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2D Structure
Also known as: 15307-81-0, Cataflam, Cgp 45840b, Voltfast, Cambia, Zipsor
Molecular Formula
C14H10Cl2KNO2
Molecular Weight
334.2  g/mol
InChI Key
KXZOIWWTXOCYKR-UHFFFAOYSA-M
FDA UNII
L4D5UA6CB4

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
potassium;2-[2-(2,6-dichloroanilino)phenyl]acetate
2.1.2 InChI
InChI=1S/C14H11Cl2NO2.K/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
2.1.3 InChI Key
KXZOIWWTXOCYKR-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[K+]
2.2 Other Identifiers
2.2.1 UNII
L4D5UA6CB4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dichlofenal

2. Diclofenac

3. Diclofenac Sodium

4. Diclofenac, Sodium

5. Diclonate P

6. Diclophenac

7. Dicrofenac

8. Feloran

9. Gp 45,840

10. Gp-45,840

11. Gp45,840

12. Novapirina

13. Orthofen

14. Orthophen

15. Ortofen

16. Sodium Diclofenac

17. Sr 38

18. Sr-38

19. Sr38

20. Voltaren

21. Voltarol

2.3.2 Depositor-Supplied Synonyms

1. 15307-81-0

2. Cataflam

3. Cgp 45840b

4. Voltfast

5. Cambia

6. Zipsor

7. Diclofenac Potassium [usan:usp]

8. Potassium Diclofenac

9. Potassium;2-[2-(2,6-dichloroanilino)phenyl]acetate

10. Diclofenac (potassium)

11. Cgp-45840b

12. Diclofenac Potassium Salt

13. L4d5ua6cb4

14. Chebi:4508

15. Benzeneacetic Acid, 2-((2,6-dichlorophenyl)amino)-, Monopotassium Salt

16. Potassium 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate

17. Cataflam; Diclofenac Potassium; K-fenak; Potassium Diclofenac; Prosorb

18. Diclofenac Potassium [usan]

19. Unii-l4d5ua6cb4

20. Cataflam (tn)

21. Potassium (o-(2,6-dichloroanilino)phenyl)acetate

22. Cambia (tn)

23. Zipsor (tn)

24. Diclofenac Potassium (usp)

25. Schembl40784

26. Chembl1200804

27. Dtxsid30165212

28. Hms3656d18

29. Diclofenac Potassium [vandf]

30. Diclofenac Potassium [mart.]

31. S3062

32. Diclofenac Potassium [usp-rs]

33. Diclofenac Potassium [who-dd]

34. Akos015889752

35. Akos015994733

36. Diclofenac Potassium Salt [mi]

37. Ccg-267848

38. Ks-5037

39. Ac-18735

40. Diclofenac Potassium [orange Book]

41. Hy-15038

42. Diclofenac Potassium [ep Monograph]

43. Db-043176

44. Diclofenac Potassium [usp Monograph]

45. Cs-0003712

46. Ft-0603076

47. Sw196404-4

48. D00903

49. Q27106401

50. Potassium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate

51. Potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate

52. Potassium (o-((2,6-dichlorophenyl)amino)phenyl)acetate

53. 2-((2,6-dichlorophenyl)amino)benzeneacetic Acid, Monopotassium Salt

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 334.2 g/mol
Molecular Formula C14H10Cl2KNO2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass332.9725654 g/mol
Monoisotopic Mass332.9725654 g/mol
Topological Polar Surface Area52.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity310
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 8  
Drug NameCambia
Drug LabelCAMBIA (Diclofenac Potassium for Oral Solution) is a benzeneacetic acid derivative NSAID. CAMBIA is available as a buffered soluble powder, designed to be mixed with water prior to oral administration. CAMBIA is a white to off-white, buff...
Active IngredientDiclofenac potassium
Dosage FormFor solution
RouteOral
Strength50mg
Market StatusPrescription
CompanyDepomed

2 of 8  
Drug NameCataflam
PubMed HealthDiclofenac
Drug ClassesAnalgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug LabelCataflam (diclofenac potassium immediate-release tablets) is a benzeneacetic acid derivative. Cataflam is available as immediate-release tablets of 50 mg (light brown) for oral administration. The chemical name is 2-[(2,6-dichlorophenyl)amino] benz...
Active IngredientDiclofenac potassium
Dosage FormTablet
RouteOral
Strength50mg
Market StatusPrescription
CompanyNovartis

3 of 8  
Drug NameDiclofenac potassium
Drug LabelDiclofenac potassium tablets USP are a benzeneacetic acid derivative. Diclofenac potassium tablets USP, 50 mg are available as orange, film-coated tablets for oral administration. The chemical name is 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid,...
Active IngredientDiclofenac potassium
Dosage FormTablet
RouteOral
Strength50mg
Market StatusPrescription
CompanyTeva; Apotex; Sandoz; Mylan

4 of 8  
Drug NameZipsor
PubMed HealthDiclofenac
Drug ClassesAnalgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug LabelZipsor (diclofenac potassium) Liquid Filled Capsule is a benzeneacetic acid derivative NSAID. Zipsor is available as liquid-filled capsules of 25 mg for oral administration. The chemical name is 2-[(2,6- dichlorophenyl) amino] benzeneacetic acid mono...
Active IngredientDiclofenac potassium
Dosage FormCapsule
RouteOral
Strength25mg
Market StatusPrescription
CompanyDepomed

5 of 8  
Drug NameCambia
Drug LabelCAMBIA (Diclofenac Potassium for Oral Solution) is a benzeneacetic acid derivative NSAID. CAMBIA is available as a buffered soluble powder, designed to be mixed with water prior to oral administration. CAMBIA is a white to off-white, buff...
Active IngredientDiclofenac potassium
Dosage FormFor solution
RouteOral
Strength50mg
Market StatusPrescription
CompanyDepomed

6 of 8  
Drug NameCataflam
PubMed HealthDiclofenac
Drug ClassesAnalgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug LabelCataflam (diclofenac potassium immediate-release tablets) is a benzeneacetic acid derivative. Cataflam is available as immediate-release tablets of 50 mg (light brown) for oral administration. The chemical name is 2-[(2,6-dichlorophenyl)amino] benz...
Active IngredientDiclofenac potassium
Dosage FormTablet
RouteOral
Strength50mg
Market StatusPrescription
CompanyNovartis

7 of 8  
Drug NameDiclofenac potassium
Drug LabelDiclofenac potassium tablets USP are a benzeneacetic acid derivative. Diclofenac potassium tablets USP, 50 mg are available as orange, film-coated tablets for oral administration. The chemical name is 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid,...
Active IngredientDiclofenac potassium
Dosage FormTablet
RouteOral
Strength50mg
Market StatusPrescription
CompanyTeva; Apotex; Sandoz; Mylan

8 of 8  
Drug NameZipsor
PubMed HealthDiclofenac
Drug ClassesAnalgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug LabelZipsor (diclofenac potassium) Liquid Filled Capsule is a benzeneacetic acid derivative NSAID. Zipsor is available as liquid-filled capsules of 25 mg for oral administration. The chemical name is 2-[(2,6- dichlorophenyl) amino] benzeneacetic acid mono...
Active IngredientDiclofenac potassium
Dosage FormCapsule
RouteOral
Strength25mg
Market StatusPrescription
CompanyDepomed

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cyclooxygenase Inhibitors [MoA]; Decreased Prostaglandin Production [PE]; Nonsteroidal Anti-inflammatory Drug [EPC]; Anti-Inflammatory Agents, Non-Steroidal [CS]