1. Butyl Phthalate
2. Di N Butyl Phthalate
3. Di-n-butyl Phthalate
4. Phthalate, Butyl
5. Phthalate, Di-n-butyl
6. Phthalate, Dibutyl
1. 84-74-2
2. Di-n-butyl Phthalate
3. N-butyl Phthalate
4. Butyl Phthalate
5. Genoplast B
6. Palatinol C
7. Celluflex Dpb
8. Polycizer Dbp
9. Unimoll Db
10. Staflex Dbp
11. Elaol
12. Ergoplast Fdb
13. Witcizer 300
14. Kodaflex Dbp
15. Hexaplas M/b
16. Dibutylphthalate
17. Dibutyl 1,2-benzenedicarboxylate
18. Dibutyl-o-phthalate
19. Dibutyl Benzene-1,2-dicarboxylate
20. Phthalic Acid Dibutyl Ester
21. 1,2-benzenedicarboxylic Acid, Dibutyl Ester
22. Dbp (ester)
23. N-butylphthalate
24. Dibutyl-phthalate
25. Ersoplast Fda
26. Phthalate, Di-n-butyl
27. Uniflex Dbp
28. Hatcol Dbp
29. Dibutyl O-phthalate
30. Rc Plasticizer Dbp
31. Benzene-o-dicarboxylic Acid Di-n-butyl Ester
32. Phthalic Acid, Dibutyl Ester
33. O-benzenedicarboxylic Acid, Dibutyl Ester
34. Rcra Waste Number U069
35. Px 104
36. Ortho-dibutyl Phthalate
37. Phthalic Acid Di-n-butyl Ester
38. Di-n-butylorthophthalate
39. Monocizer Dbp
40. Plasthall Dbp
41. Dibutyl-1,2-benzenedicarboxylate
42. Dibutylphthatlate
43. Vestinol C
44. Hatco Dbp
45. Palatinol Dbp
46. Dibutyl Phthalated
47. Nsc 6370
48. Di-n-butyl Phthalate (dbup)
49. Corflex 440
50. Morflex 240
51. Ruifeng Vp 201
52. Uniplex 150
53. Di-n-butylester Kyseliny Ftalove
54. Chebi:34687
55. Yh-1bd2
56. Nsc-6370
57. 1,2-benzenedicarboxylic Acid, 1,2-dibutyl Ester
58. O-benzenedicarboxylic Acid Dibutyl Ester
59. 1,2-benzenedicarboxylic Acid Dibutyl Ester
60. Chembl272485
61. Dtxsid2021781
62. Benzene-o-dicarboxylic Acid, Di-n-butyl Ester
63. Vp-201
64. 2286e5r2ke
65. Benzenedicarboxylic Acid Dibutyl Ester
66. 1,2-dibutyl Benzene-1,2-dicarboxylate
67. Dsstox_cid_1781
68. Dibutyl Ester Of 1,2-benzenedicarboxylic Acid
69. Dsstox_rid_76324
70. Dsstox_gsid_21781
71. Phthalate, Dibutyl-
72. Caswell No. 292
73. Nutyl Phthalate
74. Dibutyl Phthalate (dbp)
75. Phthalate, Butyl
76. Cas-84-74-2
77. Phthalate, Dibutyl
78. Ccris 2676
79. Hsdb 922
80. Di N Butyl Phthalate
81. Rapidcelltrade Markp
82. Dibutyl Phthalate [nf]
83. Sr-05000001549
84. Einecs 201-557-4
85. Rcra Waste No. U069
86. Epa Pesticide Chemical Code 028001
87. Brn 1914064
88. Di-n-butylester Kyseliny Ftalove [czech]
89. Bufa
90. Unii-2286e5r2ke
91. Ai-3-00283
92. Dibutyll Phthalate
93. Mfcd00009441
94. Benzenedicarboxylic Acid, Dibutyl Ester
95. Spectrum_001975
96. Di(1-butyl) Phthalate
97. Specplus_000628
98. Dibutyl Phthalate, 99%
99. Spectrum3_000874
100. Spectrum4_000714
101. Spectrum5_002068
102. Epitope Id:138714
103. Ec 201-557-4
104. Wln: 4ovr Bvo2
105. Dibutyl Phthalate, >=99%
106. Schembl24051
107. Bspbio_002547
108. Kbiogr_001267
109. Kbioss_002541
110. Spectrum330086
111. Mls002177802
112. Bidd:er0641
113. Divk1c_006724
114. Dibutyl Phthalate [ii]
115. Dibutyl Phthalate [mi]
116. Phthalic Acid, Bis-butyl Ester
117. Gtpl6295
118. Dibutyl Phthalate [hsdb]
119. Dibutyl Phthalate [inci]
120. Kbio1_001668
121. Kbio2_002532
122. Kbio2_005100
123. Kbio2_007668
124. Kbio3_002047
125. Butyl Phthalate [who-dd]
126. Nsc6370
127. Dibutyl Phthalate [mart.]
128. Dibutyl Phthalate, Ar, >=99%
129. Dibutyl Phthalate, Lr, >=98%
130. Dibutyl 1, 2-benzenedicarboxylate
131. Hms2091e09
132. Hms3041e18
133. Pharmakon1600-00330086
134. Dibutyl Phthalate [usp-rs]
135. Bcp24796
136. Hy-y0304
137. Zinc1693431
138. Dibutyl Phthalate, Selectophore(tm)
139. Tox21_201729
140. Tox21_300980
141. Bbl011532
142. Bdbm50371946
143. Nsc755894
144. Stl146650
145. Akos005720807
146. Ccg-230933
147. Db13716
148. Nsc-755894
149. Dibutyl Phthalate [ep Monograph]
150. Ncgc00090769-01
151. Ncgc00090769-02
152. Ncgc00090769-03
153. Ncgc00090769-04
154. Ncgc00090769-05
155. Ncgc00090769-06
156. Ncgc00090769-07
157. Ncgc00090769-08
158. Ncgc00090769-09
159. Ncgc00254882-01
160. Ncgc00259278-01
161. Smr000777923
162. Sbi-0052568.p002
