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    Dicyclomine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

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    $ API Ref.Price (USD/KG) : 345Xls

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    2D Structure
    Also known as: 67-92-5, Dicyclomine hcl, Dicycloverine hydrochloride, Bentyl, Merbentyl, Kolantyl hydrochloride
    Molecular Formula
    C19H36ClNO2
    Molecular Weight
    345.9  g/mol
    InChI Key
    GUBNMFJOJGDCEL-UHFFFAOYSA-N
    FDA UNII
    CQ903KQA31
    A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
    2.1.3 InChI Key
    GUBNMFJOJGDCEL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    CQ903KQA31
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bentyl

    2. Bentylol

    3. Di Cyclonex

    4. Di Spaz

    5. Di-cyclonex

    6. Di-spaz

    7. Dibent

    8. Diclomin

    9. Dicyclomine

    10. Dicycloverin

    11. Hydrochloride, Dicyclomine

    12. Lomine

    13. Merbentyl

    14. Or Tyl

    15. Or-tyl

    16. Spascol

    2.3.2 Depositor-Supplied Synonyms

    1. 67-92-5

    2. Dicyclomine Hcl

    3. Dicycloverine Hydrochloride

    4. Bentyl

    5. Merbentyl

    6. Kolantyl Hydrochloride

    7. Procyclomin

    8. Bentomine

    9. Dicyclomine (hydrochloride)

    10. Mamiesan

    11. Sawamin

    12. Atumin

    13. Dyspas

    14. Oxityl-p

    15. Diocyl Hydrochloride

    16. Wyovin Hydrochloride

    17. Bentylol

    18. Wyovin

    19. Dicycloverin Hydrochloride

    20. 67-92-5 (hcl)

    21. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate Hydrochloride

    22. Mls000028426

    23. Mls001074064

    24. Cq903kqa31

    25. 2-(diethylamino)ethyl (bicyclohexyl)-1-carboxylate Hydrochloride

    26. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydrochloride

    27. Nsc-404381

    28. Diethylaminocarbethoxybicyclohexyl Hydrochloride

    29. 2-diethylaminoethyl Bicyclohexyl-1-carboxylate Hydrochloride

    30. Antispas

    31. Benacol

    32. Icramin

    33. Smr000058440

    34. Spasmoject

    35. Stannitol

    36. Ametil

    37. Dibent

    38. (bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

    39. Bis(cyclohexyl)carboxylic Acid Diethylaminoethyl Ester Hydrochloride

    40. Beta-diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate Hydrochloride

    41. Chebi:4515

    42. Bentyl Preservative Free

    43. Sr-01000003056

    44. Einecs 200-671-1

    45. Nsc 404381

    46. Unii-cq903kqa31

    47. Ai3-18105

    48. Dicyclomine Hydrochloride [usp]

    49. Prestwick_891

    50. Bentyl (tn)

    51. Mfcd00079158

    52. Opera_id_272

    53. Beta-diethylaminoethyl-1-cyclohexylhexahydrobenzoate Hydrochloride

    54. Dicyclomine Hydrochloride (preservative-free)

    55. Dicyclomine, Hydrochloride

    56. Beta-diethylaminoethyl-1-cyclohexylcyclohexanecarboxylate Hydrochloride

    57. (1,1'-bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

    58. 1-cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester Hydrochlorid [german]

