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    Dihydroquinine

    ACTIVE PHARMA INGREDIENTS

    DIGITAL CONTENT

    PharmaCompass
    $ API Ref.Price (USD/KG) : 13,510Xls

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    2D Structure
    Also known as: Dihydroquinine, Chembl2079611, (-)-hydroquinine, 10,11-dihydroquinine, (-)-10,11-dihydroquinine, Nsc-41799
    Molecular Formula
    C20H26N2O2
    Molecular Weight
    326.4  g/mol
    InChI Key
    LJOQGZACKSYWCH-WGFDLZGGSA-N
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (R)-(5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
    2.1.2 InChI
    InChI=1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13?,14?,19?,20-/m1/s1
    2.1.3 InChI Key
    LJOQGZACKSYWCH-WGFDLZGGSA-N
    2.1.4 Canonical SMILES
    CCC1CN2CCC1CC2C(C3=C4C=C(C=CC4=NC=C3)OC)O
    2.1.5 Isomeric SMILES
    CCC1CN2CCC1CC2[C@@H](C3=C4C=C(C=CC4=NC=C3)OC)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Dihydroquinidine

    2. Dihydroquinine

    3. Hydroquinidine

    4. Hydroquinidine Dihydrochloride, (1beta,4beta,3s)-(+-)-isomer

    5. Hydroquinidine Dihydrochloride, (3alpha,9s)-(+-)-isomer

    6. Hydroquinidine Hydrochloride

    7. Hydroquinidine Monosulfate

    8. Hydroquinidine Monosulfate, (1beta,3alpha,4beta,8alpha,9r)-isomer

    9. Hydroquinidine Monosulfate, (1beta,3alpha,4beta,9s)-isomer

    10. Hydroquinidine Sulfate

    11. Hydroquinidine Sulfate, (9s)-isomer

    12. Hydroquinidine, (+-)-isomer

    13. Hydroquinidine, (1beta, 3alpha,4beta,8alpha,9r)-isomer

    14. Hydroquinidine, (1beta,3alpha,4beta,9s)-isomer

    15. Hydroquinidine, (1beta,4beta,9s)-(+-)-isomer

    16. Hydroquinidine, (3alpha,9s)-(+-)-isomer

    17. Hydroquinidine, (8alpha,9r)-isomer

    18. Hydroquinidine, (8alpha,9s)-isomer

    19. Hydroquinidine, (9r)-isomer

    20. Hydroquinidine, (9s)-(+-)-isomer

    21. Lcn 834

    22. Lcn-834

    23. Lentoquine

    24. Srcor

    2.2.2 Depositor-Supplied Synonyms

    1. Dihydroquinine

    2. Chembl2079611

    3. (-)-hydroquinine

    4. 10,11-dihydroquinine

    5. (-)-10,11-dihydroquinine

    6. Nsc-41799

    7. 522-66-7

    8. Schembl109602

    9. Bdbm50407154

    10. Cs-w019883

    11. Hy-42034

    12. J3.558.731d

    13. (r)-(5-ethyl-1-azabicyclo[2.2.2]octane-2-yl)(6-methoxy-4-quinolinyl)methanol

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 326.4 g/mol
    Molecular Formula C20H26N2O2
    XLogP33.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass326.199428076 g/mol
    Monoisotopic Mass326.199428076 g/mol
    Topological Polar Surface Area45.6 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity432
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count3
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    4.2 ATC Code

    M - Musculo-skeletal system

    M09 - Other drugs for disorders of the musculo-skeletal system

    M09A - Other drugs for disorders of the musculo-skeletal system

    M09AA - Quinine and derivatives

    M09AA01 - Hydroquinine