163. Cs-0013564
164. Dibutyl Phthalate, Reagentplus(r), >=99%
165. Ft-0624680
166. P0292
167. S5377
168. Dibutyl Phthalate, Saj Special Grade, >=98.0%
169. Q415612
170. J-503795
171. Sr-05000001549-1
172. Sr-05000001549-3
173. Araldite(r) Resins(modified Epoxy Resins),grade 502
174. Brd-k73477617-001-01-0
175. Brd-k73477617-001-04-4
176. Dibutyl Phthalate, Pestanal(r), Analytical Standard
177. F0001-2134
178. Z277540112
179. Dibutyl Phthalate, Certified Reference Material, Tracecert(r)
180. Phthalic Acid, Bis-butyl Ester 100 Microg/ml In Acetonitrile
181. Phthalic Acid, Bis-butyl Ester 100 Microg/ml In Cychohexane
182. Dibutyl Phthalate, European Pharmacopoeia (ep) Reference Standard
183. Dibutyl Phthalate, United States Pharmacopeia (usp) Reference Standard
184. Dibutyl Phthalate, Pharmaceutical Secondary Standard; Certified Reference Material
| Molecular Weight | 278.34 g/mol |
|---|---|
| Molecular Formula | C16H22O4 |
| XLogP3 | 4.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 10 |
| Exact Mass | 278.15180918 g/mol |
| Monoisotopic Mass | 278.15180918 g/mol |
| Topological Polar Surface Area | 52.6 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 271 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Scrub typhus, a rickettsial disease transmitted by larvae of Leptotrombidium deliense, is of special importance to the Armed Forces personnel, due to the heightened risk to this disease during movement in mite endemic areas during exercise/war. The disease is best prevented by the use of personal protective measures including repellents. Studies were undertaken to determine the relative efficacy of repellents: diethyl toulamide (DEET), dibutyl phthalate (DBP) with an indigenously developed repellent diethyl phenyl acetamide (DEPA) against the larval trombiculid mite. The repellents were tested for persistence on impregnated cloth prior to washing, post washing and ironing by means of a specially fabricated testing kit. Acaricidal efficacy estimation was performed on the treated fabrics and topical application efficacy of repellents on mice was evaluated by a novel animal testing model. DEET and DEPA were found to provide maximum protection (repellence and acaricidal efficacy), could withstand two launderings of the impregnated uniform and also had superior efficacy on topical application (8 h). Ironing was found to significantly reduce the repellence of DEET and DBP. The findings of this study point towards the superiority of DEPA and DEET for impregnation of the uniform cloth as well as for topical application for the prevention of scrub typhus amongst the troops.
PMID:11525158 Tilak R et al; Indian J Med Res 113: 98-102 (2001)
Plasticizers
Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment. (See all compounds classified as Plasticizers.)
P - Antiparasitic products, insecticides and repellents
P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents
P03B - Insecticides and repellents
P03BX - Other insecticides and repellents
P03BX03 - Dibutylphthalate
Dibutyl phthalate administered orally to rats and mice /was/ rapidly absorbed and excreted in urine and feces within 48 hr. Max concentrations in blood /SRP: not DBP itself but a metabolite/ plasma & various organs /occurred/ at 20-30 min; /concentrations were/ greater in liver than fat and spleen.
IOKU ET AL; OSAKA FURITSU KOSHU EISEI KENKYUSHO KENKYU HOKOKU, YAKUJI SHIDO HEN 10: 57 (1976)
Dibutyl phthalate given orally to rats was excreted in urine 30.6-43.5% and in feces 20.0-22.0% in 24 hr. Amounts absorbed by fetuses were approximately /the/ same as by fat tissues.
IOKU ET AL; OSAKA FURITSU KOSHU EISEI KENKYUSHO KENKYU HOKOKU, YAKUJI SHIDO HEN 10: 57 (1976)
Dibutyl phthalate was detected in the bile of rats after oral administration. ... A small part of the dose was absorbed intact through the intestine.