    59. Cloridrato Dell'estere Beta-dietil Aminoetilico Dell'acido Cicloesil-1-cicloesancarbossilico

    60. Schembl41670

    61. Dicyclominehydrochloride

    62. Spectrum1500240

    63. Chembl1200479

    64. Dtxsid0058778

    65. Regid_for_cid_441344

    66. Hms1568i17

    67. Hms1920e22

    68. Pharmakon1600-01500240

    69. Dicycloverine For System Suitability

    70. Hy-b1339

    71. Tox21_500432

    72. Ccg-39149

    73. Dicyclomine Hydrochloride (jan/usp)

    74. Nsc756727

    75. Dicyclomine Hydrochloride [mi]

    76. (2-(((1,1'-bicyclohexyl)-1-ylcarbonyl)oxy)ethyl)diethylammonium Chloride

    77. 1-cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester Hydrochlorid

    78. Akos015950777

    79. Dicyclomine Hydrochloride [jan]

    80. Lp00432

    81. Nc00504

    82. Nsc-756727

    83. Dicyclomine Hydrochloride [vandf]

    84. Ncgc00093853-01

    85. Ncgc00093853-02

    86. Ncgc00093853-03

    87. Ncgc00093853-04

    88. Ncgc00093853-05

    89. Ncgc00261117-01

    90. Bs-18961

    91. Dicyclomine Hydrochloride [usp-rs]

    92. Dicycloverine Hydrochloride [mart.]

    93. Dicycloverine Hydrochloride [who-dd]

    94. Cs-0013089

    95. Eu-0100432

    96. Ft-0624744

    97. Sw197012-3

    98. D 7909

    99. D00717

    100. Dicyclomine Hydrochloride [orange Book]

    101. Dicyclomine Hydrochloride [usp Monograph]

    102. 067d925

    103. Dicyclomine Hydrochloride, >=99% (tlc), Powder

    104. Dicycloverine Hydrochloride [ep Monograph]

    105. Sr-01000003056-2

    106. Sr-01000003056-7

    107. Q27106404

    108. Diethylaminocarbethoxy-bicyclohexyl Hydrochloride

    109. 2-(diethylamino)ethyl Bi(cyclohexane)-1-carboxylate Hydrochloride

    110. 2-(diethylamino)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate Hydrochloride

    111. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydron;chloride

    112. Dicycloverine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    113. (1,1'-bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

    114. [1,1'-bicyclohexyl]-1-carboxylic Acid 2-(diethylamino) Ethyl Ester, Hydrochloride

    115. 1-cyclohexylhexahydrobenzoic Acid(beta)-diethylaminoethyl Ester Hydrochloride

    116. Dicyclomine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 345.9 g/mol
    Molecular Formula C19H36ClNO2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count8
    Exact Mass345.2434571 g/mol
    Monoisotopic Mass345.2434571 g/mol
    Topological Polar Surface Area29.5 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity326
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameBentyl
    Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcoh...
    Active IngredientDicyclomine hydrochloride
    Dosage FormInjectable; Tablet; Syrup; Capsule
    RouteInjection; Oral
    Strength10mg/5ml; 10mg; 10mg/ml; 20mg
    Market StatusPrescription
    CompanyAptalis Pharma Us; Forest Labs

    2 of 8  
    Drug NameBentyl preservative free
    Active IngredientDicyclomine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength10mg/ml
    Market StatusPrescription
    CompanyForest Labs

    3 of 8  
    Drug NameDicyclomine hydrochloride
    Active IngredientDicyclomine hydrochloride
    Dosage FormTablet; Syrup; Capsule
    RouteOral
    Strength10mg/5ml; 10mg; 20mg
    Market StatusPrescription
    CompanyWatson Labs; Lannett; Mikart; Mylan

    4 of 8  
    Drug NameDicyclomine hydrochloride
    PubMed HealthDicyclomine
    Drug ClassesGastrointestinal Agent
    Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosageforms:Dicyclomine Hydrochloride Capsules, USP for oral use contain 10 mg dicyclomine hydrochloride, USP. Dicyclomine hydroch...
    Active IngredientDicyclomine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength10mg/ml
    Market StatusPrescription
    CompanyEurohlth Intl

    5 of 8  
    Drug NameBentyl
    Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcoh...
    Active IngredientDicyclomine hydrochloride
    Dosage FormInjectable; Tablet; Syrup; Capsule
    RouteInjection; Oral
    Strength10mg/5ml; 10mg; 10mg/ml; 20mg
    Market StatusPrescription
    CompanyAptalis Pharma Us; Forest Labs

    6 of 8  
    Drug NameBentyl preservative free
    Active IngredientDicyclomine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength10mg/ml
    Market StatusPrescription
    CompanyForest Labs

    7 of 8  
    Drug NameDicyclomine hydrochloride
    Active IngredientDicyclomine hydrochloride
    Dosage FormTablet; Syrup; Capsule
    RouteOral
    Strength10mg/5ml; 10mg; 20mg
    Market StatusPrescription
    CompanyWatson Labs; Lannett; Mikart; Mylan

    8 of 8  
    Drug NameDicyclomine hydrochloride
    PubMed HealthDicyclomine
    Drug ClassesGastrointestinal Agent
    Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosageforms:Dicyclomine Hydrochloride Capsules, USP for oral use contain 10 mg dicyclomine hydrochloride, USP. Dicyclomine hydroch...
    Active IngredientDicyclomine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength10mg/ml
    Market StatusPrescription
    CompanyEurohlth Intl

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cholinergic Antagonists [MoA]; Anticholinergic [EPC]