1. 2-mee Cpd
1. 111-77-3
2. Diethylene Glycol Monomethyl Ether
3. Methyl Carbitol
4. Methoxydiglycol
5. Methyl Digol
6. Ethanol, 2-(2-methoxyethoxy)-
7. Dowanol Dm
8. Poly-solv Dm
9. Methyl Dioxitol
10. 3,6-dioxa-1-heptanol
11. Mecb
12. Ektasolve Dm
13. Diethylene Glycol Methyl Ether
14. Diglycol Monomethyl Ether
15. Degme
16. 2-(2-methoxyethoxy)-ethanol
17. Diethyleneglycol Monomethyl Ether
18. Methyl Karbitol
19. Methyl-peg2-alcohol
20. Ethylene Diglycol Monomethyl Ether
21. Nsc 2261
22. Ethanol, 2,2'-oxybis-, Monomethyl Ether
23. 465ddj8g8k
24. .beta.-methoxy-.beta.'-hydroxydiethyl Ether
25. Dtxsid3025049
26. Chebi:44836
27. Nsc-2261
28. Ncgc00163771-03
29. Jeffersol Dm
30. Dowanol 16
31. Caswell No. 338b
32. Methyldiglycol
33. Egme, Di-
34. Diethylene Glycol Monome Methylether
35. Methyl Karbitol [czech]
36. Hsdb 96
37. Pg0
38. Mpeg2-oh
39. Einecs 203-906-6
40. Epa Pesticide Chemical Code 042204
41. Beta-methoxy-beta'-hydroxydiethyl Ether
42. Brn 1697812
43. Methylcarbitol
44. Unii-465ddj8g8k
45. 2-(2-methoxy-ethoxy)ethanol
46. 2-(2-methoxyethoxy) Ethanol
47. Ai3-18364
48. 2-(2-methoxyethoxy)ethan-1-ol
49. Hicotol Car
50. Diethylene Glycol-monomethyl Ether
51. 2-(methoxyethoxy)ethanol
52. Dsstox_cid_5049
53. 2-(methoxyethoxy)-ethanol
54. Ec 203-906-6
55. Dsstox_rid_77640
56. 2-(2-methoxyethoxyl)ethanol
57. Dsstox_gsid_25049
58. Schembl15778
59. 4-01-00-02392 (beilstein Handbook Reference)
60. Methoxydiglycol [inci]
61. Wln: Q2o2o1
62. Diethyleneglycol Monomethylether
63. Glycol Ether Dm Reagent Grade
64. 2-(2'-methoxyethoxy) Ethanol
65. 2-(2-methoxy Ethoxy) Ethanol
66. 2-(2-methoxy-ethoxy)-ethanol
67. Diethylene Glycol Monomethylether
68. Chembl1235250
69. Nsc2261
70. M-peg-oh, Mw 2,000
71. M-peg-oh, Mw 5,000
72. Zinc1577245
73. M-peg-oh, Mw 30,000
74. Tox21_400009
75. Diethylene Glycol Methyl Ether, 99%
76. Mfcd00002871
77. Stl280434
78. Akos009156476
79. Ethanol,2'-oxybis-, Monomethyl Ether
80. Cs-w013578
81. Hy-w012862
82. Ncgc00163771-01
83. Ncgc00163771-02
84. Ncgc00163771-04
85. As-12944
86. Bp-13446
87. Bp-23184
88. Bp-23185
89. Bp-27937
90. Cas-111-77-3
91. Ft-0624900
92. M0537
93. D78002
94. Diethylene Glycol Monomethyl Ether [mi]
95. Diethylene Glycol Monomethyl Ether [hsdb]
96. Poly(oxy-1,2-ethanediyl), A-methyl-w-hydroxy-
97. Q1925579
98. W-109062
99. Diethylene Glycol Monomethyl Ether (stabilized With Bht)
100. Z1251171284
101. Diethylene Glycol Methyl Ether, Reagentplus(r), >=99.0%
102. Diethylene Glycol Methyl Ether, Saj First Grade, >=99.0%
103. Diethylene Glycol Monomethyl Ether, Purum, >=99.0% (gc)
104. Diethylene Glycol Methyl Ether, Vetec(tm) Reagent Grade, 98%
105. 2-(2-methoxyethoxy)ethanol Stabilized With ~100ppm 2,6-di-tert-butyl-4-methylphenol
| Molecular Weight | 120.15 g/mol |
|---|---|
| Molecular Formula | C5H12O3 |
| XLogP3 | -0.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 120.078644241 g/mol |
| Monoisotopic Mass | 120.078644241 g/mol |
| Topological Polar Surface Area | 38.7 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 38.7 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
EXPL : Structure activity studies with nine glycol alkyl ethers were conducted with a cellular leukemia transplant model in male Fischer rats to measure the effects on neoplastic progression in transplant recipients. Chemicals were given ad libitum in the drinking water simultaneously with the transplants and continued throughout the study. In all, 20 million leukemic cells were injected sc into syngeneic rats, which after 60 days resulted in a 10-fold increase in relative spleen weights, a 100-fold increase in white blood cell counts, and a 50% reduction in red blood cell indices and platelet counts. Ethylene glycol monomethyl ether given at a dose of 2.5 mg/mL in the drinking water completely eliminated all clinical, morphological, and histopathological evidence of leukemia, whereas the same dose of ethylene glycol monoethyl ether reduced these responses by about 50%. Seven of the glycol ethers were ineffective as anti-leukemic agents, including ethylene glycol, the monopropyl, monobutyl, and monophenyl ethylene glycol ethers, diethylene glycol, and the monomethyl and monoethyl diethylene glycol ethers.
