2,4,6-triiodobenzoic Acid Sodium Salt

    33. Md-50

    34. Mls000069526

    35. Chebi:53692

    36. V5403h8vg7

    37. Gastrografin

    38. 3,5-diacetylamino-2,4,6-trijodbenzosaeure Natrium

    39. Nsc-61815

    40. Smr000058586

    41. Diatrizoate Sodium (usp)

    42. Sodium;3,5-diacetamido-2,4,6-triiodobenzoate

    43. Diatrizoic Acid Sodium Salt;sodium Amidotrizoate

    44. Benzoic Acid, 3,5-diacetamido-2,4,6-triiodo-, Monosodium Salt

    45. Urovist Sodium 300

    46. Radioselectan

    47. Urovist 300

    48. Natrii Amidotrizoas [inn-latin]

    49. Amidotrizoato Sodico [inn-spanish]

    50. Einecs 212-004-1

    51. Nsc 61815

    52. Amidotrizoate De Sodium [inn-french]

    53. Renografin 76 Injectable (veterinary)

    54. Unii-v5403h8vg7

    55. Hsdb 8078

    56. 3,5-diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt

    57. Urovist Sodium (tn)

    58. 3,5-diacetylamino-2,4,6-trijodbenzosaeure Natrium [german]

    59. Benzoic Acid, 3,5-diacetamido-2,4,6-triiodo-, Sodium Salt

    60. Opera_id_214

    61. Dsstox_cid_2912

    62. Sodium Diatrizoate [ban]

    63. Dsstox_rid_76785

    64. Dsstox_gsid_22912

    65. Schembl37116

    66. Chembl1200581

    67. Dtxsid7022912

    68. Hy-b0926a

    69. Diatrizoate Sodium [vandf]

    70. Diatrizoate Sodium [who-ip]

    71. Tox21_301439

    72. Diatrizoic Acid Sodium Salt Dihydrate

    73. Sodium Amidotrizoate [mart.]

    74. Sodium Amidotrizoate [who-dd]

    75. Sodium Amidotrizoate [who-ip]

    76. Akos024371067

    77. Ccg-270302

    78. Diatrizoate Sodium [green Book]

    79. Diatrizoate Sodium [orange Book]

    80. Diatrizoic Acid Sodium Salt [mi]

    81. Ncgc00255327-01

    82. Cas-737-31-5

    83. Diatrizoate Sodium [usp Monograph]

    84. Sodium Amidotrizoate [ep Impurity]

    85. Natrii Amidotrizoas [who-ip Latin]

    86. Renocal Component Diatrizoate Sodium

    87. Sodium Amidotrizoate [ep Monograph]

    88. Renovist Component Diatrizoate Sodium

    89. Angiovist Component Diatrizoate Sodium

    90. Cs-0013563

    91. Ft-0603095

    92. Diatrizoate Sodium Component Of Renocal

    93. Gastrovist Component Diatrizoate Sodium

    94. Renografin Component Diatrizoate Sodium

    95. Sodium3,5-diacetamido-2,4,6-triiodobenzoate

    96. A17075

    97. D01013

    98. D97593

    99. Diatrizoate Sodium Component Of Renovist

    100. Gastrografin Component Diatrizoate Sodium

    101. Diatrizoate Sodium Component Of Angiovist

    102. Diatrizoate Sodium Component Of Gastrovist

    103. Diatrizoate Sodium Component Of Renografin

    104. Md-gastroview Component Diatrizoate Sodium

    105. Diatrizoate Sodium Component Of Gastrografin

    106. Diatrizoate Sodium Component Of Md-gastroview

    107. Sodium 3,5-bis(acetylamino)-2,4,6-triiodobenzoate

    108. 3,5-diacetamido-2,4,6-tiiodobenzoic Acid Sodium Salt

    109. Q27104811

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 635.89 g/mol
    Molecular Formula C11H8I3N2NaO4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass635.7516 g/mol
    Monoisotopic Mass635.7516 g/mol
    Topological Polar Surface Area98.3 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity396
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    GLOFIL-125 (Sodium Iothalamate I-125 Injection) is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

    4.2 Drug Warning

    Contrast Media

    National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)

    As in the use of any radioactive material, care should be taken to minimize radiation exposure to the patient, consistent with proper patient management, and to insure minimum radiation exposure to occupational workers.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

    Rapid or bolus-like injections should be avoided.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

    Radiopharmaceuticals should be used only by physicians who are qualified by training and experience in the safe use and handling of radionuclides.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

    For more Drug Warnings (Complete) data for Iothalamate (8 total), please visit the HSDB record page.

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    Radioiodine is excreted in human milk during lactation. It is not known whether GLOFIL-125 is excreted in human milk.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

    The renal clearance of sodium iothalamate in man closely approximates that of inulin. The compound is cleared by glomerular filtration without tubular secretion or reabsorption.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

    5.2 Biological Half-Life

    Following infusion administration of I-125 iothalamate, the effective half-life is about 0.07 days.

    US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c