USEPA/ECAO; Phthalate Atlas Report p.IV-2 (1980)
The presence of phthalate esters in the blood of individuals /who had/ ingested food /that/ had been in contact with flexible plastics ... dibutyl phthalate levels detected in the blood were much higher than prior to eating the food in the plastic packaging system ... dibutyl phthalate levels in blood /were/ 0.35 ppm ... compared to an average value of 0.02 ppm prior to the meals.
USEPA/ECAO; Phthalate Atlas Report p.IV-2 (1980)
For more Absorption, Distribution and Excretion (Complete) data for DIBUTYL PHTHALATE (25 total), please visit the HSDB record page.
An individual (male, 36 years, 87 kg) ingested two separate doses of di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) at a rate of approximately 60 ug/kg. Key monoester and oxidized metabolites were identified and quantified in urine continuously collected until 48 hr post-dose. For both DnBP and DiBP, the majority of the dose was excreted in the first 24 hr (92.2 % of DnBP, 90.3 % of DiBP), while only <1 % of the dose was excreted in urine on day 2. In each case, the simple monoesters were the major metabolites (MnBP, 84 %; MiBP, 71 %). For DnBP, approximately 8 % was excreted as various side chain oxidized metabolites. For DiBP, approximately 20 % was excreted mainly as the oxidized side chain metabolite 2OH-MiBP, indicating that the extent of oxidative modification is around 2.5 times higher for DiBP than for DnBP. All DnBP and DiBP metabolites reached peak concentrations between 2 and 4 hr post-exposure, followed by a monotonic decline. For DnBP metabolites, the elimination halftime of MnBP was 2.6 hr; longer elimination halftimes were estimated for the oxidized metabolites (2.9-6.9 hr). For DiBP metabolites, MiBP had the shortest halftime (3.9 hr), and the oxidized metabolites had somewhat longer halftimes (4.1 and 4.2 hr). Together with the simple monoesters, secondary oxidized metabolites are additional and valuable biomarkers of phthalate exposure. This study provides basic human metabolism and toxicokinetic data for two phthalates that have to be considered human reproductive toxicants and that have been shown to be omnipresent in humans.
PMID:22820759 Koch HM et al; Arch Toxicol. 86 (12): 1829-39 (2012)
Main urinary metabolite of (14)C-dibutyl phthalate in the rat, guinea pig and hamster ... the monoester, MBP and its glucuronide. ... small amount of phthalic acid, unchanged DBP and omega and omega-1 oxidation products of MBP.
USEPA/ECAO; Phthalate Atlas Report p.IV-8 (1980)
Metabolites found in rat urine after a single oral dose of (14)C-dibutyl phthalate included: phthalic acid, mono-butyl phthalate, mono-(3-hydroxy-butyl) phthalate, and mono-(4-hydroxy butyl) phthalate.
USEPA/ECAO; Phthalate Atlas Report p.II-11 (1980)
The primary route of MBuP, the major DBP metabolite, elimination in rodents and humans is urinary excretion. The monobutylphthalate glucuronide appears to be the primary metabolite identified in rat urine ... . MBuP is excreted into the bile (about 45%), but only about 5% is eliminated in the feces, indicating that efficient enterohepatic recirculation occurs ... . Biliary metabolites of DBP include monobutylphthalate, monobutylphthalate glucuronide, and oxidized monobutylphthalate glucuronide metabolites ... . Mice are known to excrete higher amounts of glucuronidated phthalate ester metabolites than rats and primates excrete higher levels of glucuronidated phthalate ester metabolites than mice. ...
NTP/CERHR; Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Butyl Phthalate (DBP) p. II-10. Available from, as of April 17, 2008: https://cerhr.niehs.nih.gov/evals/index.html
For more Metabolism/Metabolites (Complete) data for DIBUTYL PHTHALATE (21 total), please visit the HSDB record page.
Whole body (animal studies): virtually all eliminated within 48 hours; [TDR, p. 473]
TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 473
One proposed mechanism of /testicular/ toxicity involves a disturbance in the interaction between germ cells and Sertoli cells. The Sertoli cell-germ cell interaction is generally considered to be required for the differentiation of male germ cells and their progression through the seminiferous epithelium and release as mature spermatozoa. Exposure to di-n-butyl phthalate is associated with both the release of iron from hemoglobin and/or transferrin in the liver and spleen, and the subsequent depletion of iron in the blood and testes. The decreased amount of available iron results in a decrease in succinate dehydrogenase activity in the Sertoli cells, resulting in disturbances in the energy transfer system between Sertoli cells and germ cells; anoxia due to iron depletion and/or disturbances in the energy supply may induce the sloughing of germ cells. Decreases in testicular sorbitol, fructose, and glucose levels have been observed in the testes 3-12 hours post exposure. Two days after exposure, there were significant decreases in sorbitol dehydrogenase and succinate dehydrogenase activities and decreases in testicular iron and zinc levels.
U.S. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for DI-n-BUTYL PHTHALATE p.83 (September 2001) No. 135. Available from, as of April 22, 2008: https://www.atsdr.cdc.gov/toxpro2.html#
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