PMID:2357763 Dieter MP et al; Cancer Chemother Pharmacol 26 (3): 173-80 (1990)
Retrocaval ureter is a very rare condition. In light of the experimental studies, one of the etiologic factors seems to be maternal contact with diethylene glycol monomethyl ether or ethylene glycol monomethyl ether. A case of cardiovascular, skeletal, and retrocaval ureter anomalies caused by possible maternal contact while pregnant with these materials at her work in a textile factory is presented.
PMID:12149723 Karaman MI et al; J Pediatr Surg 37 (8): E23 (2002)
It has been estimated that the single oral dose /of diethylene glycol/ lethal for humans is approximately 1 mL/kg. /Diethylene glycols/
Doull, J., C.D.Klassen, and M.D. Amdur (eds.). Casarett and Doull's Toxicology. 3rd ed., New York: Macmillan Co., Inc., 1986., p. 656
... /It is/ absorbed by skin ... .
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 633
... Material can be absorbed through skin of rabbits in toxic amounts... .
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 634
To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. The appearance of glycol ether in an aqueous receptor phase bathing the underside of the epidermis was quantified by a gas chromatographic technique. A final determination of tritiated water permeability was compared with initial values to establish any irreversible alterations in epidermal barrier function induced by contact with the glycol ethers. 2-methoxyethanol (EM) was most readily absorbed (mean steady rate 2.82 mg/sq cm/hr), and a relatively high absorption rate (1.17 mg/sq cm/hr) was also apparent for 1-methoxypropan-2-ol (PM). There was a trend of reducing absorption rate with increasing molecular weight or reducing volatility for monoethylene glycol ethers (EM, 2.82 mg/sq cm/hr; 2-ethoxyethanol, EE, 0.796 mg/sq cm/hr; 2-butoxyethanol, EB, 0.198 mg/sq cm/hr) and also within the diethylene glycol series: 2-(2-methoxyethoxy) ethanol (DM, 0.206 mg/sq cm/hr); 2-(2-ethoxyethoxy) ethanol (DE, 0.125 mg/sq cm/hr) and 2-(2-butoxyethoxy) ethanol (DB, 0.035 mg/sq cm/hr). The rate of absorption of 2-ethoxyethyl acetate (EEAc) was similar to that of the parent alcohol, EE. Absorption rates of diethylene glycol ethers were slower than their corresponding monoethylene glycol equivalents. Combination of intrinsic toxicity and ability to pass across skin contribute to assessment of hazards of contact with undiluted glycol ethers.
PMID:6499804 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568269 Dugard PH et al; Environ Health Perspect 57: 193-7 (1984)
The toxicity of bis(2-methoxyethyl)ether was studied in rats. Male Sprague-Dawley rats were given 0.051, or 5.1 mmol/kg (14)C labeled bis(2-methoxyethyl)ether orally. The principal urinary metabolites were (2-methoxyethoxy)acetic acid and methoxyacetic acid which accounted for around 70 and 6% of the doses, respectively. Smaller amounts of N-(methoxyacetyl)glycine, diglycolic acid, 2-methoxyethanol, and 2-(2-methoxyethoxy)ethanol were found. Only unchanged bis(2-methoxyethyl)ether was found in the volatile organic fraction of the expired air. Additionally, rats were given up to 20 daily doses of 5.1 mmol/kg 2-(2-methoxyethoxy)ethanol or (2-methoxyethoxy)acetic acid at on days 3 through 21. 2-(2-Methoxyethoxy)ethanol and (2-methoxyethoxy)acetic acid induced no gross or histopathological testicular changes. Bis(2-methoxyethyl)ether metabolism proceeds primarily through an O-demethylation pathway, followed by oxidation to (2-methoxyethoxy)acetic acid. The lack of toxicity of 2-(2-methoxyethoxy)ethanol and (2-methoxyethoxy)acetic acid suggests that the testicular toxicity of bis(2-methoxyethyl)ether may be due to methoxyacetic acid, a minor metabolite.
Cheever KL et al; Toxicol and Appl Pharmacol 94 (1): 150-9 (1988)
...Male Sprague-Dawley rats were given 0.051, or 5.1 mmol/kg (14)C labeled bis(2-methoxyethyl)ether orally. The principal urinary metabolites were (2-methoxyethoxy)acetic acid and methoxyacetic acid which accounted for around 70 and 6% of the doses, respectively. Smaller amounts of N-(methoxyacetyl)glycine, diglycolic acid, 2-methoxyethanol, and 2-(2-methoxyethoxy)ethanol were found. Only unchanged bis(2-methoxyethyl)ether was found in the volatile organic fraction of the expired air. ...Bis(2-methoxyethyl)ether metabolism proceeds primarily through an O-demethylation pathway, followed by oxidation to (2-methoxyethoxy)acetic acid. The lack of toxicity of 2-(2-methoxyethoxy)ethanol and (2-methoxyethoxy)acetic acid suggests that the testicular toxicity of bis(2-methoxyethyl)ether may be due to methoxyacetic acid, a minor metabolite.
Cheever KL et al; Toxicol and Appl Pharmacol 94 (1): 150-9 (1988)
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